Abstract: In a power grid stabilization system, a second energy storage system has a larger energy storage capacity than a first energy storage system. A bidirectional AC/DC converter is connected between an AC power grid and a pair of input and output terminals of the first energy storage system. A first bidirectional DC/DC converter is connected between the pair of input and output terminals of the first energy storage system and a pair of input and output terminals of the second energy storage system.

Abstract: An effective therapeutic agent for subretinal hyperreflective material or retinal diseases accompanying subretinal hyperreflective material is provided by the present invention. Specifically, a therapeutic agent for subretinal hyperreflective material or a retinal disease accompanying subretinal hyperreflective material, containing an aptamer that binds to FGF2 or a salt thereof is provided.

Abstract: Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.

Abstract: The present invention provides an aptamer binding to midkine and capable of forming a potential secondary structure represented by the formula (I): wherein X1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond, X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, and X3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T.

Abstract: The present invention provides an aptamer binding to midkine and capable of forming a potential secondary structure represented by the formula (I): wherein X1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond, X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, and X3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T.

Abstract: The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.

Abstract: The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.

Abstract: Provided is a high-quality aptamer against midkine. An aptamer possessing an inhibitory activity against midkine; a complex comprising an aptamer possessing a binding activity or inhibitory activity against midkine and a functional substance (for example, affinity substances, substances for labeling, enzymes, drug delivery vehicles, drugs and the like); a pharmaceutical drug, cell migration inhibitor, diagnostic reagent, labeling agent and the like comprising an aptamer possessing a binding activity or inhibitory activity against midkine, or a complex comprising the aptamer and a functional substance; a cell migration inhibitor, a diagnostic reagent, a labeling agent and the like.

Abstract: Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.

Abstract: The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.

Abstract: Disclosed is a pipe handle including first and second pipes which are engaged together with a male coupling of the second pipe fitted into a female coupling of the first pipe. The first pipe has a larger inside diameter in the female coupling than in a main body adjacent to the female coupling. The second pipe has a continuous outer surface without any step between the male coupling and a main body adjacent to the male coupling. The main body of the first pipe and the main body of the second pipe has an equal or almost equal outside diameter.

Abstract: The cleaning item of the present invention comprises: a brush part constructed from fibrous material; an inserted part with an inserted space into which a gripper is detachably inserted and which is formed by a pair of sheets, the inserted part being disposed in the brush part; and a joining member which joins the brush part and the inserted part.

Abstract: An indoor cleaning tool having a dry fibrous base material is provided. An antigenicity-reducing composition including an antigenicity-reducing component, an oil and a surfactant are applied to the fibrous base material. Preferably, the antigenicity-reducing component is an extract of an olea or a ligustrum plant extracted with water or an organic solvent.

Abstract: A cleaning implement includes a cleaning head having on a bottom a cleaning operation surface, a holding portion arranged on the side opposite the cleaning head, a pipe for coupling the cleaning head and the holding portion, and a valve opening and closing device provided to the pipe so as to be able to hold a first container for receiving a first fluid or a second container for receiving a second fluid. The holding portion includes a lever coupled to the valve opening and closing device so as to open and close a first valve of the first container or a second valve of the second container. A spout of a second ejection nozzle for ejecting the second fluid containing an allergen inactivator is located, for example, at a height of about 30 cm or more from the floor.

Abstract: A cleaning implement includes a cleaning head having on the bottom a cleaning operation surface and a valve opening and closing device that is connected to the cleaning head and can hold a first container for receiving a first fluid or a second container for receiving a second fluid. The cleaning implement further includes a first circulation path through which the first fluid is ejectable from the cleaning head and a second circulation path through which the second fluid is ejectable by interrupting the first circulation path.

Abstract: A cleaning implement includes a cleaning head having a cleaning operation surface on a bottom, a holding portion arranged on the side opposite the cleaning head, a pipe for coupling the cleaning head and the holding portion, and a valve opening and closing device provided to the pipe so as to be able to hold a first container for receiving a first fluid or a second container for receiving a second fluid. The holding portion includes a lever coupled to the valve opening and closing device so as to open and close a first valve of the first container or a second valve of the second container. A first ejection nozzle can eject the first fluid forward of the cleaning head, and a second ejection nozzle can eject the second fluid rearward of the cleaning head.

Abstract: Disclosed is a cleaning device with a squirter for squirting liquid forward of a cleaning head. The cleaning head has a nozzle head with a nozzle. A liquid receiving part is provided to extend from beneath an orifice of the nozzle toward a front face of the cleaning head. Liquid dripping from the orifice of the nozzle can be led down an inclined top face of the liquid receiving part to the outside of the cleaning head, preventing the cleaning head from being soiled with a detergent, a wax or the like.

Abstract: The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.

Abstract: Provided is a high-quality aptamer against midkine. An aptamer possessing an inhibitory activity against midkine; a complex comprising an aptamer possessing a binding activity or inhibitory activity against midkine and a functional substance (for example, affinity substances, substances for labeling, enzymes, drug delivery vehicles, drugs and the like); a pharmaceutical drug, cell migration inhibitor, diagnostic reagent, labeling agent and the like comprising an aptamer possessing a binding activity or inhibitory activity against midkine, or a complex comprising the aptamer and a functional substance; a cell migration inhibitor, a diagnostic reagent, a labeling agent and the like.

Abstract: There is disclosed a cleaning article including a brush portion. The brush portion has a plurality of strips and at least one layer of a fiber bundle.