Abstract: A method for manufacturing a grain-oriented electrical steel sheet includes: heating a steel slab having a prescribed chemical composition to lower than 1250° C. and subjecting the steel slab to hot rolling to obtain a hot-rolled steel sheet; performing hot-band annealing on the hot-rolled steel sheet; pickling the hot-rolled steel sheet which has been subjected to the hot-band annealing; subjecting the hot-rolled steel sheet which has been subjected to the pickling to cold rolling to obtain a cold-rolled steel sheet having a final sheet thickness d of 0.15 to 0.23 mm; performing a decarburization nitriding treatment including decarburization annealing and nitriding on the cold-rolled steel sheet; performing final annealing on the cold-rolled steel sheet which has been subjected to the decarburization nitriding treatment; and then applying a coating liquid for insulation coating formation to the cold-rolled steel sheet which has been subjected to the final annealing and baking the cold-rolled steel sheet.

Abstract: Grain-oriented electrical steel sheet excellent in magnetic properties and excellent in adhesion of a primary coating to the steel sheet is provided. The grain-oriented electrical steel sheet is provided with a base steel sheet having a chemical composition containing C: 0.005% or less, Si: 2.5 to 4.5%, Mn: 0.050 to 1.000%, a total of S and Se: 0.005% or less, sol. Al: 0.005% or less, and N: 0.005% or less and having a balance of Fe and impurities and a primary coating having Mg2 SiO4 as a main constituent formed on a surface of the base steel sheet. A peak position of Al emission intensity obtained when conducting elemental analysis by glow discharge spectrometry from a surface of the primary coating in a thickness direction is present in a range of 2.0 to 12.0 ?m from a surface of the primary coating to the thickness direction. A sum of perimeters of the Al oxides at the peak position of Al emission intensity is 0.20 to 1.00 ?m/?m2, and a number density of Al oxides is 0.02 to 0.20/?m2.

Abstract: Provided is a grain-oriented electrical steel sheet including a base steel sheet, an intermediate layer which is disposed in contact with the base steel sheet and mainly includes silicon oxide, and an insulation coating which is disposed in contact with the intermediate layer and mainly includes phosphate and colloidal silica, in which the base steel sheet contains predetermined chemical composition, BN having an average particle size of 50 to 300 nm is present, when an emission intensity of B is measured using glow discharge emission analysis, predetermined conditions are satisfied, and a ratio of a major axis to a minor axis of BN is 1.5 or less.

Abstract: The present invention relates to a test support method which is a means for predicting whether or not pathological complete response (pCR) will be attained when a preoperative chemotherapy with an anticancer drug is performed, the method using a sample (breast cancer tissue section) collected from a breast cancer patient to be subjected to the preoperative chemotherapy. The test support method includes: [1] the step of acquiring a fluorescence image of a breast cancer tissue section, which fluorescence image shows bright spots of fluorescent nanoparticles labeling one or more kinds of breast cancer-related proteins; [2] the step of acquiring at least one index relating to the expression level(s) of the breast cancer-related protein(s) on the basis of the bright spots of the fluorescence image; and [3] the step of acquiring information for predicting pCR by performing an analysis using the above-described at least one index.

Abstract: A light-emitting colorant-containing particle contains an organic resin and a light-emitting colorant. A content of the light-emitting colorant is in a range of 10 to 80 mol % based on a total amount of a monomer forming the organic resin and the light-emitting colorant. The particle has an average particle diameter in a range of 1 to 100 nm.

Abstract: An object of the present invention is to provide a medium which is capable of inhibiting precipitation and/or aggregation of fluorescent dye-containing resin particles and enables to use the fluorescent dye-containing resin particles for staining after a long-term storage without having to perform complicated operations. The present invention provides a medium for storing fluorescent dye-containing resin particles, wherein, in a particle-containing liquid obtained by adding fluorescent dye-containing resin particles to the medium, the rate of change in the backscatter intensity (transmitted light) at the center of the height of the particle-containing liquid left to stand for 24 hours after the addition is not less than ?1% based on the particle-containing liquid immediately after the addition.

Abstract: Information useful for diagnosis or treatment is acquired by quantitatively evaluating the expression levels of each of a plurality of mutually different domains in the same protein in a human tissue slice, by providing: a staining process of using a plurality of staining reagents having mutually different colorings to stain the plurality of different domains in the same protein; a quantifying step of quantifying the expression levels of each of the plurality of domains; and a calculating step of calculating the ratios between the expression levels of the plurality of domains.

Abstract: A resin fine particle includes a polyester resin; and a basic dye, in which an volume average particle diameter of the resin fine particle is 0.05 ?m or more and 1 ?m or less, and a ratio of a concentration of the basic dye in a center of gravity portion of the resin fine particle to a concentration of the basic dye in a surface layer portion having a depth of 10 nm or less from a surface of the resin fine particle is 0.8 or more.

Abstract: A resin particle includes a binder resin; a fluorescent colorant A; and a colorant B other than the fluorescent colorant A, in which the resin particle includes a region RA in which a content of the fluorescent colorant A is larger than a content of the colorant B and a region RB in which a content of the colorant B is larger than a content of the fluorescent colorant A.

