Patents by Inventor Masatsugu Hori
Masatsugu Hori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9095600Abstract: The present invention relates to a novel preventive and/or therapeutic drug for myocardial infarction. The present invention provides a preventive and/or therapeutic drug for myocardial infarction or myocardial ischemia-reperfusion injury, the drug containing a lipid membrane structure retaining adenosine.Type: GrantFiled: September 18, 2009Date of Patent: August 4, 2015Assignees: OSAKA UNIVERSITY, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, DAIICHI SANKYO COMPANY, LIMITEDInventors: Tetsuo Minamino, Masafumi Kitakaze, Masatsugu Hori, Hiroyuki Takahama, Hiroshi Kikuchi, Kouichi Hashimoto, Hideo Kobayashi, Ayako Iijima, Daigo Asano
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Publication number: 20140051074Abstract: An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and the advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging an inflammatory disease which comprises detecting at least 1 type of genetic polymorphism existing in at least one gene selected from the group consisting of the LBP-32 gene, the TSBP gene, and the WAP gene.Type: ApplicationFiled: July 30, 2013Publication date: February 20, 2014Applicant: RIKENInventors: Toshihiro TANAKA, Yusuke NAKAMURA, Yozo OHNISHI, Kouichi OZAKI, Aritoshi IIDA, Masatsugu HORI
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Patent number: 8518644Abstract: An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and the advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging an inflammatory disease which comprises detecting at least 1 type of genetic polymorphism existing in at least one gene selected from the group consisting of the LBP-32 gene, the TSBP gene, and the WAP gene.Type: GrantFiled: July 6, 2006Date of Patent: August 27, 2013Assignee: RikenInventors: Toshihiro Tanaka, Yusuke Nakamura, Yozo Ohnishi, Koichi Ozaki, Aritoshi Iida, Masatsugu Hori
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Patent number: 8158351Abstract: It is an object of the present invention to provide a method for determining inflammatory diseases including myocardial infarction as a typical example, which involves identifying polymorphisms associated with myocardial infarction and using the gene polymorphisms, an oligonucleotide that can be used for the method, a kit for diagnosing inflammatory diseases, a therapeutic agent for inflammatory diseases, and the like. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one type of gene polymorphism existing in a proteasome subunit ? type 6 gene.Type: GrantFiled: June 15, 2007Date of Patent: April 17, 2012Assignee: RikenInventors: Toshihiro Tanaka, Yusuke Nakamura, Aritoshi Iida, Kouichi Ozaki, Masatsugu Hori
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Patent number: 8048625Abstract: A single nucleotide polymorphism occurring on a leptin receptor gene is analyzed and an inflammatory disease is examined on the basis of the analytical data. Further, a substance capable of changing the interaction between the leptin receptor and galectin-2 is selected to thereby screen a remedy for an inflammatory disease.Type: GrantFiled: December 22, 2005Date of Patent: November 1, 2011Assignee: RikenInventors: Toshihiro Tanaka, Koichi Ozaki, Aritoshi Iida, Masatsugu Hori, Yozo Ohnishi, Yusuke Nakamura
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Patent number: 8026063Abstract: A gene polymorphism on a Toll-like receptor gene is analyzed and an inflammatory disease is examined based on the results of the analysis. A remedy for an inflammatory disease is screened by selecting a substance capable of altering the interaction between Toll-like receptor and galectin-2.Type: GrantFiled: January 11, 2006Date of Patent: September 27, 2011Assignee: RikenInventors: Toshihiro Tanaka, Koichi Ozaki, Aritoshi Iida, Masatsugu Hori, Yusuke Nakamura
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Publication number: 20110097711Abstract: An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and the advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging an inflammatory disease which comprises detecting at least 1 type of genetic polymorphism existing in at least one gene selected from the group consisting of the LBP-32 gene, the TSBP gene, and the WAP gene.Type: ApplicationFiled: January 6, 2006Publication date: April 28, 2011Applicant: RIKENInventors: Toshihiro Tanaka, Yusuke Nakamura, Yozo Ohnishi, Koichi Ozaki, Aritoshi Iida, Masatsugu Hori
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Publication number: 20100323346Abstract: A single nucleotide polymorphism occurring on a leptin receptor gene is analyzed and an inflammatory disease is examined on the basis of the analytical data. Further, a substance capable of changing the interaction between the leptin receptor and galectin-2 is selected to thereby screen a remedy for an inflammatory disease.Type: ApplicationFiled: December 22, 2005Publication date: December 23, 2010Applicant: RIKENInventors: Toshihisa Tanaka, Koichi Ozaki, Aritoshi Iida, Masatsugu Hori, Yozo Ohnishi, Yusuke Nakamura
