Patents by Inventor Masatoshi Tsujino

Masatoshi Tsujino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel nucleoside-phospholipid conjugate
    Patent number: 5051499
    Abstract: Novel nucleoside-phospholipid conjugates of the formula ##STR1## wherein R.sub.1 is C.sub.14-24 long chain aliphatic acyl or C.sub.1-24 aliphatic alkyl, R.sub.2 is C.sub.2-10 aliphatic acyl or C.sub.1-24 aliphatic alkyl and N.sub.s is a nucleoside residue; and pharmacologically acceptable salts thereof are prepared in a one-step reaction by reacting the corresponding nucleoside and glycerophospholipid derivative in the presence of phospholipase D-P.
    Type: Grant
    Filed: November 28, 1989
    Date of Patent: September 24, 1991
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Satoshi Shuto, Hiromichi Itoh, Kiyofumi Fukukawa, Masatoshi Tsujino
  • Nucleoside-phospholipid conjugate
    Patent number: 4921951
    Abstract: Novel nucleoside-phospholipid conjugates of the formula ##STR1## wherein R.sub.1 is C.sub.14-24 long chain aliphatic acyl or C.sub.1-24 aliphatic alkyl and N.sub.s is a nucleoside residue; and pharmacologically acceptable salts thereof are prepared in a one-step reaction by reacting the corresponding nucleoside and glycerophospholipid derivative in the presence of phospholipase D-P.
    Type: Grant
    Filed: September 28, 1987
    Date of Patent: May 1, 1990
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Satoshi Shuto, Hiromichi Itoh, Kiyofumi Fukukawa, Masatoshi Tsujino
  • 2'-(R)-substituted-2'-deoxyneplanocin A derivatives
    Patent number: 4816575
    Abstract: Neplanocin A derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen or benzoyl, R.sub.4 is hydrogen or halogen, hydroxy, acetoxy, acetylthio, amino or azide, R.sub.5 is hydrogen or acetyl, and R.sub.6 is hydrogen or acetyl. The compounds of the present invention have inhibitory action for the growth of L 5178 Y cells and have the same or superior activity as neplanocin A.
    Type: Grant
    Filed: June 24, 1986
    Date of Patent: March 28, 1989
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Kiyofumi Fukukawa, Takao Hirano, Masatoshi Tsujino, Tooru Ueda
  • Nucleoside-phospholipid conjugate
    Patent number: 4797479
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are long-chain fatty acid residue, and Ns is nucleoside residue selected from the group consisting of 5-fluorouridine-5'-yl, 5-fluoro-2'-deoxyuridine-5'-yl-, bredinin-5'-yl, tubercidine-5'-yl-, neplanocin A-6'-yl-, 5-fluorocytidine-5'-yl-, arabinosylcytosine-5'-yl, arabinocyl-5-fluorocytosine-5'-yl-, arabinosyladenine-5'-yl- and arabinosylthymine-5 '-yl-, and pharmacologically acceptable salts thereof, having antitumor activity.
    Type: Grant
    Filed: April 15, 1986
    Date of Patent: January 10, 1989
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Satoshi Shuto, Hiromichi Ito, Kiyofumi Fukukawa, Hideo Sakakibara, Masatoshi Tsujino
  • Neplanocin A derivatives
    Patent number: 4613666
    Abstract: Neplanocin A derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or benzoyl, R.sub.3 is hydrogen or OR.sub.8, R.sub.5 is hydrogen or acetyl, R.sub.6 is hydrogen, acetyl or benzoyl, when R.sub.3 is hydrogen, R.sub.4 is hydrogen or halogen, hydroxy, acetoxy, acetylthio, amino or azide, and when R.sub.3 is OR.sub.8, R.sub.4 is hydrogen, R.sub.8 is hydrogen or acetyl, or R.sub.8 and R.sub.5 together form benzylidene, and at least one of R.sub.8, R.sub.5 and R.sub.6 is other than hydrogen. The compounds of the present invention have inhibitory action for the growth of L 5178 Y cells and have the same or superior activity as neplanocin A, and hence are useful as antitumor agents.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: September 23, 1986
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Kiyofumi Fukukawa, Takao Hirano, Masatoshi Tsujino, Tooru Ueda, Tadashiro Fujii, Satoshi Yaginuma
  • Antibiotic neplanocin A
    Patent number: 4423218
    Abstract: Antibiotic neplanocin A of the formula ##STR1## is produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin A thus produced from the culture medium.
    Type: Grant
    Filed: November 3, 1980
    Date of Patent: December 27, 1983
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Masaru Otani, Satoshi Yaginuma, Masatoshi Tsujino, Naoki Muto, Tetsu Saito, Tadashiro Fujii
  • Neplanocin-B and -F
    Patent number: 4321376
    Abstract: Neplanocin-B and -F of the formula ##STR1## in which Y is oxygen or a valence bond, are produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin-B and -F thus produced from the culture medium.
    Type: Grant
    Filed: December 7, 1979
    Date of Patent: March 23, 1982
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Masaru Otani, Satoshi Yaginuma, Masatoshi Tsujino, Naoki Muto, Tetsu Saito, Tadashiro Fujii