Abstract: The present inventors found that, in the synthesis of a peptide compound involving condensation of a C-terminal-activated substance of an acid component with an amine component, the C-terminal-activated substance can be removed by mixing a solution containing a residual C-terminal-activated substance after a condensation reaction with a tertiary amine and water or an aqueous solution.

Abstract: The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.

Abstract: The present invention provides a novel method for producing a compound represented by general formula (VII) below or a pharmaceutically acceptable salt thereof or a synthetic intermediate thereof: wherein R2 represents a hydrogen atom or a halogen atom, Rc represents a C1-6 alkyl group, X represents a group selected from a heteroaryl group etc., R11 represents an atom or group selected from a hydrogen atom, a halogen atom, a C1-6 alkyl group, etc., R16 and R17 each independently represent an atom or group selected from a hydrogen atom, a C1-6 alkyl group, etc., and R15 represents a hydrogen atom or a C1-6 alkyl group.

Abstract: The present invention provides a novel method for producing a compound represented by general formula (VII) below or a pharmaceutically acceptable salt thereof or a synthetic intermediate thereof: wherein R2 represents a hydrogen atom or a halogen atom, Rc represents a C1-6 alkyl group, X represents a group selected from a heteroaryl group etc., R11 represents an atom or group selected from a hydrogen atom, a halogen atom, a C1-6 alkyl group, etc., R16 and R17 each independently represent an atom or group selected from a hydrogen atom, a C1-6 alkyl group, etc., and R15 represents a hydrogen atom or a C1-6 alkyl group.

Abstract: The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.

Abstract: The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.

Abstract: The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.

Abstract: The present invention relates to a compound having the formula below which have an excellent cardiotonic action: ##STR1## wherein Y represents C.sub.1-4 alkylene which may be substituted by C.sub.1-18 alkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio C.sub.1-5 alkyl, C.sub.1-5 alkoxycarbonyl or benzyl, or ##STR2## where each r.sup.1 and r.sup.2 represents hydrogen, C.sub.1-18 alkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio C.sub.1-5 alkyl, C.sub.1-5 alkoxycarbonyl or benzyl); andR.sub.1 represents hydrogen, C.sub.1-5 alkyl which may be substituted by C.sub.1-5 alkoxy, acetyl or C.sub.2-5 alkenyl; andR.sub.2 represents hydrogen or methyl; andeach R.sub.3 and R.sub.4 represents hydrogen, halogen, hydroxy, C.sub.1-5 alkyl, or C.sub.1-5 alkoxy; andR.sub.5 represents hydrogen or C.sub.1-5 alkyl which may be substituted by hydroxy; andR.sub.4 and R.sub.5 may form ring by joining each other; and represents single or double bond.