Abstract: A resin particle includes a fluorescent colorant and a color pigment. A hue angle of the resin particle and a hue angle of the fluorescent colorant are different from each other. When a fluorescence peak wavelength in a spectral reflectance of the fluorescent colorant is represented by A (nm), an integrated value of a spectral reflectance (%) of the color pigment in a wavelength range of from A?30 (nm) to A+30 (nm) is 2,500 or more.

Abstract: A resin particle includes a fluorescent colorant and a binder resin. The fluorescent colorant is bound to the binder resin by a chemical bond.

Abstract: A grain-oriented electrical steel sheet according to one embodiment of the present invention includes a steel sheet and an insulation coating, in which the insulation coating contains a first metal phosphate, which is a metal phosphate of one or two more metals selected from Al, Fe, Mg, Mn, Ni, and Zn; a second metal phosphate, which is a metal phosphate of one or two more metals selected from Co, Mo, V, W, and Zr; and colloidal silica, the insulation coating does not contain chromate, and an elution amount of phosphoric acid of the insulation coating as determined by boiling the grain-oriented electrical steel sheet in a boiled pure water for 10 minutes, then measuring an elution amount of phosphoric acid into the pure water, and dividing the amount of phosphoric acid by the area of the insulation coating of the boiled grain-oriented electrical steel sheet is 30 mg/m2 or less.

Abstract: For fluorescent nanoparticles having a zeta potential of ?10 mV to ?60 mV at pH 7.0 or a zeta potential of 0 mV to ?10 mV in a buffer of pH 6.0 to 8.0, an appropriate electrical repulsive force can be generated between biomolecules that are generally negatively charged and the fluorescent nanoparticles. As a result, non-specific binding between the fluorescent nanoparticles and the biomolecules is suppressed and the fluorescent nanoparticles are specifically bound to a biomolecule to be stained through interaction stronger than the electrical repulsive force, so that the visibility of the specific biomolecule to be stained can be improved. Further, since an appropriate electrical repulsive force is also generated between the fluorescent nanoparticles themselves, aggregation of the fluorescent nanoparticles can be inhibited and the dispersibility in a staining solution can thereby be maintained.

Abstract: A multilayer ceramic capacitor satisfies a relationship A>B, where B represents a coverage rate of a first organic layer disposed on a first base electrode layer located on a first end surface, A represents a coverage rate of the first organic layer disposed on the first base electrode layer located on a first main surface or a second main surface, and A represents a coverage rate of the first organic layer located on the first main surface or the second main surface. A second end surface also has a similar configuration.

Abstract: A robot includes a robot main body that includes a base and a robot arm connected to the base, a motor that is provided inside the robot main body and drives the robot arm, a control board that is provided inside the robot main body, a power supply board that supplies electric power to the control board, and a drive board that drives the motor based on a command from the control board, and in which the robot main body includes a suction hole from which a pipe to which a suction device for sucking gas inside the robot main body is connected is detachable.

Abstract: The present invention provides a method of obtaining information for the diagnosis or treatment, mainly of cancer or an immune system-related disease, the method including the step of quantifying the expression level of a cancer-associated protein or a nucleic acid in a tumor cell; and/or the step of quantifying the expression level of a protein or a nucleic acid in an immune cell, using a specimen derived from tumor tissue of a human or a non-human.

Abstract: A grain oriented electrical steel sheet includes: a base steel sheet; a lower layer which is arranged in contact with the base steel sheet; and an insulation coating which is arranged in contact with the lower layer and which includes a phosphate and a colloidal silica as main components. The base steel sheet includes the predetermined chemical composition and includes a B compound whose major axis length is 1 to 20 ?m and whose number density is 1×10 to 1×106 pieces/mm3. The lower layer is a glass film which includes a forsterite as main component or an intermediate layer includes a silicon oxide as main component.

Abstract: A non-oriented electrical steel sheet includes a silicon steel sheet and an insulation coating. When t is a thickness of the silicon steel sheet and when PDR is defined as (PDR=(maximum?minimum)/minimum×100) which indicates a ratio concerned with maximum and minimum of number densities of AlN precipitates in three areas which are 1/10t area, ?t area, and ½t area from a surface of the silicon steel sheet along a thickness direction, the PDR is 50% or less.

Abstract: Disclosed herein is a method including: acquiring one or more pieces of information including information about expression status of a specific biomarker in a lesion collected from a human by using a laboratory animal transplanted with the lesion; and using the information to estimate therapeutic efficacy through analysis

Abstract: An object of the present invention is to provide a method for accurately assessing effectiveness of a medicine that specifically recognizes a target molecule. The present invention can assess therapeutic effects of a medicine by an assessment method including step (P) of obtaining information on the target molecule, and further including at least one step selected from step (A) for obtaining information on a target-related molecule, step (B) for measuring blood concentration of the medicine in a subject, and step (C) of measuring a proportion of cells reached by the medicine (excluding, however, step (A) alone, and step (B) alone).