Patents by Inventor Masashi Ohmi

Masashi Ohmi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-HYDROXYOXINDOLE DERIVATIVES AS CRHR2 ANTAGONIST
    Publication number: 20240018103
    Abstract: The present invention relates to 3-hydroxyoxindole derivatives which have antagonistic activities against CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR2 is involved.
    Type: Application
    Filed: September 30, 2021
    Publication date: January 18, 2024
    Applicant: RaQualia Pharma Inc.
    Inventors: Kazuo ANDO, Masashi OHMI, Ryohei MAGARA
  • Fused cyclic urea derivatives as CRHR2 antagonist
    Patent number: 11802120
    Abstract: The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: October 31, 2023
    Assignee: RaQualia Pharma Inc.
    Inventors: Masashi Ohmi, Takeshi Matsushita, Kazuo Ando, Ryuichi Yamaguchi, Yutaka Fukumoto, Ryohei Magara, Tatsuya Yamagishi, Mikito Takefuji
  • Biaryloxy derivatives as TTX-S blockers
    Patent number: 11020381
    Abstract: The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channel is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: June 1, 2021
    Assignees: RaQualia Pharma Inc., XuanZhu Pharma Co., Ltd.
    Inventors: Kiyoshi Kawamura, Tatsuya Yamagishi, Yuji Shishido, Mikio Morita, Ryuichi Yamaguchi, Masashi Ohmi
  • FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST
    Publication number: 20210078975
    Abstract: The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.
    Type: Application
    Filed: April 9, 2019
    Publication date: March 18, 2021
    Applicants: RaQualia Pharma Inc., National University Corporation Tokai National Higher Education and Research System
    Inventors: Masashi OHMI, Takeshi MATSUSHITA, Kazuo ANDO, Ryuichi YAMAGUCHI, Yutaka FUKUMOTO, Ryohei MAGARA, Tatsuya YAMAGISHI, Mikito TAKEFUJI
  • BIARYLOXY DERIVATIVES AS TTX-S BLOCKERS
    Publication number: 20200230123
    Abstract: The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channel is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.
    Type: Application
    Filed: August 31, 2018
    Publication date: July 23, 2020
    Applicants: RaQualia Pharma Inc., XuanZhu Pharma Co., Ltd.
    Inventors: Kiyoshi KAWAMURA, Tatsuya YAMAGISHI, Yuji SHISHIDO, Mikio MORITA, Ryuichi YAMAGUCHI, Masashi OHMI
  • AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS
    Publication number: 20180339993
    Abstract: The present invention relates to azaspiro derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor,
    Type: Application
    Filed: July 31, 2018
    Publication date: November 29, 2018
    Applicant: RaQualia Pharma Inc.
    Inventors: Yuji SHISHIDO, Masashi OHMI, Kazuo ANDO
  • IMIDAZOLINONE DERIVATIVES AS TRPM8 ANTAGONISTS
    Publication number: 20180305341
    Abstract: The present invention relates to imidazolinone derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
    Type: Application
    Filed: September 12, 2016
    Publication date: October 25, 2018
    Applicant: RaQualia Pharma Inc.
    Inventors: Yuji SHISHIDO, Masashi OHMI
  • Azaspiro derivatives as TRPM8 antagonists
    Patent number: 10093678
    Abstract: The present invention relates to azaspiro derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: October 9, 2018
    Assignee: RaQualia Pharma Inc.
    Inventors: Yuji Shishido, Masashi Ohmi, Kazuo Ando
  • AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS
    Publication number: 20170002016
    Abstract: The present invention relates to azaspiro derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
    Type: Application
    Filed: March 16, 2015
    Publication date: January 5, 2017
    Applicant: RaQualia Pharma Inc.
    Inventors: Yuji SHISHIDO, Masashi OHMI, Kazuo ANDO
  • Sulfamoyl benzoic acid heterobicyclic derivatives as TRPM8 antagonists
    Patent number: 8829026
    Abstract: The present invention relates to sulfamoyl benzoic acid heterobicyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPMb8 receptor.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: September 9, 2014
    Assignee: RaQualia Pharma Inc.
    Inventors: Kiyoshi Kawamura, Yuji Shishido, Masashi Ohmi
  • Oxyindole derivatives with motilin receptor agonistic activity
    Patent number: 8697877
    Abstract: The present invention relates to novel oxyindole derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the motilin receptor (GPR38).
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: April 15, 2014
    Assignee: RaQualia Pharma Inc.
    Inventors: Masaki Sudo, Yasuhiro Iwata, Yoshimasa Arano, Madoka Jinno, Masashi Ohmi, Hirohide Noguchi
  • SULFAMOYL BENZOIC ACID HETEROBICYCLIC DERIVATIVES AS TRPM8 ANTAGONISTS
    Publication number: 20130210858
    Abstract: The present invention relates to sulfamoyl benzoic acid heterobicyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
    Type: Application
    Filed: October 3, 2011
    Publication date: August 15, 2013
    Applicant: Raqualia Pharma Inc.
    Inventors: Kiyoshi Kawamura, Yuji Shishido, Masashi Ohmi
  • SULFAMOYL BENZOIC ACID DERIVATIVES AS TRPM8 ANTAGONISTS
    Publication number: 20120094964
    Abstract: The present invention relates to sulfamoyl benzoic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
    Type: Application
    Filed: May 6, 2010
    Publication date: April 19, 2012
    Inventors: Tadashi Inoue, Masashi Ohmi, Kiyoshi Kawamura, Kazuo Ando, Yuji Shishido
  • OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY
    Publication number: 20110312933
    Abstract: The present invention relates to novel oxyindole derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the motilin receptor (GPR38).
    Type: Application
    Filed: March 1, 2010
    Publication date: December 22, 2011
    Inventors: Masaki Sudo, Yasuhiro Iwata, Yoshimasa Arano, Madoka Jinno, Masashi Ohmi, Hirohide Noguchi