Patents by Inventor Masateru Miyano

Masateru Miyano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenyl amidine alkanoic acids useful as platelet aggregation inhibitors
    Patent number: 5646183
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 8, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman Anthony Abood, Robert Everett Manning, Masateru Miyano
  • Phenyl amidine lactones useful as platelet aggregation inhibitors
    Patent number: 5612355
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: March 18, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert E. Manning, Masateru Miyano
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5552431
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl amidines derivatives.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: September 3, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert B. Garland, Masateru Miyano
  • Peptide mimics useful as platelet aggregation inhibitors
    Patent number: 5550159
    Abstract: This invention relates to compounds having the following formula ##STR1## or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: August 27, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Robert B. Garland, Masateru Miyano, Joseph G. Rico, Thomas E. Rogers, Jeffery A. Zablocki
  • Method of inhibiting platelet aggregation using phenyl amidine thio derivatives
    Patent number: 5543425
    Abstract: This invention relates to a method of inhibiting platelet aggregation comprising administering compounds having the following formula ##STR1##
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: August 6, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Richard J. Lindmark, Masateru Miyano, Joseph G. Rico
  • Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors
    Patent number: 5504106
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: April 2, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert E. Manning, Masateru Miyano
  • Phenyl amidines derivatives useful as platelet aggregation inhibitors
    Patent number: 5481021
    Abstract: This invention relates to phenyl amidine derivatives having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 2, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki, Lori A. Schretzman
  • Peptide mimics useful as platelet aggregation inhibitors
    Patent number: 5453440
    Abstract: This invention relates to compounds having the following formula ##STR1## or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: September 26, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Robert B. Garland, Masateru Miyano, Joseph G. Rico, Thomas E. Rogers, Jeffery A. Zablocki
  • Phenyl amidines lactones useful as platelet aggregation inhibitors
    Patent number: 5441974
    Abstract: This invention relates to compounds having the following formula ##STR1## wherein Z is a lactone or a lactone which is fused to a benzene ring which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
    Type: Grant
    Filed: May 25, 1994
    Date of Patent: August 15, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Thomas E. Rogers, Masateru Miyano, Joseph G. Rico
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5424334
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl amidines derivatives.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: June 13, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert B. Garland, Masateru Miyano
  • Phenyl amidine thio derivatives useful as platelet aggregation inhibitors
    Patent number: 5409939
    Abstract: This invention relates to compounds having the following formula ##STR1## which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine thio derivatives.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: April 25, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Richard J. Lindmark, Masateru Miyano, Joseph G. Rico
  • Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
    Patent number: 5264457
    Abstract: This invention relates to compounds having the following formula ##STR1## which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine sulfones derivatives.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: November 23, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Joseph G. Rico, Masateru Miyano
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5220050
    Abstract: This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: June 15, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Dudley E. McMackins, Joseph G. Rico, Foe S. Tjoeng, Mihaly V. Toth, Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki
  • Methods for the use of thromboxane A.sub.2 antagonists
    Patent number: 5106870
    Abstract: This invention relates to several thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids, pharmaceutical compositions employing them and methods of their use.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: April 21, 1992
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Pyridyl peptide mimetic compounds which are useful platelet-aggregation inhibitors
    Patent number: 5091396
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8,y=0 to 4,W=CH.sub.2 --CH.sub.2 or C.dbd.CH,Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl,R=C.sub.1-6 alkyl,Ar=a nitrogen-containing heterocyclic group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: January 7, 1991
    Date of Patent: February 25, 1992
    Assignees: Monsanto Co., G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Steven P. Adams, Robert B. Garland, Masateru Miyano
  • Process for preparing thromboxane A.sub.2 antagonists
    Patent number: 5055582
    Abstract: This invention relates to a process for preparing useful thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)thioxomethyl]hydrazono]ethyl]-1.alpha. ,4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha.,7a.alpha.-4.alpha.,7.alpha.-meth ano-2H-inden-2-ones.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: October 8, 1991
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Indolyl platelet-aggregation inhibitors
    Patent number: 5037808
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8,y=0 to 4,W=CH.sub.2 --CH.sub.2 or CH.dbd.CH,Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl,R=C.sub.1-6 alkyl,Ar=a nitrogen-containing heterocyclic group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: April 23, 1990
    Date of Patent: August 6, 1991
    Assignees: Monsanto Co., G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Steven P. Adams, Robert B. Garland, Masateru Miyano
  • Novel methods of manufacturing thromboxane A.sub.2 antagonists
    Patent number: 4992581
    Abstract: This invention relates to several novel methods of manufacturing thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: February 12, 1991
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Benzopyran intermediates for use in manufacturing thromboxane A.sub.2 antagonists
    Patent number: 4992563
    Abstract: This invention relates to several intermediates useful in preparing thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-1.alpha ., 4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha., 7a.alpha.-4.alpha.,7.alpha.-methano-2H-inden-2-ones.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: February 12, 1991
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Thromboxane A.sub.2 antagonists and pharmaceutical compositions thereof
    Patent number: 4973604
    Abstract: This invention relates to several thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids, pharmaceutical compositions employing them and methods of their use.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: November 27, 1990
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano