Patents by Inventor Masao Kawakita

Masao Kawakita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of detecting colorectal cancer of stages 0 to I
    Patent number: 9134313
    Abstract: A tumor marker comprising diacetylspermine, and a method of evaluating the state of a tumor, comprising reacting an antibody to diacetylspermine with a biological sample to thereby detect diacetylspermine and evaluating the state of the tumor using the obtained detection results as an indicator.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: September 15, 2015
    Assignees: Tokyo Metropolitan Organization For Medical Research, CRC Inc., Tokyo Metropolitan Government, Trans Genic Inc.
    Inventors: Masao Kawakita, Kyoko Hiramatsu, Keiichi Takahashi, Naotaka Hamasaki, Koji Yamaguchi, Tsunehisa Kaku, Koichiro Muta, Munechika Enjoji, Seiji Naito, Jun Hayashi, Shoshu Mitsuyama, Hiroyuki Yamashita, Toru Inoue, Masato Kato
  • High affinity anti-N,N-diacetylspermine monoclonal antibody
    Patent number: 7700741
    Abstract: The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is that the 50% inhibition activity against the immunoreaction by the diacetylspermine in the sample is at least 1,000 times as much as the 50% inhibition activity against the immunoreaction by the N1-acetylspermidine in the sample.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: April 20, 2010
    Assignee: Trans Genic Inc.
    Inventors: Yusei Nagase, Shingo Shinagawa, Masao Kawakita, Kyoko Hiramatsu, Mika Ito, Yosuke Mizukami, Chiemi Minoda
  • HIGH AFFINITY ANTI-N1,N12-DIACETYLSPERMINE MONOCLONAL ANTIBODY
    Publication number: 20100093006
    Abstract: The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is that the 50% inhibition activity against the immunoreaction by the diacetylspermine in the sample is at least 1,000 times as much as the 50% inhibition activity against the immunoreaction by the N1-acetylspermidine in the sample.
    Type: Application
    Filed: October 13, 2009
    Publication date: April 15, 2010
    Inventors: Yusei Nagase, Shingo Shinagawa, Masao Kawakita, Kyoko Hiramatsu, Mika Ito, Yosuke Mizukami, Chiemi Minoda
  • N1, N12-DIACETYLSPERMINE AS TUMOR MARKER
    Publication number: 20090298098
    Abstract: A tumor marker comprising diacetylspermine, and a method of evaluating the state of a tumor, comprising reacting an antibody to diacetylspermine with a biological sample to thereby detect diacetylspermine and evaluating the state of the tumor using the obtained detection results as an indicator.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 3, 2009
    Applicants: TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH, CRC Inc., Tokyo Metropolitan Government, Trans Genic Inc.
    Inventors: Masao KAWAKITA, Kyoko HIRAMATSU, Keiichi TAKAHASHI, Naotaka HAMASAKI, Koji YAMAGUCHI, Tsunehisa KAKU, Koichiro MUTA, Munechika ENJOJI, Seiji NAITO, Jun HAYASHI, Shoshu MITSUYAMA, Hiroyuki YAMASHITA, Toru INOUE, Masato KATO
  • N1,n12-diacetylspermine as tumor marker
    Publication number: 20070161059
    Abstract: A tumor marker comprising diacetylspermine, and a method of evaluating the state of a tumor, comprising reacting an antibody to diacetylspermine with a biological sample to thereby detect diacetylspermine and evaluating the state of the tumor using the obtained detection results as an indicator.
    Type: Application
    Filed: March 11, 2004
    Publication date: July 12, 2007
    Applicant: Trans Genic Inc.
    Inventors: Masao Kawakita, Kyoko Hiramatsu, Keiichi Takahashi, Naotaka Hamasaki, Koji Yamaguchi, Tsunehisa Kaku, Koichiro Muta, Munechika Enjoji, Seiji Naito, Jun Hayashi, Shoshu Mitsuyama, Hiroyuki Yamashita, Toru Inoue, Masato Kato
  • High affinity anti-N¹,N¹²-diacetylspermine monoclonal antibody
    Publication number: 20060166297
    Abstract: The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is that the 50% inhibition activity against the immunoreaction by the diacetylspermine in the sample is at least 1,000 times as much as the 50% inhibition activity against the immunoreaction by the N1-acetylspermidine in the sample.
    Type: Application
    Filed: October 31, 2005
    Publication date: July 27, 2006
    Inventors: Yusei Nagase, Shingo Shinagawa, Masao Kawakita, Kyoko Hiramatsu, Mika Ito, Yosuke Mizukami, Chiemi Minoda