Abstract: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein Y is S or O;R is hydrogen or alkyl having from about 1 to about 4 carbon atoms;R.sup.1 is hydrogen, alkyl having from about 1 to about 4 carbon atoms, alkoxy having from about 1 to about 4 carbon atoms, halogen or trifluoromethyl;R.sup.2 is hydrogen or unsubstituted or substituted alkyl having from about 1 to about 4 carbon atoms; andR.sup.3 is hydrogen, alkyl having from about 1 to about 6 carbon atoms, cycloalkyl having from about 3 to about 6 carbon atoms, alkoxy having from about 1 to about 4 carbon atoms, aryloxy having from about 6 to about 10 carbon atoms, alkylthio having from about 1 to about 4 carbon atoms, hydroxyalkoxy having from about 1 to about 4 carbon atoms, or unsubstituted or substituted phenyl is useful to obtain inhibition of aldose reduction in animals, including humans.

Abstract: A compound of the formula (I): ##STR1## wherein R is hydrogen or unsubstituted or substituted 1-naphthyl. These compounds are useful to obtain inhibition of aldose reductase in animals, including humans.

Abstract: Benzimidazole derivatives of the formula (I): ##STR1## or a pharmaceutically acceptable acid addition salt thereof wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is ##STR2## or --C.tbd.C--Ar wherein Ar is phenyl unsubstituted or substituted by one to three substituents selected from the group consisting of halo, lower alkyl, hydroxy, unsubstituted or substituted lower alkoxy, aralkyloxy wherein the alkyl moiety is a lower alkyl moiety, lower alkenyloxy, lower alkynyloxy, difluoromethoxy, lower alkylamino, methylenedioxy, trifluoromethyl, cyano, lower alkylthio and lower alkylsulfinyl; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 a hydrogen or lower alkyl or R.sup.4 and R.sup.5 together with the carbon atoms to which they are attached form a cyclopropyl ring; and R.sup.3 is hydrogen, lower alkyl, acyl or lower alkylsulphonyl are useful in the treatment of ulcers of the stomach and duodenum in humans and animals.

Abstract: 4-Quinolone derivatives of the present invention are useful for their anti-inflammatory, anti-allergenic, antitussive, expectorant and antithrombotic activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

Abstract: 3-methylflavone derivatives which are useful in the treatment of allergies, asthma and inflammation.

Abstract: 4-Hydroxy-2-quinolone derivatives are useful for their anti-inflammatory, anti-allergenic, antitussive and expectorant activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

Abstract: As new semi-synthetic antibiotic derivative are provided N-methanesulfonic acid derivatives of 3',4'-dideoxykanamycin B which are less toxic than the parent antibiotic and have useful high antibacterial activity. They are produced by interacting 3',4'-dideoxykanamycin B, an aldehyde such as paraformaldehyde and sulfurous acid or an alkali metal sulfite reagent.