Abstract: An object is to provide a signal peptide that can secrete a heterologous polypeptide with high efficiency outside the bacterial cell in a bacterium of the genus Bifidobacterium, an expression cassette that can secrete a heterologous polypeptide with high efficiency outside the bacterial cell, a heterologous polypeptide expression vector, a bacterium of the genus Bifidobacterium capable of secreting a heterologous polypeptide. Means for attaining the object is a bacterium of the genus Bifidobacterium transformed by a vector having an expression cassette sequentially comprising a promoter DNA functioning in a bacterium of the genus Bifidobacterium, a DNA encoding the secretory signal peptide, a DNA encoding a scFv antibody having an antitumor activity, and a terminator DNA functioning in the bacterium of the genus Bifidobacterium; and capable of secreting the scFv antibody with high efficiency outside the bacterial cell.

Abstract: An object is to provide a signal peptide that can secrete a heterogeneous polypeptide with high efficiency outside the bacterial cell in a bacterium of the genus Bifidobacterium, an expression cassette that can secrete a heterogeneous polypeptide with high efficiency outside the bacterial cell, a heterogeneous polypeptide expression vector, a bacterium of the genus Bifidobacterium capable of secreting a heterogeneous polypeptide. Means for attaining the object is a bacterium of the genus Bifidobacterium transformed by a vector having an expression cassette sequentially comprising a promoter DNA functioning in a bacterium of the genus Bifidobacterium, a DNA encoding the secretory signal peptide, a DNA encoding a scFv antibody having an antitumor activity, and a terminator DNA functioning in the bacterium of the genus Bifidobacterium; and capable of secreting the scFv antibody with high efficiency outside the bacterial cell.

Abstract: A tone source system for a superior electronic musical instrument suitable for an LSI application in which the wave data can be provided in a time division multiplex form, or the envelope data can be provided in a time division multiplex form in a synchronous relationship with it, and the wave data to which the envelopes are attached can be provided in a time division multiplex form through multiplication of the data.

Abstract: A multiple wave generator for an electronic musical instrument which has a wave data memory storing plural data samples of a wave shape, a wave address register storing wave address data partially designating sampled data in the wave data memory, a difference address register storing difference address data which specifies incremental address amount, a wave address calculator adding the wave address data to the difference address data and writing into the wave address register, the summed address data being separated into wave memory address data and partial address data, and a wave calculator. The wave memory address data, which are part of the wave address data, are applied to the wave data memory for reading out one data sample, and the one data sample and the partial address data are applied to the wave calculator for calculating interpolated wave sample data corresponding to the wave memory address and the partial address.

Abstract: A tone source system for a superior electronic musical instrument suitable for an LSI application in which the wave data can be provided in a time division multiplex form, or the envelope data can be provided in a time division multiplex form in a synchronous relationship with it, and the wave data to which the envelopes are attached can be provided in a time division multiplex form through multiplication of the data.

Abstract: An automatic accompaniment system for use with an electronic musical instrument of a type having keyboard arrangements, which is capable of automatically sounding chords and basses in accordance with a predetermined rhythm of a selected music, the basses of which are each formed by some of tones forming each chord in the case where the right and left hands of a player are used to play the melody and an accompaniment, respectively. To this end, the system includes a counting circuit composed of a binary counter and a decoder, a high frequency pulse generator, a plurality of logical gating elements and a rhythm pulse generator.