Patents by Inventor Masashi Shimizu

Masashi Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240218035
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Application
    Filed: February 1, 2024
    Publication date: July 4, 2024
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Publication number: 20240184227
    Abstract: In a two-component developer, toner particles include toner mother particles and external additive particles including strontium titanate particles. A first percentage content being a percentage content of the strontium titanate particles to the mass of the toner mother particles is 0.30-0.90% by mass. The carrier particles include carrier cores and coat layers. The coat layers contain barium titanate particles and a coating resin including a silicone resin. The barium titanate particles have a number average primary particle diameter of 100-500 nm. A second percentage content being a percentage content of the coat layers to the mass of the carrier cores is 2.0-4.0% by mass. A third percentage content being a percentage content of the barium titanate to the mass of the coating resin satisfies formula (1) “(X×10)?Z?45.0”. In formula (1), X represents the first percentage content and Z represents the third percentage content.
    Type: Application
    Filed: March 31, 2022
    Publication date: June 6, 2024
    Applicant: KYOCERA Document Solutions Inc.
    Inventors: Kohei TERASAKI, Tamotsu SHIMIZU, Yusuke KURANO, Masashi YAMASHITA, Yuma UCHIHASHI
  • Publication number: 20240069469
    Abstract: An image forming apparatus includes a developer, a development device, and an image bearing member. The developer includes an initial developer containing an initial carrier and a replenishment developer containing a replenishment carrier. The initial carrier has a surface roughness Sa1 of at least 0.3 ?m and no greater than 1.0 ?m. A ratio Sa1/Sa2 of the surface roughness Sa1 of the initial carrier to a surface roughness Sa2 of the replenishment carrier is at least 1.2 and no greater than 3.4. The packing volume Vp calculated from equation (1)“Vp=100×Y/(Z×DS)” was at least 40% and no greater than 70%. In equation (1), Y represents an amount of the developer conveyed by a developer bearing member. Z represents an apparent density of the initial developer. DS represents a width of a space between the developer bearing member and the image bearing member.
    Type: Application
    Filed: August 25, 2023
    Publication date: February 29, 2024
    Applicant: KYOCERA Document Solutions Inc.
    Inventors: Masashi FUJISHIMA, Tamotsu SHIMIZU, Asami SASAKI, Eriko TAKEUCHI
  • Publication number: 20230207287
    Abstract: A sample cartridge carrier apparatus is coupled with a focused ion beam processing apparatus (FIB processing apparatus). A guide mechanism is configured to guide a series of movements of a sample cartridge holder to allow a sample cartridge to be held by a carrier base on a sub stage. Sub cooling equipment is configured to cool the sample cartridge via the sub stage. A carrier mechanism carries the carrier base between the sub stage and a main stage.
    Type: Application
    Filed: December 20, 2022
    Publication date: June 29, 2023
    Inventor: Masashi Shimizu
  • Patent number: 11548926
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: January 10, 2023
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 11466065
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: October 11, 2022
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Publication number: 20220267393
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 11325960
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: May 10, 2022
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 11168123
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: November 9, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 11127561
    Abstract: A secondary storage container is a member which surrounds a primary storage container. A vaporized coolant generated in a primary storage space flows into and is stored in the secondary storage container. Radiant heat is blocked by the secondary storage container in a cooled state. Heat transferred to the primary storage container is reduced by a heat conducting path including the secondary storage container.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: September 21, 2021
    Assignee: JEOL Ltd.
    Inventor: Masashi Shimizu
  • Publication number: 20210110993
    Abstract: A secondary storage container is a member which surrounds a primary storage container. A vaporized coolant generated in a primary storage space flows into and is stored in the secondary storage container. Radiant heat is blocked by the secondary storage container in a cooled state. Heat transferred to the primary storage container is reduced by a heat conducting path including the secondary storage container.
    Type: Application
    Filed: October 14, 2020
    Publication date: April 15, 2021
    Inventor: Masashi Shimizu
  • Patent number: 10504690
    Abstract: A sample holder capable of limiting X-rays accepted into an X-ray detector is provided. The sample holder is for use in an electron microscope equipped with a polepiece assembly and a semiconductor detector. The sample holder includes: a sample stage on which a sample is held; and a shield plate. When the sample stage has been introduced in the sample chamber of the electron microscope, the shield plate is located between the polepiece assembly and the semiconductor detector.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: December 10, 2019
    Assignee: JEOL Ltd.
    Inventors: Kazuki Yagi, Takeo Sasaki, Ichiro Onishi, Shuichi Yuasa, Masashi Shimizu
  • Publication number: 20190062390
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Application
    Filed: March 15, 2017
    Publication date: February 28, 2019
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Publication number: 20180374671
    Abstract: A sample holder capable of limiting X-rays accepted into an X-ray detector is provided. The sample holder is for use in an electron microscope equipped with a polepiece assembly and a semiconductor detector. The sample holder includes: a sample stage on which a sample is held; and a shield plate. When the sample stage has been introduced in the sample chamber of the electron microscope, the shield plate is located between the polepiece assembly and the semiconductor detector.
