Abstract: A hybridoma producing a monoclonal antibody recognizing the C-terminus of human brain natriuretic peptide (hBNP) was cultivated in a medium or the abdominal cavity of a mouse to recover the monoclonal antibody from the medium or ascites accumulated in the abdominal cavity. An immunoassay for hBNP was established using the monoclonal antibody. The immunoassay for hBNP of the invention is so sensitive that the minimum detection limit is 1 pg/ml and can therefore determine the hBNP level in blood plasma directly, without the extraction of hBNP from blood plasma. It is useful for diagnosing diseases such as hypertension and the like, and states of the heart, kidney, and the like by using the increase/decrease of the hBNP level as an index.

Abstract: There is provided a highly reliable screen input type display device using a touch panel which can facilitate the control of a gap formed between upper and lower substrates and can stabilize the linearity of the resistance value detection of a resistance film, whereby an erroneous detection of coordinated can be eliminated. For this purpose, a tape-like conductive pressure sensitive adhesive member, which is formed by sandwiching a metal foil with conductive pressure sensitive adhesive material, is used at a connection portion between an upper wiring electrode mounted on an upper resistance film formed on an upper substrate and an inter-substrate connection wiring electrode formed on a lower substrate.

Abstract: A hybridoma producing a monoclonal antibody recognizing the C-terminus of human brain natriuretic peptide (hBNP) was cultivated in a medium or the abdominal cavity of a mouse to recover the monoclonal antibody from the medium or ascites accumulated in the abdominal cavity. An immunoassay for hBNP was established using the monoclonal antibody. The immunoassay for hBNP of the invention is so sensitive that the minimum detection limit is 1 pg/ml and can therefore determine the hBNP level in blood plasma directly, without the extraction of hBNP from blood plasma. It is useful for diagnosing diseases such as hypertension and the like, and states of the heart, kidney, and the like by using the increase/decrease of the hBNP level as an index.

Abstract: A touch panel including an upper substrate (4A) consisting of a soft film having an upper resistor film (51) and a lower substrate of a hard plate having a lower resistor film, which are bonded together to face each other. The touch panel provides a detection output representing the position of contact between the upper resistor film (51) and the lower resistor film as two-dimensional coordinate values. Either the upper resistor film (51) or the lower resistor film or both are of a comb shape having a plurality of resistive lines with a common connector (41) at one end.

Abstract: A hybridoma producing a monoclonal antibody recognizing the C-terminus of human brain natriuretic peptide (hBNP) was cultivated in a medium or the abdominal cavity of a mouse to recover the monoclonal antibody from the medium or ascites accumulated in the abdominal cavity. An immunoassay for hBNP was established using the monoclonal antibody. The immunoassay for hBNP of the invention is so sensitive that the minimum detection limit is 1 pg/ml and can therefore determine the hBNP level in blood plasma directly, without the extraction of hBNP from blood plasma. It is useful for diagnosing diseases such as hypertension and the like, and states of the heart, kidney, and the like by using the increase/decrease of the hBNP level as an index.

Abstract: The task of the present invention is to provide a highly reliable screen input type display device using a touch panel which can facilitate the control of a gap formed between upper and lower substrates and can stabilize the linearity of the resistance value detection of a resistance film whereby an erroneous operation of the coordinates detection can be eliminated. To solve such a task, a tape-like conductive pressure sensitive adhesive member which is formed by sandwiching a metal foil with conductive pressure sensitive adhesive material is used at a connection portion between an upper wiring electrode mounted on an upper resistance film formed on an upper substrate and an inter-substrate connection wiring electrode formed on a lower substrate.

Abstract: A method for measuring the concentration of polynucleotide in a sample comprising the steps of: (1) preparing a sample, a Raman scattering active agent capable of bonding to a polynucleotide and a surface-enhanced Raman scattering (SERS) active substrate capable of capturing the agent; (2) mixing the sample, the agent and the substrate to capture the agent which has not been bonded to polynucleotide on the surface of the substrate; (3) irradiating the mixture; and (4) measuring the SERS radiation which is generated by the agent captured on the surface of the substrate.

Abstract: The present invention first provides monoclonal antibodies recognizing membrane phospholipase A.sub.2, namely, monoclonal antibodies PL-49, PL-71, PL-76, and PL-78, hybridomas producing them, methods for producing them, and immunoassays of membrane phospholipase A.sub.2 using them.The immunoassay of PLA.sub.2 M is useful for the diagnosis of articular rheumatism, cancers, and a wide variety of inflammatory states.

Abstract: The radioactive iodine compound of this invention or an intermediate for preparing the compound is represented by the following formula (I): ##STR1## wherein R is H or .sup.125 I. The radioactive compound can readily introduce a radioactive isotope element such as .sup.125 I into an antibody molecule without damaging the activity of the antibody molecule. Therefore, the compound can preferably be used to label an antibody of immunoradiometric assay, and allow a higher degree of measurement sensitivity.

Abstract: The present invention relates to monoclonal antibodies having high affinity to human pancreatic PLA.sub.2, the production thereof, hybridomas producing them and an immunoassay for human pancreatic PLA.sub.2 using them.

