Abstract: This invention relates to methods for treating hearing loss associated with loss of cochlear hair cells, e.g., caused by noise exposure, using certain gamma secretase inhibitors, in post-neonatal animals, e.g., adolescents and adults.

Abstract: An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein R1 to R7 are each independently selected from a hydrogen atom, a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, and a phenyl group; wherein R1 is a C1-6 alkyl or a C3-6 alkynyl, R2 is H, —CH2-OH or —CH2—CH2OH, and X is ?O, (H, H) or (H, OH).

Abstract: An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein R1 to R7 are each independently selected from a hydrogen atom, a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, and a phenyl group; wherein R1 is a C1-6 alkyl or a C3-6 alkynyl, R2 is H, —CH2—OH or —CH2—CH2—OH, and X is ?O, (H, H) or (H, OH).

Abstract: A battery cooling structure includes a cooling plate and an electrically insulative sheet. The cooling plate is to support a cooling surface of a battery module to cool the battery module including a plurality of battery cells arranged side by side. The electrically insulative sheet has an electrical non-conductivity and is disposed between the cooling surface of the battery module and the cooling plate to transfer heat from the cooling surface to the cooling plate.

Abstract: This invention relates to methods for treating hearing loss associated with loss of cochlear hair cells, e.g., caused by noise exposure, using certain gamma secretase inhibitors, in post-neonatal animals, e.g., adolescents and adults.

Abstract: Described are transgenic animals for conditional and inducible cell targeting, that express a dimerizable conditional-STOP caspase 3 transgene.

Abstract: An information control device for an electric vehicle including a vehicle-mounted battery that is charged with electric power supplied from a power supply provided at an outside of the vehicle includes a lock operation detector, a remaining power detector, and a notification controller. The lock operation detector is configured to detect a lock operation of a door lock mechanism of the vehicle. The remaining power detector is configured to detect a remaining power amount of the vehicle-mounted battery. The notification controller is configured to control a notifying device to make a notification to the outside of the vehicle. The notification is indicative of information that recommends power charge of the vehicle-mounted battery if the remaining power amount is small when the door lock mechanism has been locked or is to be locked, based on detection results of the lock operation detector and the remaining power detector.

Abstract: An information control device for an electric vehicle including a vehicle-mounted battery that is charged with electric power supplied from a power supply provided at an outside of the vehicle includes a lock operation detector, a remaining power detector, and a notification controller. The lock operation detector is configured to detect a lock operation of a door lock mechanism of the vehicle. The remaining power detector is configured to detect a remaining power amount of the vehicle-mounted battery. The notification controller is configured to control a notifying device to make a notification to the outside of the vehicle. The notification is indicative of information that recommends power charge of the vehicle-mounted battery if the remaining power amount is small when the door lock mechanism has been locked or is to be locked, based on detection results of the lock operation detector and the remaining power detector.

Abstract: A motor is provided with: an inner rotor having inner permanent magnets arranged in a peripheral direction and an outer rotor having outer permanent magnets arranged in the peripheral direction, the mutual axes of rotation of the inner rotor and the outer rotor being arranged coaxially, and a rotating device capable of making at least one of the inner rotor and the outer rotor rotate around the axes of rotation so as to change the relative phase between the rotors, wherein the rotating device includes: a first member which is integrally and rotatably provided with respect to the outer rotor; and a second member which is integrally and rotatably provided with respect to the inner rotor and which defines pressure chambers inside the inner rotor with the first member, and wherein a working fluid is supplied to the pressure chambers, thereby changing the relative phase between the rotors.

Abstract: A motor is provided with: an inner rotor having inner permanent magnets arranged in a peripheral direction and an outer rotor having outer permanent magnets arranged in the peripheral direction, the mutual axes of rotation of the inner rotor and the outer rotor being arranged coaxially, and a rotating device capable of making at least one of the inner rotor and the outer rotor rotate around the axes of rotation so as to change the relative phase between the rotors, wherein the rotating device includes: a first member which is integrally and rotatably provided with respect to the outer rotor; and a second member which is integrally and rotatably provided with respect to the inner rotor and which defines pressure chambers inside the inner rotor with the first member, and wherein a working fluid is supplied to the pressure chambers, thereby changing the relative phase between the rotors.

Abstract: This electric motor is provided with an inner periphery side rotor, an outer periphery side rotor, and a rotating device that can change a relative phase between these rotors by rotating at least one of them about a rotational axis thereof. The rotating device is provided with a first member integrally and rotatably provided to the outer periphery side rotor, and a second member integrally fixed on an inside of the inner periphery side rotor which together with the first member defines a pressure chamber on the inside of the inner periphery side rotor. The rotating device changes a relative phase between the inner periphery side rotor and the outer periphery side rotor by supplying a hydraulic fluid to the pressure chamber. The rotating device is further provided with a linking passage that leaks the hydraulic fluid supplied to the pressure chamber to an outside of the pressure chamber.

