Patents by Inventor Masao Tohno

Masao Tohno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same
    Patent number: 5196567
    Abstract: Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R.sup.1 is a lower alkyl group having 1 to 5 carbon atoms and R.sup.2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, or a lactone having the formula: ##STR3## wherein R.sup.3 and R.sup.4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.
    Type: Grant
    Filed: June 9, 1988
    Date of Patent: March 23, 1993
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Katsuhiro Uchida, Shozo Masumoto, Masao Tohno, Mitsuo Mimura, Makoto Okumura
  • Flurbiprofen derivative ophthalmic preparation
    Patent number: 5171566
    Abstract: There is provided an ophthalmic preparation comprising a fat emulsion containing flurbiprofen or its derivative such as ester as an active ingredient.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: December 15, 1992
    Assignee: The Green Cross Corporation
    Inventors: Yutaka Mizushima, Hiroyuki Okamoto, Shigetoshi Sugio, Kazumasa Yokoyama, Tadakazu Suyama, Masao Tohno, Makoto Okumura, Yoshiaki Konishi, Kiyonoshin Ichikawa, Katsuhiro Uchida
  • Biphenylylpropionic acid derivative and pharmaceutical composition containing the same
    Patent number: 4766148
    Abstract: Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R.sup.1 is a lower alkyl group having 1 to 5 carbon atoms and R.sup.2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, or a lactone having the formula: ##STR3## wherein R.sup.3 and R.sup.4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.
    Type: Grant
    Filed: June 7, 1985
    Date of Patent: August 23, 1988
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Katsuhiro Uchida, Shozo Masumoto, Masao Tohno, Mitsuo Mimura, Makoto Okumura
  • Biphenylylpropionic acid derivative and pharmaceutical composition containing the same
    Patent number: 4699925
    Abstract: Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R.sup.1 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms and m is 0 or an integer of 1. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.
    Type: Grant
    Filed: September 12, 1983
    Date of Patent: October 13, 1987
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Katsuhiro Uchida, Shozo Masumoto, Masao Tohno, Mitsuo Mimura, Makoto Okumura, Kiyonoshin Ichikawa, Misako Matsumura
  • Ester of flurbiprofen and emulsion containing the same
    Patent number: 4613505
    Abstract: There is provided a fat emulsion of an ester of flurbiprofen having the formula ##STR1## wherein R is a group of the formula ##STR2## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, R.sub.2 is a C.sub.1 -C.sub.15 alkyl group or a C.sub.2 -C.sub.8 alkenyl group, and m is zero or an integer of 1; or a lactone group of the formula ##STR3## wherein R.sub.3 and R.sub.4 are same as or different from each other and are a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and n is an integer of 1 or 2.The emulsion containing particles of a vegetable oil dissolving the ester can be orally or parenterally administered to human or animal for analgesia, antiphlogosis and antipyresis in various diseases and exhibits a high activity with small amounts in terms of flurbiprofen as compared with flurbiprofen itself.
    Type: Grant
    Filed: June 19, 1984
    Date of Patent: September 23, 1986
    Assignees: The Green Cross Corporation, Kaken Pharmaceutical Co., Ltd.
    Inventors: Yutaka Mizushima, Katsuhiro Uchida, Shozoh Masumoto, Masao Tohno, Yoshinobu Hashimoto, Kazumasa Yokoyama, Hiroyuki Okamoto, Kiichiro Nabeta, Tadakazu Suyama
  • Ester substituted alkyl-2-(2,6-dichloroanilino)phenyl acetates
    Patent number: 4603217
    Abstract: A novel anti-inflammatory drug, which exhibits rapidly a pharmacological activity, maintains the activity for a long time, and is free from a side effect such as a gastrointestinal disorder or a central nervous disturbance is disclosed.The drug comprises a compound of an alkylcarbonyloxyalkylester or alkenylcarbonyloxyalkylester derivative of indolylacetic acid or anilinophenylacetic acid.The compound is prepared by an esterification reaction.
    Type: Grant
    Filed: July 25, 1984
    Date of Patent: July 29, 1986
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Katsuhiro Uchida, Mitsuo Mimura, Shozo Masumoto, Makoto Okumura, Masao Tohno, Misako Matsumura