Abstract: A substituted aldosterone of the formula: ##STR1## wherein either one of R.sup.1 and R.sup.2 is hydrogen and the other is --S(CH.sub.2).sub.m COR.sup.3 or --OCO(CH.sub.2).sub.n COR.sup.3, provided that when R.sup.1 is hydrogen, R.sup.2 is --S(CH.sub.2).sub.m COR.sup.3 or --OCO(CH.sub.2).sub.n COR.sup.3 and when R.sup.2 is hydrogen, R.sup.1 is --S(CH.sub.2).sub.m COR.sup.3 ; m being an integer from 1 to 3, n being an integer from 1 to 5 and R.sup.3 being hydroxyl, lower alkoxy or a residue of tyramine, tyrosine lower alkyl ester, histamine, histidine, 7-aminoheptanoyltyrosine lower alkyl ester or .beta.-D-galactosidase as optionally iodinated, or its (18-20)-acetal 20,21-ketonide, which is useful as the reagent in determination of aldosterones by radioimmunoassay or enzyme immunoassay.

Abstract: A substituted aldosterone of the formula: ##STR1## wherein either one of R.sup.1 and R.sup.2 is hydrogen and the other is --S(CH.sub.2).sub.m COR.sup.3 or --OCO(CH.sub.2).sub.n COR.sup.3, provided that when R.sup.1 is hydrogen, R.sup.2 is --S(CH.sub.2).sub.m COR.sup.3 or --OCO(CH.sub.2).sub.n COR.sup.3 and when R.sup.2 is hydrogen, R.sup.1 is --S(CH.sub.2).sub.m COR.sup.3 ; m being an integer from 1 to 3, n being an integer from 1 to 5 and R.sup.3 being hydroxyl, lower alkoxy or a residue of tyramine, tyrosine lower alkyl ester, histamine, histidine, 7-aminoheptanoyltyrosine lower alkyl ester or .beta.-D-galactosidase as optionally iodinated, or its (18-20)-acetal 20,21-ketonide, which is useful as the reagent in determination of aldosterones by radioimmunoassay or enzyme immunoassay.

Abstract: In copying apparatus having a magnification ratio varying device, wherein a photosensitive member in motion is exposed to an optical image of an original by slit exposing to form an electrostatic latent image thereon and the original scanning velocity is varied in accordance with the magnification ratio selected, it is necessary to effect registration of the forward end of the image of an original with the leading end of a photosensitive sheet or a transfer-printing sheet. The above-mentioned registration is effected by delivering a copy sheet after lapse of a predetermined period of time following the production of a detection signal by a detector, the above-mentioned predetermined period of time being varied in conformity with the selected one of magnification ratios.

Abstract: The disclosed peptide derivative of the formula:Y--Tyr--Gly--RWherein, Y represents a hydrogen atom or an amino protecting group, Tyr represents a tyrosine residue wherein at least one of the hydrogen atoms on the phenyl ring may be substituted by a radioactive iodine, Gly represents a glycine residue, and R represents a peptide residue corresponding to an amino acid sequence which includes at least positions 7 through 21 of human proinsulin C-peptide proves to be useful for determining C-peptide level in human serum.

Abstract: In copying apparatus having a magnification ratio varying device, wherein a photosensitive member in motion is exposed to an optical image of an original by slit exposing to form an electrostatic latent image thereon and the original scanning velocity is varied in accordance with the magnification ratio selected, it is necessary to effect registration of the forward end of the image of an original with the leading end of a photosensitive sheet or a transfer-printing sheet.The above-mentioned registration is effected by delivering a copy sheet simultaneously as or after lapse of a predetermined time following the production of a detection signal by a detection means, which detecting position is varied in accordance with the magnification ratio selected.

Abstract: A book type document is placed on a glass platen face down and scanned by a reciprocating optical system one or more times to produce one or more copies respectively. A retractable conveyor comprising an endless belt is moved onto the platen to automatically feed a sheet document inserted thereinto onto the platen for scanning. Where only one copy of a sheet document is required, the optical system is maintained stationary and the sheet document is fed by the conveyor over the platen at the proper speed, thus enabling rapid copying of a large number of sheet documents. The magnification is variable through adjustment of the positions of the elements of the optical system when held stationary and the speed of movement of the document by the conveyor. The conveyor feeds a sheet document onto the platen at high speed and the optical system is reciprocated to scan the document a plurality of times where a plurality of copies of the document are required.

Abstract: A multi-mode copying machine capable of effecting copying in accordance with a sheet mode copying system and a book mode copying system is provided with an original feed apparatus having means for guiding conveyor belts to deflect away from an original irradiation position in their travel, the conveyor belts being adapted to transport an original in sheet form. Further, the original feed apparatus has means for transporting an original in sheet form exactly at a predetermined rate in the sheet mode copying system and for transporting the original without deformation or breakage while being fed at a high rate in the book mode copying system.

Abstract: The copying apparatus has a magnification ratio varying device, and a photosensitive member, in motion, is exposed to an optical image of an original, by slit exposing, to form an electrostatic latent image thereon. The scanning velocity of the original is effected in accordance with the selected magnification ratio. Registration of the forward or leading end of the image of an original with the leading end of a photosensitive sheet or a transfer-printing sheet is effected by delivering a copy sheet, such as a photosensitive sheet or a transfer-printing sheet, to the photosensitive member only after the lapse of a predetermined period of time following production of a detection signal by a detection device cooperable with the leading edge of the original. The predetermined period of time is varied in conformity to the selected magnification ratio.

Abstract: In copying apparatus capable of producing a duplicate from an original differing in size from each other, a lens is moved when the size of a duplicate to be made from an original is to be changed. When the lens is moved along its optical axis, no change is caused to occur in the distribution of the volume of light passing through the lens for exposing an image forming surface to an optical image of the original. However, in case the original is set such that one side thereof is located on a reference position, the lens is moved in a direction perpendicular to its optical axis, with the result that a lack of uniformity will arise in the distribution of the volume of light thrown on the image forming surface through the lens.