Patents by Inventor Masao Motoki

Masao Motoki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified protein for gene transfer and process for producing the same
    Patent number: 6013526
    Abstract: The present invention relates to a process for producing a conjugate of a biologically active peptide or protein having at least one glutamine residue with a high-molecular weight substance containing an amino group. The present invention also relates to a composite of this conjugate with a nucleic acid adsorbed thereto for transferring nucleic acids to mammalian cells.
    Type: Grant
    Filed: September 10, 1997
    Date of Patent: January 11, 2000
    Assignees: Ajinomoto Co., Inc., Drug Delivery System Institute, Ltd.
    Inventors: Yoshiyuki Takahara, Naoyuki Yamada, Masao Motoki
  • Modification of peptide and protein
    Patent number: 6010871
    Abstract: A process for modifying a physiologically active peptide or a physiologically active protein which comprises reacting a physiologically active peptide or a physiologically active protein having at least a glutamine residue with a substance having an amino donor in the presence of a transglutaminase originating in a microorganism to thereby form an acid amide bond at the .gamma.-position acid amide group of the glutamine residue with the amino group of the amino donor; and the product of modification obtained thereby.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: January 4, 2000
    Assignees: Ajinomoto Co., Inc., Drug Delivery System Institute, Ltd.
    Inventors: Yoshiyuki Takahara, Naoyuki Yamada, Masao Motoki
  • Transglutaminase originating from Crassostrea gigas
    Patent number: 5736356
    Abstract: The present invention relates to a transglutaminase originating from Crassostrea gigas, a gene coding for the transglutaminase, a plasmid carrying the gene, a microorganism transformed with the plasmid, a method for producing an intended transglutaminase by cultivating the microorganism and a method for gelating a protein using the transglutaminase originating from Crassostrea gigas. When comparing with other transglutaminases, the transglutaminase originating from Crassostrea gigas has novel characteristic properties such that it can be activated by the action of calcium ions and that it is further activated by the addition of sodium chloride and/or potassium chloride and it is of utility value, in particular, as a gelling agent for foods.
    Type: Grant
    Filed: September 28, 1995
    Date of Patent: April 7, 1998
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kohichiro Sano, Yoshiyuki Kumazawa, Hisashi Yasueda, Katsuya Seguro, Masao Motoki
  • Gene encoding transglutaminase derived from fish
    Patent number: 5607849
    Abstract: The present invention relates to a DNA fragment having a gene derived from fish which codes for a polypeptide possessing transglutaminase activity, a recombinant plasmid comprising a fish-derived DNA fragment which codes for a transglutaminase, a transformant into which a recombinant plasmid comprising a fish-derived DNA fragment which codes for a transglutaminase is introduced, and a method for the production of a transglutaminase, comprising culturing a transformant containing a fish-derived DNA fragment which codes for a transglutaminase.
    Type: Grant
    Filed: January 5, 1996
    Date of Patent: March 4, 1997
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hisashi Yasueda, Kazuo Nakanishi, Masao Motoki, Kazuo Nagase, Hiroshi Matsui
  • Gene encoding transglutaminase derived from fish
    Patent number: 5514573
    Abstract: The present invention relates to a DNA fragment having a gene derived from fish which codes for a polypeptide possessing transglutaminase activity, a recombinant plasmid comprising a fish-derived DNA fragment which codes for a transglutaminase, a transformant into which a recombinant plasmid comprising a fish-derived DNA fragment which codes for a transglutaminase is introduced, and a method for the production of a transglutaminase, comprising culturing a transformant containing a fish-derived DNA fragment which codes for a transglutaminase.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: May 7, 1996
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hisashi Yasueda, Kazuo Nakanishi, Masao Motoki, Kazuo Nagase, Hiroshi Matsui
  • Transgultaminase
    Patent number: 5156956
    Abstract: A transglutaminase catalyzing an acyl transfer reaction of a .gamma.-carboxyamide group of a glutamine residue in a peptide or protein chain in the absence of Ca.sup.2+.
    Type: Grant
    Filed: July 1, 1991
    Date of Patent: October 20, 1992
    Assignees: Ajinomoto Co., Inc., Amano Pharmaceutical Co., Ltd.
    Inventors: Masao Motoki, Atsushi Okiyama, Masahiko Nonaka, Haruo Tanaka, Ryosuke Uchio, Akira Matsuura, Hiroyasu Ando, Koichi Umeda