Patents by Inventor Masao Tsuda

Masao Tsuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020168337
    Abstract: According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically active substance which is not an endothelin antagonist, and a biodegradable polymer. The sustained-release preparation of the first embodiment is highly efficient in incorporating the water-soluble physiologically active substance and suppresses the initial burst of the water-soluble physiologically active substance. The sustained-release preparation of the present invention is capable of releasing the water-soluble physiologically active substance while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble physiologically active substance in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity.
    Type: Application
    Filed: May 2, 2002
    Publication date: November 14, 2002
    Applicant: TAKADA CHEMICAL INDUSTRIES LTD.
    Inventors: Yasutaka Igari, Yutaka Yamagata, Satoshi Iinuma, Hiroaki Okada, Hitoshi Ikeda, Masao Tsuda, Kazumichi Yamamoto, Mitsuhiro Wakimasu
  • Publication number: 20020058622
    Abstract: According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically active substance which is not an endothelin antagonist, and a biodegradable polymer. The sustained-release preparation of the first embodiment is highly efficient in incorporating the water-soluble physiologically active substance and suppresses the initial burst of the water-soluble physiologically active substance. The sustained-release preparation of the present invention is capable of releasing the water-soluble physiologically active substance while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble physiologically active substance in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity.
    Type: Application
    Filed: November 6, 2001
    Publication date: May 16, 2002
    Inventors: Yasutaka Igari, Yutaka Yamagata, Satoshi Iinuma, Hiroaki Okada, Hitoshi Ikeda, Masao Tsuda, Kazumichi Yamamoto, Mitsuhiro Wakimasu
  • Patent number: 5486472
    Abstract: Disclosed are a monoclonal antibody having affinity for PACAP, a partial peptide thereof, a precursor thereof or VIP; a hybridoma cell which produces the above monoclonal antibody; and an immunoassay for assaying PACAP by a competitive method or a sandwich method using the above antibody, whereby PACAP can be specifically detected with high sensitivity.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: January 23, 1996
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Nobuhiro Suzuki, Chieko Kitada, Masao Tsuda
  • Patent number: 5071841
    Abstract: The present invention provides a sulfur-containing heterocyclic compound of the formula (I) ##STR1## wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon group which may be substituted; B is a carboxyl group which may be esterified or amidated; X is --CH(OH)-- or --CO--; k is 0 or 1; and k' is 0, 1 or 2 or a pharmaceutically acceptable salt thereof.Also, it provides a process for producing the compound (I) or a salt thereof and a pharmaceutical preparation for use in the treatment of osteoporosis comprising the compound (I) or salt thereof.The compounds (I) and salts thereof show excellent bone resorption inhibitory activity.
    Type: Grant
    Filed: December 28, 1989
    Date of Patent: December 10, 1991
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Takashi Sohda, Masao Tsuda, Iwao Yamazaki
  • Patent number: 5036081
    Abstract: Alpha-glucosidase inhibitor is provided as a promoter of calcium absorption in mammals. The examples of the inhibitor are shown by the formula; ##STR1## wherein A stands for a C.sub.1 -C.sub.10 acyclic hydrocarbon group which may be substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or phenyl group which itself may be further substituted, a C.sub.5 -C.sub.6 cyclic hydrocarbon group which may be substituted by hydroxyl, hydroxymethyl, methyl or amino group, or a sugar residue.There is also provided a calcium preparation which contains an .alpha.-glucosidase inhibitor and a calcium source.
    Type: Grant
    Filed: August 22, 1989
    Date of Patent: July 30, 1991
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Takao Matsuo, Hiroyuki Odaka, Tsuyoshi Suzuki, Masao Tsuda
  • Patent number: 5015289
    Abstract: A manufacturing method for a metal body by means of injection molding that comprises the steps of mixing and kneading a metal powder with short fibers such as metallic fibers, carbon fibers and an organic binder, injection-molding the kneaded mixture to form a green body, removing the organic binder from the green body, and sintering the brown body. The short fibers are added in an amount ranging from about 0.1 to 20 wt. % against 100 wt. % of the metal powder and have a melting point of at least 350.degree. C., and at the time of sintering the fibers not less than 30 vol. % become fused and then integrated with the metal. The short fibers act as a reinforcement, strengthening the brown body as well as preventing deformation and cracking of the green body during debinding.
    Type: Grant
    Filed: August 10, 1990
    Date of Patent: May 14, 1991
    Assignee: King Invest Co., Ltd.
    Inventors: Takuo Toda, Masao Tsuda
  • Patent number: 4644012
    Abstract: A compound of the formula ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 and R.sup.3 are independently hydrogen or lower alkyl and Y is carboxyl or a group convertible to carboxyl is effective for prevention or treatment of osteoporosis.
    Type: Grant
    Filed: December 20, 1984
    Date of Patent: February 17, 1987
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masao Tsuda, Yoichi Sawa, Iwao Yamazaki
  • Patent number: 3946989
    Abstract: A slow descender includes a rope pulley and a braking apparatus which restricts the rotation speed of the rope pulley. The braking apparatus includes a mechanical braking device containing a centrifugal brake which has centrifugal weights, a V-shaped lining part cooperating with the weights, and a speed multiplying gearing device connecting the rope pulley and the centrifugal friction brake. The slow descender further includes an oil hydraulic braking device of the vane pump type or of the inscribed gear pump type.
    Type: Grant
    Filed: December 17, 1974
    Date of Patent: March 30, 1976
    Inventor: Masao Tsuda