Patents by Inventor Masato Nakafuku

Masato Nakafuku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Numb protein expression inhibitors by Musashi
    Patent number: 7264793
    Abstract: An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide. By the present invention, a new function of Musashi protein has been elucidated. Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.
    Type: Grant
    Filed: November 22, 2001
    Date of Patent: September 4, 2007
    Assignee: Japan Science and Technology Corporation
    Inventors: Takao Imai, Akinori Tokunaga, Tetsu Yoshida, Katsuhiko Mikoshiba, Masato Nakafuku, Hideyuki Okano
  • Numb protein expression inhibitor making use musashi
    Publication number: 20040054140
    Abstract: An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide.
    Type: Application
    Filed: August 21, 2003
    Publication date: March 18, 2004
    Inventors: Takao Imai, Akinori Tokunaga, Tetsu Yoshida, Katsuhiko Mikoshiba, Masato Nakafuku, Hideyuki Okano