Abstract: Provided are a wireless communication apparatus and a reference signal generating method, wherein inter-cell interference is reduced inside and outside a CoMP set. A CoMP mode setting unit (101) sets whether the terminal (100) thereof is a CoMP terminal or a Non-CoMP terminal. When the terminal (100) is set as a Non-CoMP terminal, the hopping pattern calculating unit (104) calculates a ZC sequence number to be used as the transmission timing, from among all the ZC sequence numbers that can be used within the system. When the terminal (100) is set as a CoMP terminal, the hopping pattern calculating unit (104) calculates a ZC sequence number to be used as the transmission timing, by hopping the ZC sequence numbers to be used within the CoMP set. A ZC sequence generating unit (105) generates a ZC sequence to be used as an SRS, using the calculated ZC sequence number.

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

Abstract: The present invention relates to a vector encoding a wildtype or truncated form of erythropoietin receptor (EpoR) to promote T cell survival and proliferation. Specifically, it exemplifies a bicistronic vector that expresses a truncated EpoR with an anti-CD19-41 BB-003? chimeric antigen receptor (CAR) that has a greater ex vivo expansion than CAR-T cells and demonstrates a significantly higher anti-leukemic activity in vivo. It also describes the method of producing cells expressing said vector and the use of these cells to kill CD19+ tumour cells.

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

Abstract: A wire material for an elastic member includes: inner circumferential-side reinforced fibers that are wound in a spiral form; outer circumferential-side reinforced fibers that are provided on an outer circumference of the inner circumferential-side reinforced fibers; and thermosetting resin that is provided in at least a part of the inner circumferential-side reinforced fibers and the outer circumferential-side reinforced fibers and firmly fixes the reinforced fibers with each other. An angle formed by a winding direction of the inner circumferential-side reinforced fibers and a center axis of the winding is 70° to 110°. A winding direction of the outer circumferential-side reinforced fibers with respect to a center axis of the winding is along a direction of a tensile load applied to the wire material for the elastic member in accordance with a load applying torsional stress to the wire material for the elastic member as an externally applied load.

Abstract: The coil spring according to the present invention is a coil spring that is formed by spirally winding a wire rod and that includes a core that is elastically deformable and a reinforced fiber layer including reinforcing fibers wound around an outer circumference of the core and a thermoset resin that firmly adheres the reinforcing fibers to one another, wherein, in at least a part of a surface layer of the reinforced fiber layer, a content percentage of the reinforcing fibers on an inner circumferential side of the coil spring is larger than a content percentage of the reinforcing fibers on an outer circumferential side of the coil spring.

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

Abstract: A wire adapted to an elastic member includes: a core that is made of metal or alloy and is elastically deformable; and an FRP layer configured to cover an outer surface of the core, and including fibers wound around the core, and thermosetting resin provided at least partially to the fibers and fixing the fibers to each other. A winding direction in which the fibers are wound around the core is along a direction of a tensile load out of the tensile load and a compressive load applied to the wire adapted to an elastic member based on a load applied from outside.

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

Abstract: A coil spring includes: a core that is elastically deformable; and a reinforced fiber layer including reinforced fibers wound around an outer circumference of the core, and a thermoset resin that firmly adheres the reinforced fibers to one another. In at least a part of a surface layer of the reinforced fiber layer, a content percentage of the reinforced fibers on an inner circumferential side of the coil spring is larger than a content percentage of the reinforced fibers on an outer circumferential side of the coil spring.

Abstract: A wire material for an elastic member includes: inner circumferential-side reinforced fibers that are wound in a spiral form; outer circumferential-side reinforced fibers that are provided on an outer circumference of the inner circumferential-side reinforced fibers; and thermosetting resin that is provided in at least a part of the inner circumferential-side reinforced fibers and the outer circumferential-side reinforced fibers and firmly fixes the reinforced fibers with each other. An angle formed by a winding direction of the inner circumferential-side reinforced fibers and a center axis of the winding is 70° to 110°. A winding direction of the outer circumferential-side reinforced fibers with respect to a center axis of the winding is along a direction of a tensile load applied to the wire material for the elastic member in accordance with a load applying torsional stress to the wire material for the elastic member as an externally applied load.

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

Abstract: An electrical connector with the function of instantaneous breaking of a current in response to detection of a leak. The connector comprises: a current supply cord for connecting a load to a source; a pair of plug blades connected electrically with the current supply cord and projected out of a connector body; a sensor mounted in the connector body for detecting a current leak; a breaker device for breaking the connection between the plug blades and the current supply cord in response to a detection by the leak detection sensor.