Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: An odor evaluation device, including: a gas chromatograph including a separation column configured to temporally separate a plurality of components contained in an odoriferous analysis-target gas; a timing detector configured to detect, for each of the plurality of components, a timing at which the component exits from the separation column; a gas collector configured to collect, into a sample bag, a gas containing all or some of the components exiting from the separation column when the analysis-target gas is passed through the separation column; a timing setter configured to allow a setting of a timing at which a component contained in the gas to be collected into the sample bag exits from the separation column; and a gas introducer configured to introduce a dilution gas into a passage connecting the separation column and the sample bag.

Abstract: It is an object of the present invention to provide host cells, which are able to proliferate in a serum free medium, which are able to synthesize and secrete a large amount of protein of interest, and which are able to produce a glycoprotein having a sugar chain structure. The present invention provides an established cell line, which is established from distal tubular epithelial cells derived from a mammal.

Abstract: A cable-stayed suspension bridge having characteristics of a cable stayed bridge and those of a suspension bridge at the same and time and using one-box and two-box girders in combination is disclosed. The bridge grinder of the cable-stayed suspension bridge includes one-box girders that each extend to both sides through the respective one tower and a two-box girder set in a central portion of the center span between towers in the length direction of the bridge girder. The cable-stayed suspension bridge includes cable-stayed structures in which a respective one of the one-box girders is supported by the tower with plural cables and a suspension structure in which the two-box girder is supported by the plural towers with two main cables and plural hanger ropes. The two-box girder has a central ventilation opening in the central portion as viewed in a transverse direction thereof.

Abstract: A folding portable terminal which can be changed into a desired shape depending on applications of functions such as a telephone, a digital camera, and the like. A folding portable terminal (1) comprises a case (10) with a display section (11) and a case (20) with an operating section (21), and the cases are foldably linked through a hinge mechanism. The hinge mechanism comprises a first hinge section (12) formed by providing a first rotation axis at substantially the center of the case (10) that can be rotated about the first rotation axis in the folding or opening direction relative to the case (20); a second hinge section (24) formed by providing a second rotation axis at substantially the upper end part of the case (20) so as to be parallel to the first rotation axis, the case (20) being rotated in the folding or opening direction relative to the case (10); and means (13a) for linking both ends of the first rotation axis and both ends of the second rotation axis.

Abstract: A folding portable terminal which can be changed into a desired shape depending on applications of functions such as a telephone, a digital camera, and the like. A folding portable terminal (1) comprises a case (10) with a display section (11) and a case (20) with an operating section (21), and the cases are foldably linked through a hinge mechanism. The hinge mechanism comprises a first hinge section (12) formed by providing a first rotation axis at substantially the center of the case (10) that can be rotated about the first rotation axis in the folding or opening direction relative to the case (20); a second hinge section (24) formed by providing a second rotation axis at substantially the upper end part of the case (20) so as to be parallel to the first rotation axis, the case (20) being rotated in the folding or opening direction relative to the case (10); and means (13a) for linking both ends of the first rotation axis and both ends of the second rotation axis.

Abstract: A cable-stayed suspension bridge having characteristics of a cable stayed bridge and those of a suspension bridge at the same and time and using one-box and two-box girders in combination is disclosed. The bridge grinder of the cable-stayed suspension bridge includes one-box girders that each extend to both sides through the respective one tower and a two-box girder set in a central portion of the center span between towers in the length direction of the bridge girder. The cable-stayed suspension bridge includes cable-stayed structures in which a respective one of the one-box girders is supported by the tower with plural cables and a suspension structure in which the two-box girder is supported by the plural towers with two main cables and plural hanger ropes. The two-box girder has a central ventilation opening in the central portion as viewed in a transverse direction thereof.

Abstract: In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

Abstract: In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

Abstract: In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

Abstract: In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

Abstract: An object of the present invention is to provide a portable terminal suitable for a videophone using a multicall and a portable wireless equipment which communicate voice and data at the same time, and which is small and thin and has excellent portability, without being affected by a human body, at the time of conversation. Therefore, a radio unit which requires large power for the communication with the base station and hence is difficult to be made small and a user interface unit which is actually operated by a user are separated, and connected by radio communication with small power.

Abstract: A dual-mode cellular telephone system which is capable of suppressing a narrow-band disturbing signal appearing in a mobile station of a dual-mode cellular telephone system adapted for both an analog system and a digital CDMA system. A CDMA signal from a CDMA base station, and a narrow-band signal from an analog system are received through an antenna by a receiver, whereby they are amplified, subjected to frequency conversion, and input to a variable notch filter. A disturbing signal detection circuit supplies the variable notch filter with a control signal for varying its frequency. Namely, the disturbing signal detection circuit detects a case that an output level of the variable notch filter is at a minimum by changing the notch frequency via a series of sweeping control signals. A control signal at which the output level of the variable notch filter is at a minimum is then fed to the variable notch filter, thereby effectively suppressing any intermodulation distortions present in the mobile station.