Abstract: An electric motor comprising an inner periphery side rotor provided with inner peripheral permanent magnets with unlike poles, which are disposed alternately along a circumferential direction of the inner periphery side rotor, an outer periphery side rotor provided with outer peripheral permanent magnets with unlike poles, which are disposed alternately along a circumferential direction of the outer periphery side rotor, and a rotating device that varies a relative phase between the inner periphery side rotor and the outer periphery side rotor by rotating at least the inner periphery side rotor or the outer periphery side rotor around the rotational axis. The outer peripheral side rotor is arranged such that a rotational axis thereof is coaxial with a rotational axis of the inner periphery side rotor. The rotating device sets a variable width of the relative phase between the inner periphery side rotor and the outer periphery side rotor within a range of an electrical angle of below 180°.

Abstract: Described are transgenic animals for conditional and inducible cell targeting, that express a dimerizable conditional-STOP caspase 3 transgene.

Abstract: A therapeutic and/or preventive agent for inner ear disorders comprising an IL-6 antagonist, preferably an anti-IL-6R antibody, as an active ingredient.

Abstract: A therapeutic and/or preventive agent for inner ear disorders comprising an IL-6 antagonist, preferably an anti-IL-6R antibody, as an active ingredient.

Abstract: This electric motor is provided with: an inner periphery side rotor provided with inner peripheral permanent magnets with unlike poles, which are disposed alternately along a circumferential direction; an outer periphery side rotor provided with outer peripheral permanent magnets with unlike poles, which are disposed alternately along a circumferential direction, the outer periphery side rotor being arranged such that a rotational axis thereof is coaxial with a rotational axis of the inner periphery side rotor; and a rotating device that varies a relative phase between the inner periphery side rotor and the outer periphery side rotor by rotating at least the inner periphery side rotor or the outer periphery side rotor around the rotational axis, and sets a variable width of the relative phase between the inner periphery side rotor and the outer periphery side rotor within a range of an electrical angle of below 180°.

Abstract: This electric motor is provided with an inner periphery side rotor, an outer periphery side rotor, and a rotating device that can change a relative phase between these rotors by rotating at least one of them about a rotational axis thereof. The rotating device is provided with a first member integrally and rotatably provided to the outer periphery side rotor, and a second member integrally fixed on an inside of the inner periphery side rotor which together with the first member defines a pressure chamber on the inside of the inner periphery side rotor. The rotating device changes a relative phase between the inner periphery side rotor and the outer periphery side rotor by supplying a hydraulic fluid to the pressure chamber. The rotating device is further provided with a linking passage that leaks the hydraulic fluid supplied to the pressure chamber to an outside of the pressure chamber.

Abstract: In a vehicular drive system for a hybrid vehicle, in which driving forces of an engine and a motor are transmitted through a power transmission mechanism to driven wheels, a common oil stored in a transmission case and a motor case is used for lubricating the power transmission mechanism and the motor. During travel by using an engine, when a synchromesh mechanism operated by a shift fork isolates the motor from the power transmission mechanism, an oil return hole blocking rod, provided in the shift fork, blocks an oil return hole providing communication between the motor case and the transmission case, thereby preventing oil in the motor case from flowing into the transmission case, to lower oil level in the transmission case. Thus, during travel of the hybrid vehicle, driving force loss due to motor drag resistance and oil stirring resistance is minimized.

Abstract: A vehicle driving system includes a pulley shaft synchronously rotating with a crankshaft of an engine, an auxiliary unit drive shaft driving an auxiliary unit, a planetary gear mechanism portion having elements such as a sun gear, a pinion carrier and a ring gear. The pulley shaft and the auxiliary unit drive shaft are adapted for connection to any two of the elements, respectively. The motor connecting to the remaining element of the planetary gear mechanism portion. A lock-up clutch connecting together the two or more elements of the planetary gear mechanism portion. A one-way clutch for restricting the rotation of the auxiliary unit drive shaft in one direction, wherein the planetary gear mechanism portion, the motor, the lock-up clutch, and the auxiliary unit drive shaft are coaxially disposed in line.

Abstract: In a vehicular drive system for a hybrid vehicle, in which driving forces of an engine and a motor are transmitted through a power transmission mechanism to driven wheels, a common oil stored in a transmission case and a motor case is used for lubricating the power transmission mechanism and the motor. During travel by means of an engine, when a synchromesh mechanism operated by a shift fork isolates the motor from the power transmission mechanism, an oil return hole blocking rod, provided in the shift fork, blocks an oil return hole providing communication between the motor case and the transmission case, thereby preventing oil in the motor case from flowing into the transmission case, to lower oil level in the transmission case. Thus, during travel of the hybrid vehicle, driving force loss due to motor drag resistance and oil stirring resistance is minimized.