Abstract: An acid solution preparation device is an acid solution preparation device for preparing an acid solution used for pickling of a steel plate, the device including a sealed tank for storing the acid solution, a gas supply part for supplying an oxygen-containing gas from outside of the sealed tank to the sealed tank, and a purge part for discharging a gas in the sealed tank to the outside.

Abstract: Disclosed is an artificial leather base material including: a non-woven fabric that is an entangle body of fibers (A) and fibers (B); and an elastic polymer applied inside the non-woven fabric, wherein the fibers (A) are crimped fibers that are formed from two types of resins with intrinsic viscosities different from each other, and that are filaments of 0.6 dtex or more, and the fibers (B) are ultrafine fibers of less than 0.6 dtex.

Abstract: A method for pickling a steel plate having a first steel plate portion and a second steel plate portion which is connected to a tail end of the first steel plate portion and which requires a longer time for pickling than the first steel plate portion when pickled under the same condition includes: a step of pickling the steel plate by immersing the steel plate in an acid solution in at least one pickling tank while conveying the steel plate; a step of circulating the acid solution, through a circulation line connected to any of the at least one pickling tank, between the pickling tank and an oxidizing device disposed in the circulation line; a step of oxidizing Fe2+ in the acid solution to Fe3+ by the oxidizing device using a gaseous oxidant; and a feeding start step of, upon switching from pickling of the first steel plate portion to pickling of the second steel plate portion, starting feeding of a liquid oxidant for oxidizing Fe2+ in the acid solution to Fe3+ to any of the at least one pickling tank or to t

Abstract: A pickling apparatus for pickling a strip of metal being conveyed is equipped with: a pickling tank for storing an acid solution; a surrounding part disposed in the pickling tank so as to surround the strip immersed in the acid solution in the pickling tank; and an oxidant supply part for supplying a liquid oxidant toward an inside of the surrounding part.

Abstract: Novel substituted type peptides of WT1 wherein the cysteine residue is substituted with a defined amino acid residue, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. Peptides which comprise an amino acid sequence of the formula: X-Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO: 4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe, or Asn, and Y represents Tyr or Met, and which has an activity to induce CTLs, polynucleotides encoding said peptides, cancer vaccines which comprise those peptides or polynucleotides as an active ingredient, and the like are disclosed.

Abstract: Novel substituted type peptides of WT1 wherein the cysteine residue is substituted with a defined amino acid residue, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. Peptides which comprise an amino acid sequence of the formula: X—Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO: 4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe, or Asn, and Y represents Tyr or Met, and which has an activity to induce CTLs, polynucleotides encoding said peptides, cancer vaccines which comprise those peptides or polynucleotides as an active ingredient, and the like are disclosed.

Abstract: A hydroxamic acid derivative represented by formula (1) or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which has a matrix metalo-proteinase inhibitor.

Abstract: An isoxazole derivative represented by the formula: ##STR1## or a pharmaceutically acceptable salt thereof useful as a therapeutic drug for auto-immune diseases and inflammatory diseases.

Abstract: Novel phenylserine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions, and a process for preparing the compounds are disclosed. The phenylserine derivatives and pharmaceutically acceptable acid addition salts are capable of inhibiting the biosynthesis of leucotrienes and/or antagonistic activity against SRS-A and hence are useful for prophylaxis and treatment of various allergic diseases (e.g. bronchial asthma, allergic nasitis, urticaria), ischemic heart diseases, ischemic encephalopathy, inflammation, or the like.