Abstract: After the resist is removed with an alkaline solution, a noncorrosive rinse solution is applied to the substrate which is composed of (a) a water-soluble monovalent lower alcohol and an organic or inorganic acid, or (b) a water-soluble monovalent lower alcohol, an organic or inorganic acid and water or (c) an organic or inorganic acid. This rinse solution prevents corrosion completely when a resist is removed from Al-Si-Cu wiring :material, which is widely used as the wiring material for high-density integrated circuits.

Abstract: A GPS position measuring system includes at least one mobile station and a base station associated with the mobile station. The mobile station is provided with an antenna for receiving one or more GPS signals from the corresponding GPS satellites, an amplifying and frequency converting circuit for amplifying the received signal and converting the amplified GPS signal into a signal on an IF band, an analog-to-digital converter for converting the signal on the IF band into a digital signal, and a writing unit for writing the digital signal into a memory card in order to transfer the digital signal to the base station.

Abstract: An AFC circuit stabilizes the frequency of an intermediate frequency signal to be applied to a demodulation circuit. A frequency conversion circuit responds to a local oscillation signal generated from a voltage-controlled oscillation circuit to convert the frequency of a digital modulation signal and applies the converted frequency to the demodulation circuit. A carrier reproduction circuit in the demodulation circuit reproduces the carrier of the intermediate frequency signal to output a synchronizing detection signal. The frequency of the reproduced carrier is frequency-divided by a frequency dividing circuit. A frequency division output thereof is counted by a counter for a definite period. Data is outputted from a microprocessor in response to a count output of the counter and the synchronizing detection signal, and the data is then converted into an AFC voltage by a D/A converter. The converted voltage is supplied as a control voltage to the voltage-controlled oscillation circuit.

Abstract: An MSK signal demodulating circuit including a carrier reproducing circuit for reproducing a carrier phase-synchronized with a component of a mark frequency or a space frequency of an MSK signal, a detector for performing synchronous detection of the MSK signal by means of the reproduced carrier, an identification circuit for converting an analog output from this detector into serial digital data, and a serial-parallel conversion circuit for converting the serial digital data into I, Q parallel data.

Abstract: A frame synchronization stabilizer for stabilizing frame synchronization of received data has a generation circuit for generating a reference pattern which is the same as a predetermined frame synchronization pattern contained in data being transmitted. The stabilizer further has a comparison circuit for comparing, bit by bit, a data pattern in a synchronization pattern area of each frame of the received data with the reference pattern from the generation circuit. The comparison circuit outputs a mismatch pulse each time when a mismatch bit is detected by the comparison, and outputs a match pulse each time when it is detected that the data pattern is fully matched with the reference pattern. The number of the mismatch pulses from the comparison circuit is counted by a first counter. The first counter outputs an out-of frame detection signal when a counted value exceeds a particular value and is reset based upon the match pulse from the comparison circuit.

Abstract: An AFC circuit stabilizes the frequency of an intermediate frequency signal to be applied to a demodulation circuit. A frequency conversion circuit responds to a local oscillation signal generated from a voltage-controlled oscillation circuit to convert the frequency of a digital modulation signal and applies the converted frequency to the demodulation circuit. A carrier reproduction circuit in the demodulation circuit reproduces the carrier of the intermediate frequency signal to output a synchronizing detection signal. The frequency of the reproduced carrier is frequency-divided by a frequency dividing circuit. A frequency division output thereof is counted by a counter for a definite period. Data is outputted from a microprocessor in response to a count output of the counter and the synchronizing detection signal, and the data is then converted into an AFC voltage by a D/A converter. The converted voltage is supplied as a control voltage to the voltage-controlled oscillation circuit.

Abstract: A wound dressing is provided herein for systemic administration of a physiologically- or biologically-active agent by controlled release of the agent into such wound. The wound dressing includes a substrate in the form of a fabric or cloth, at least a portion of which is cellulosic, which has been chemically modified to convert hydroxyl groups in the cellulosic portion to ionic-adsorbing sites. An ionic form of a physiologically- or biologically-active agent, namely an antibacterial agent, an antifungal agent, an analgesic agent, a tissue healant agent, a local anesthetic agent, an antibleeding agent, an enzyme or a vasoconstrictor is adsorbed in that substrate. Ionic bonds hold that agent temporarily to the substrate for controlled release therefrom in proportion to the amount of exudate in contact with the substrate. The ionic bonds are formed by adsorbing that agent on that substrate at room temperature.