Patents by Inventor Masato Kanemaki

Masato Kanemaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NONHUMAN ANIMAL AND USE FOR SAME
    Publication number: 20220378024
    Abstract: A genetically modified non-human animal in which an auxin-inducible degron system controls degradation of a target protein in a living body includes: a chromosome containing a first nucleic acid that encodes a mutant TIR1 family protein having a mutation at an auxin-binding site and having affinity to an auxin analog.
    Type: Application
    Filed: April 30, 2020
    Publication date: December 1, 2022
    Inventors: Masato KANEMAKI, Ken-ichiro HAYASHI, Naomi KITAMOTO, Yumiko SAGA, Rieko AJIMA
  • AUXIN-INDUCIBLE DEGRON SYSTEM KIT AND USE THEREOF
    Publication number: 20220380782
    Abstract: An auxin-inducible degron system kit that controls degradation of a target protein in a non-plant-derived eukaryotic cell, the kit containing a first nucleic acid that encodes a mutant TIR1 family protein having a mutation at an auxin-binding site, an auxin analog that has an affinity to the mutant TIR1 family protein and a second nucleic acid that encodes a degradation tag containing at least a part of an Aux/IAA family protein and having an affinity to a complex of the mutant TIR1 family protein and the auxin analog.
    Type: Application
    Filed: April 30, 2020
    Publication date: December 1, 2022
    Inventors: Masato KANEMAKI, Ken-ichiro HAYASHI
  • METHOD FOR SITE-SPECIFIC INSERTION OF FOREIGN DNA INTO A GENOME IN AN ANIMAL CELL AND A CELL OBTAINED USING SAME
    Publication number: 20180320186
    Abstract: A method is provided for site-specific insertion of foreign DNA into a genome in an animal cell, including (1) a step of constructing a donor plasmid in which DNA of 100 bp to 300 bp having a sequence homologous to an insertion site on a genome is ligated to the upstream and downstream of foreign DNA of 0.1 kbp to 10 kbp, and (2) a step of inserting the foreign DNA of 0.1 kbp to 10 kbp into a target site on the genome by a homology-directed repair-based genome editing method using the obtained donor plasmid.
    Type: Application
    Filed: March 23, 2016
    Publication date: November 8, 2018
    Inventors: Masato Kanemaki, Toyoaki Natsume
  • METHOD FOR INDUCING DEGRADATION OF PROTEIN IN MAMMALIAN CELL
    Publication number: 20120115232
    Abstract: Provided is a system which can induce the degradation of a protein of interest in a mammalian cell system reliably and stably within a short time. A mammalian cell inducible for protein degradation, the degradation of a protein of interest being induced by an auxin, in which the mammalian cell has both a TIR1 family protein gene from rice and a chimeric gene expressing a protein of interest labeled with a plant Aux/IAA family protein.
    Type: Application
    Filed: November 5, 2009
    Publication date: May 10, 2012
    Applicant: OSAKA UNIVERSITY
    Inventors: Masato Kanemaki, Tatsuo Kakimoto, Kohei Nishimura, Haruhiko Takisawa, Tatsuo Fukagawa