Abstract: Multispecific antigen-binding molecule capable of binding to multiple different antigens, but do not non-specifically crosslink two or more immune cells such as T cells are provided. Methods for producing or enriching a preferred structural form of such multispecific antibody protein, and method for eliminating disulfide heterogeneity of such multispecific antibody proteins are provided. In addition, conformation-specific antibodies that specifically recognize the preferred form of multispecific antibody proteins, and use of the conformation-specific antibodies are provided.

Abstract: The present disclosure provides antigen binding molecules that show binding activity towards Claudin-6 (CLDN6), methods for producing the antigen binding molecules, use of the antigen-binding molecules and immunoconjugates comprising the same in treating and/or preventing cancers, use of the antigen binding molecules in detecting the presence of CLDN6 in biological samples, and use of the antigen binding molecules in diagnosis of various cancers.

Abstract: One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

Abstract: One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

Abstract: The invention provides anti-complement component antibodies such as anti-C1s antibodies and anti-C1r antibodies, and methods of using the same. The invention also provides pharmaceutical formulations comprising the antibodies, and methods of treating an individual having a complement-mediated disease or disorder comprising administering the antibody to the individual. The binding specificity and C1q displacement function of the anti-C1s antibodies and anti-C1r antibodies are evaluated. Time dependent complement neutralization function and binding to native and truncated C1s or C1r proteins are also shown for the antibodies.

Abstract: The invention provides anti-C1s antibodies and methods of using the same. The affinities of the antibodies to C1s depend on pH and other conditions. The invention also provides pharmaceutical formulations comprising the antibodies, and methods of treating an individual having a complement-mediated disease or disorder comprising administering the antibody to the individual. In addition, the binding affinity of the antibody at high and low pH was measured, and mice PK study was conducted on the antibodies, and pharmacokinetics parameters of the antibodies were evaluated in this application.

Abstract: One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

Abstract: One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

Abstract: One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

Abstract: One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

Abstract: One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

Abstract: An information terminal includes a vibrator, a detector, and a communication controller. The vibrator is configured to generate vibration by using magnetism. The detector is configured to detect the vibration. The communication controller is configured to control a data transmission using the vibration of the vibrator, and a data reception using the detector.

Abstract: A monitoring apparatus includes an imaging unit that takes an image of a monitoring area, an intrusion detection sensor that detects intrusion into the monitoring area, and a display unit that displays a range that can be detected by the intrusion detection sensor overlaid on an image of the monitoring area taken by the imaging unit. The range that can be detected by the intrusion detection sensor in the monitoring area is less than or equal to an imaging range of the monitoring area that can be imaged by the imaging unit.

Abstract: A processing device is provided with a disk loading port and a cassette or cartridge loading port both formed in a substantially common top face or surface of the device so that a CD ROM as well as a cartridge ROM may be loaded from the top. A main circuit board, in which a CPU, data processors and other circuits are assembled, is positioned so as to substantially underlie both the disk and cartridge loading ports and generally arranged in a plane parallel to the common top face. The disk operating unit is formed of two portions, one having a lower surface on which the cartridge unit may be detachably mounted, and the other having an elevated portion in which the disk loading port as well as a disk driving mechanism is installed.

Abstract: A processing device is provided with a disk coating port and a cassette or cartridge port both formed on a common top face or surface of the device sot hat a CD ROM as well as a cartridge ROM may be loaded from the top. A main circuit board, in which a CPU, data processors and other circuits are assembled, is positioned so as to underlie both the disk and cartridge loading ports and generally arranged in a plane parallel to the common top face. The disk operating unit is formed of two portions, one having a lower surface on which the cartridge unit may be detachably mounted, and the other having an elevated portion in which the disk loading port as well as a disk driving mechanism is installed.

Abstract: This invention provides a method of regenerating photographic data by combining a few external devices to a conventional video gaming device which is presently popular. In this method, photographic data stored in an optical disk are read out through a CD-ROM driver connected to the interface which is connectable with external memorizing devices and regenerated, in conformity with a system-controlling program and a CD-ROM controlling program each stored in a cassette ROM connected to the interface which is connectable with external memorizing devices, and a display data-preparing program enlarging said photographic data, and a utility program performing dealing and controlling of the referring, zooming and panning operations of said photographic data each stored in said cassette ROM or in another external memorizing device.

Abstract: A search operation control apparatus in an optical disc reader searches a desired position on an optical disc which is controllably rotated at a constant linear velocity and has its information pits arranged in a segmental spiral, in response to a search command which includes information of the desired position. The apparatus has an optical pickup, an optical-pickup moving controller, and an optical-disc driving controller. The optical-pickup moving controller controllably moves the optical pickup from a current position to a desired position at high speed when it receives a search command. The optical-disc driving controller controllably drives the optical disc during an acceleration/deceleration control timing, and a free-run or constant-run time. During the high-speed translation of the optical pickup, spindle servocontrol to the optical disc is not executed, but the acceleration/deceleration control process and the free-run or constant-run control process are executed.

Abstract: A seeking operation control apparatus in an optical disc reader reads track information stored in an optical disc with an optical pickup which is movable in the radial direction in order to seek a desired track. It includes a calculator for calculating track values, a jump driver, a jump controller, and a reading controller. The calculator calculates the number of tracks in the distance between the track onto which the optical pickup is positioned and a desired track based upon track information obtained by the optical pickup. The jump driver induces the optical pickup to jump one or more predetermined tracks. The jump controller controls the jump driver whereby it performs the track jump operation repeatedly as required to make the optical pickup jump the track value calculated by the calculator. The reading controller directs the optical pickup to read track information after the jump control operation is completed.