Abstract: A novel sustained-release base is provided. The sustained-release base is a combination of a polyvinyl alcohol-based polymer and a low-substituted hydroxypropyl cellulose.

Abstract: A novel binder is provided. The binder comprises a polyvinyl alcohol-based polymer having an average saponification value of 96.0 mol% or more.

Abstract: A novel binder is provided. The binder comprises a polyvinyl alcohol-based polymer which has an average saponification value of 85.0 mol % to 89.0 mol % as measured according to JIS K6726 and meets requirement (A): based on data obtained by measurement of the polyvinyl alcohol-based polymer by liquid chromatography, a value represented by formula (3) shown below is 22 or more, wherein the measurement is performed with a liquid chromatography system equipped with a charged aerosol detector and a Thermo Scientific Acclaim™ 300 column (catalog number: 060266, carbon load: 8%, maximum pressure: 4500 psi, particle size: 3 ?m, pore size: 300 A, stationary phase: C18, surface area: 100 m2/g, length: 150 mm, diameter: 4.6 mm, pH: 2.5 to 7.5, material: glass lined tubing) under the measurement conditions described below, wherein the data represent a baseline-normalized intensity over a retention time of 5.0 to 12.

Abstract: A novel binder is provided. The binder comprises a polyvinyl alcohol-based polymer which has an average saponification value of 85.0 mol % to 89.0 mol % as measured according to JIS K6726 and meets requirement (A): a fluid prepared by adding 130.0 mL of 1-propanol to 100.0 g of a 5.0% by mass aqueous solution of the polyvinyl alcohol-based polymer has a transparency of 80.0% or less at 20° C.; and/or requirement (B): a supernatant from a fluid prepared by adding 230.0 mL of 1-propanol to 100.0 g of a 5.0% by mass aqueous solution of the polyvinyl alcohol-based polymer has a concentration of 0.65% by mass or more at 20° C.

Abstract: Provided are a film coating composition containing a PVA having a degree of hydrolysis of 85.0 to 89.0 mol %, characterized in that even when the composition is used for coating of tablets without any additives other than PVAs, the tablets do not tend to stick to each other; a solid oral formulation using the composition; and a method for producing the same.

Abstract: Provided is a novel coating composition for oral solid preparations. The coating composition for oral solid preparations comprises a polyvinyl alcohol-based polymer (a), a water-swellable clay mineral (b), and a fatty acid ester of a polyol having 3 or more hydroxy groups (c), wherein the polyvinyl alcohol-based polymer (a) and the water-swellable clay mineral (b) are present at a mass ratio of 98:2 to 65:35 in the coating composition.

Abstract: Provided is a novel coating composition for oral solid preparations. The coating composition for oral solid preparations comprises a polyvinyl alcohol-based polymer (a), a fatty acid ester of a polyol having 3 or more hydroxy groups (b), and talc (c), wherein the fatty acid ester of a polyol having 3 or more hydroxy groups (b) has a hydrophilic lipophilic balance (HLB) value of 4.0 or more; wherein the fatty acid ester of a polyol having 3 or more hydroxy groups (b) has 12 to 22 carbon atoms per fatty acid ester unit; and wherein the talc (c) is present at 50% by mass or less of the whole composition.

Abstract: Provided is a method for producing a polyvinyl alcohol resin, comprising the steps of copolymerizing an aliphatic vinyl ester (A) with diacetone acrylamide (B), at least a part of which diacetone acrylamide (B) is added at a later stage, in the presence of a polymerization catalyst in an alcohol solvent, so that the ratio (a)/(b) of the polymerization yield at the end of the polymerization (a) to the polymerization yield at the end of the later addition (b) of diacetone acrylamide (B) is in the range of 1.01 to 1.10, and saponifying the resulting copolymer.

Abstract: Provided are a film coating composition containing a PVA having a degree of hydrolysis of 85.0 to 89.0 mol %, characterized in that even when the composition is used for coating of tablets without any additives other than PVAs, the tablets do not tend to stick to each other; a solid oral formulation using the composition; and a method for producing the same.

Abstract: Provided is a method for producing a polyvinyl alcohol resin, comprising the steps of copolymerizing an aliphatic vinyl ester (A) with diacetone acrylamide (B), at least a part of which diacetone acrylamide (B) is added at a later stage, in the presence of a polymerization catalyst in an alcohol solvent, so that the ratio (a)/(b) of the polymerization yield at the end of the polymerization (a) to the polymerization yield at the end of the later addition (b) of diacetone acrylamide (B) is in the range of 1.01 to 1.10, and saponifying the resulting copolymer.

Abstract: The present invention provides a high molecular weight aliphatic polyester which is biodegradable by microorganisms in soils and which is utilized as a molded article as well as a method to prepare the same. This polyester has a structure shown below: ##STR1## as well as those analogous thereto.