Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: In a method of assembling a lower electrode mechanism, after a support tube and an electrode holder are integrally assembled, a cylindrical assembly case is inserted into the support tube from the bottom to align an elongated hole of the support tube with an elongated hole of the assembly case to assemble them. The rod assembly is inserted into the tube from the upper part of the electrode holder. The lower end of the rod of the rod assembly is placed to a position visible through the elongated hole of the support tube. A protruding bar is inserted into the support tube, the base end of the protruding bar is fixed to the lower end of the rod, and the slide sensor is attached to the support tube while the distal end of the protruding bar and detector of the slide sensor are connected.

Abstract: An object of the present invention is to reduce the size of an entire device by simplifying a device configuration, and also accurately measure the stroke position of a rod. A lower electrode 2 is mounted on an upper portion of an electrode holder tube 3. A rod 4 that is vertically movable within the electrode holder tube 3 is divided into a first rod 4a and a second rod 4b. The rod 4 is urged upward by a compressed spring 5 that is interposed between a spring receiving seat 14 fixed to the upper end surface of the second rod 4b and an insulating adapter 7. Pressurized air supplied from a pressurized air supply pipe 15 to assist the urging force is received by a pressure receiving portion on the lower surface of the spring receiving seat 14, thereby assisting the spring 5 to urge the rod 4 upward. A magnetic sensor 10 is disposed below the second rod 4b, and a lower end portion of the second rod 4b is directly connected to a detector 17 of the magnetic sensor 10.

Abstract: A female connector including: a cylindrical core member having a luer taper on a distal inner surface thereof and a tube bonding portion formed on a proximal end inner surface and being formed with a flange at a distal extremity thereof; a cylindrical housing having a male screw formed on an outer surface thereof and mounted to an outer periphery of the core member without being fixed, and a stopper fixed at a position apart from the flange of the core member, wherein the distance (L1) between the flange and the stopper is larger than the length (L2) of the housing in the axial direction when a male connector is connected to the female connector.

Abstract: A curved electrode includes an installing portion to be installed in an electrode holder, an offset portion by which the offset amount is obtained, and a tip portion which comes into contact with the material to be welded W, the portions being formed separately and assembled together. A vertical hole and a horizontal hole are formed within the installing portion, an axis hole is formed within the offset portion, and a water supply tube is inserted into a cooling hole which is constructed of the vertical hole, the horizontal hole and the axis hole. C-chamfering or R-chamfering is conducted to a corner where the vertical hole and the horizontal hole intersect. An object of the present invention is to provide a curved electrode which can be manufactured easily at a low cost, and if a part of it is damaged, only that part needs to be replaced at a low cost. The durability of the curved electrode can be improved at the same time.

Abstract: A curved electrode includes an installing portion to be installed in an electrode holder, an offset portion by which the offset amount is obtained, and a tip portion which comes into contact with the material to be welded W, the portions being formed separately and assembled together. A vertical hole and a horizontal hole are formed within the installing portion, an axis hole is formed within the offset portion, and a water supply tube is inserted into a cooling hole which is constructed of the vertical hole, the horizontal hole and the axis hole. C-chamfering or R-chamfering is conducted to a corner where the vertical hole and the horizontal hole intersect. An object of the present invention is to provide a curved electrode which can be manufactured easily at a low cost, and if a part of it is damaged, only that part needs to be replaced at a low cost. The durability of the curved electrode can be improved at the same time.

Abstract: A female connector including: a cylindrical core member having a luer taper on a distal inner surface thereof and a tube bonding portion formed on a proximal end inner surface and being formed with a flange at a distal extremity thereof; a cylindrical housing having a male screw formed on an outer surface thereof and mounted to an outer periphery of the core member without being fixed, and a stopper fixed at a position apart from the flange of the core member, wherein the distance (L1) between the flange and the stopper is larger than the length (L2) of the housing in the axial direction when a male connector is connected to the female connector.

Abstract: The present invention relates to a nut positioning pin disposed on a lower electrode for the projection welding of a nut. The present invention increases cooling and positioning accuracy, prevents entrance of sputtering particles, and increases the detecting accuracy. The present invention comprises an electrode holder (2) of a double-tube structure having a cooling water passage, a guide ring (13) for guiding a coupling rod (7) for vertical movement, an air passage (m) for preventing the entrance of sputtering particles, a coupling block (28) and a magnetic shield, which comprises a magnetic member for preventing a magnetic detecting element from being affected by an external magnetic field. The present invention accurately guides cooling water and the coupling rod in the electrode holder and prevents sputtering particles from entering the electrode holder, and prevents a detector from being adversely influenced by an external magnetic field for increased detecting accuracy.

Abstract: The present invention relates to a nut positioning pin disposed on a lower electrode for the projection welding of a nut. The present invention increases cooling and positioning accuracy, prevents entrance of sputtering particles, and increases the detecting accuracy. The present invention comprises an electrode holder (2) of a double-tube structure having a cooling water passage, a guide ring (13) for guiding a coupling rod (7) for vertical movement, an air passage (m) for preventing the entrance of sputtering particles, a coupling block (28) and a magnetic shield, which comprises a magnetic member for preventing a magnetic detecting element from being affected by an external magnetic field. The present invention accurately guides cooling water and the coupling rod in the electrode holder and prevents sputtering particles from entering the electrode holder, and prevents a detector from being adversely influenced by an external magnetic field for increased detecting accuracy.

Abstract: Welding contact tip having a wire passage for a welding wire in a center thereof, comprising a tip body and a tip end which are detachable from each other by screw-in type or taper force-in type structure, the tip body being composed of brass, aluminum, chromate copper, zirconium copper, zirconium chromate copper or phosphor bronze, the tip end being composed of copper, chromate copper, zirconium chromate copper, zirconium copper, silver tungsten, copper tungsten, alumina dispersed copper, beryllium copper or nickel beryllium copper, for prolonging a service life of the contact tip and reducing the total production cost thereof. Particularly brass is suitable for the tip body and chromate copper or zirconium chromate copper is suitable for the tip end. The wire passage in the tip body has a diameter 1.03-1.50 times a wire diameter and the wire passage in the tip end has a diameter 1.03-1.25 times the wire diameter.