    Type: Application
    Filed: June 13, 2018
    Publication date: December 27, 2018
    Inventors: Kazuki Yagi, Takeo Sasaki, Ichiro Onishi, Shuichi Yuasa, Masashi Shimizu
  • Publication number: 20180166252
    Abstract: There is provided a liner tube capable of reducing the effects of magnetic field variations on an electron beam. The liner tube (10) is disposed inside the electron optical column (2) of an electron microscope (100). The interior of the tube (10) forms a path for the electron beam (EB). The liner tube (10) has a first cylindrical member (110) that is made of copper, gold, silver, or an alloy consisting principally of one of these metals.
    Type: Application
    Filed: December 8, 2016
    Publication date: June 14, 2018
    Inventors: Hidetaka Sawada, Yu Jimbo, Masashi Shimizu
  • Patent number: 9997327
    Abstract: There is provided a liner tube capable of reducing the effects of magnetic field variations on an electron beam. The liner tube (10) is disposed inside the electron optical column (2) of an electron microscope (100). The interior of the tube (10) forms a path for the electron beam (EB). The liner tube (10) has a first cylindrical member (110) that is made of copper, gold, silver, or an alloy consisting principally of one of these metals.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: June 12, 2018
    Assignee: JEOL Ltd.
    Inventors: Hidetaka Sawada, Yu Jimbo, Masashi Shimizu
  • Patent number: 8789909
    Abstract: An ink jet recording apparatus includes a recording head configured to discharge ink onto a recording medium, a carriage on which the recording head is mounted and which is configured to make a reciprocating movement, a cutter unit mounted on the carriage and configured to cut the recording medium, a detection unit mounted on the carriage and configured to detect a distance to the recording medium, and a control unit configured to control an operation of the recording apparatus. The ink jet recording apparatus includes a first process for detecting an amount of a change in the distance to the recording medium by the detection unit when the recording medium is cut by the cutter unit, and a second process for detecting the distance to the recording medium by the detection unit while the cutter unit is retracted if the change amount equal to or more than a predetermined value is detected in the first process.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: July 29, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventor: Masashi Shimizu
  • Patent number: 8262008
    Abstract: A seat belt pretension with improved piston sealing performance. A piston has an expanding section formed at one end thereof contacting a force transmission component. When gas pressure resulting from reactive gas generated by a gas generator causes the piston to exert a pressing force on the force transmission component in the event of an emergency, the expanding section expands toward the inner circumferential surface of a pipe due to the gas pressure. As a result, the outer circumferential surface of the expanding section in the piston comes into contact with the inner circumferential surface of the pipe in a more efficient manner, resulting in enhanced sealing between the piston and the inner circumferential surface of the pipe. This prevents reactive gas from losing gas pressure, thereby allowing the gas pressure to more efficiently act on the piston.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: September 11, 2012
    Assignee: Takata Corporation
    Inventors: Masahiro Shiotani, Masashi Shimizu
  • Patent number: 8137963
    Abstract: A vector of the present invention is a vector for amplifying a target gene in a mammalian cell, the vector including an amplification-activating fragment, which is a partial fragment of a mammalian replication initiation region and has a gene amplification activity site, and a mammalian nuclear matrix attachment region. In the case where the mammalian replication initiation region as described above derives from a c-myc locus, for example, the above-described partial fragment at least contains a duplex unwinding element and a topoisomerase II-binding domain. The vector as described above improves gene transfer efficiency and gene amplification efficiency compared with the existing high gene amplification systems. Thus, a method whereby a “high gene amplification system” developed by the inventors can amplify a target gene with better gene transfer efficiency and a vector to be used in this method are provided.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: March 20, 2012
    Assignee: Hiroshima University
    Inventors: Noriaki Shimizu, Toshihiko Hashizume, Masashi Shimizu
  • Publication number: 20110205279
    Abstract: An ink jet recording apparatus includes a recording head configured to discharge ink onto a recording medium, a carriage on which the recording head is mounted and which is configured to make a reciprocating movement, a cutter unit mounted on the carriage and configured to cut the recording medium, a detection unit mounted on the carriage and configured to detect a distance to the recording medium, and a control unit configured to control an operation of the recording apparatus. The ink jet recording apparatus includes a first process for detecting an amount of a change in the distance to the recording medium by the detection unit when the recording medium is cut by the cutter unit, and a second process for detecting the distance to the recording medium by the detection unit while the cutter unit is retracted if the change amount equal to or more than a predetermined value is detected in the first process.
    Type: Application
    Filed: February 18, 2011
    Publication date: August 25, 2011
    Applicant: CANON KABUSHIKI KAISHA
    Inventor: Masashi Shimizu