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Publication number: 20100233684Abstract: It is an object of the present invention to provide a method for determining inflammatory diseases including myocardial infarction as a typical example, which involves identifying polymorphisms associated with myocardial infarction and using the gene polymorphisms, an oligonucleotide that can be used for the method, a kit for diagnosing inflammatory diseases, a therapeutic agent for inflammatory diseases, and the like. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one type of gene polymorphism existing in a proteasome subunit ? type 6 gene.Type: ApplicationFiled: June 15, 2007Publication date: September 16, 2010Applicant: RIKENInventors: Toshihiro Tanaka, Yusuke Nakamura, Aritoshi Iida, Kouichi Ozaki, Masatsugu Hori
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Patent number: 7754422Abstract: The object of the present invention is to determine inflammatory diseases such as myocardial infarction by identifying single nucleotide polymorphisms (SNPs) associated with myocardial infarction and utilizing these SNPs. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one gene polymorphism existing in at least one gene selected from the group consisting of a lymphotoxin-? (LT-?) gene, an I Kappa B-like (IKBL) gene, and a BAT1 gene; an oligonucleotide used in said method; a kit for diagnosing an inflammatory disease which comprises said oligonucleotide; and use thereof. The present invention further provides a method for treating an inflammatory disease; and a method for screening for a therapeutic agent for an inflammatory disease.Type: GrantFiled: August 8, 2003Date of Patent: July 13, 2010Assignee: RikenInventors: Toshihiro Tanaka, Yozo Ohnishi, Koichi Ozaki, Aritoshi Iida, Yusuke Nakamura, Masatsugu Hori
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Publication number: 20100098753Abstract: The present invention relates to a novel preventive and/or therapeutic drug for myocardial infarction. The present invention provides a preventive and/or therapeutic drug for myocardial infarction or myocardial ischemia-reperfusion injury, the drug containing a lipid membrane structure retaining adenosine.Type: ApplicationFiled: September 18, 2009Publication date: April 22, 2010Applicants: Osaka University, JAPAN AS REP. BY THE PRES. OF NAT'L. CARDIO. CENTR, DAIICHI SANKYO COMPANY, LIMITEDInventors: Tetsuo MINAMINO, Masafumi Kitakaze, Masatsugu Hori, Hiroyuki Takahama, Hiroshi Kikuchi, Kouichi Hashimoto, Hideo Kobayashi, Ayako IIJIMA, Daigo Asano
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Publication number: 20080280293Abstract: A gene polymorphism on a Toll-like receptor gene is analyzed and an inflammatory disease is examined based on the results of the analysis. A remedy for an inflammatory disease is screened by selecting a substance capable of altering the interaction between Toll-like receptor and galectin-2.Type: ApplicationFiled: January 11, 2006Publication date: November 13, 2008Applicant: RikenInventors: Toshihiro Tanaka, Koichi Ozaki, Aritoshi Iida, Masatsugu Hori, Yusuke Nakamura
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Publication number: 20070190528Abstract: An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and development of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging inflammatory diseases which comprises detecting at least one gene polymorphism in the galectin-2 gene.Type: ApplicationFiled: August 18, 2004Publication date: August 16, 2007Applicants: RIKENInventors: Toshihiro Tanaka, Yozo Ohnishi, Kouichi Ozaki, Aritoshi Iida, Masatsugu Hori, Yusuke Nakamura
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Publication number: 20070065850Abstract: A method for diagnosis of heart failure in a human subject, which comprises the step of: measuring an endoplasmic reticulum (ER)-initiated apoptotic signal such as CHOP in a biological sample originated from the subject is disclosed. According to the invention, by employing the new marker in stead of or in addition to a conventional cardiac marker such as BNP, more accurate diagnosis of heart failure can be attained.Type: ApplicationFiled: August 10, 2006Publication date: March 22, 2007Inventors: Tetuo Minamino, Masatsugu Hori, Ken-ichiro Okada, Masafumi Kitakaze
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Publication number: 20060147920Abstract: The object of the present invention is to determine inflammatory diseases such as myocardial infarction by identifying single nucleotide polymorphisms (SNPs) associated with myocardial infarction and utilizing these SNPs. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one gene polymorphism existing in at least one gene selected from the group consisting of a lymphotoxin-? (LT-?) gene, an I Kappa B-like (IKBL) gene, and a BAT1 gene; an oligonucleotide used in said method; a kit for diagnosing an inflammatory disease which comprises said oligonucleotide; and use thereof. The present invention further provides a method for treating an inflammatory disease; and a method for screening for a therapeutic agent for an inflammatory disease.Type: ApplicationFiled: August 8, 2003Publication date: July 6, 2006Inventors: Toshihiro Tanaka, Yozo Ohnishi, Koichi Ozaki, Aritoshi Iida, Yusuke Nakamura, Masatsugu Hori
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Patent number: 5571524Abstract: An agent for curing ischemic myocardial disease which contains an effective amount of diadenosine 5',5'"-p.sup.1,p.sup.4 -tetraphosphate (Ap4A) of formula (I): ##STR1## or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: June 6, 1995Date of Patent: November 5, 1996Assignees: Unitika Ltd., Fujirebio, Inc.Inventors: Masafumi Kitakaze, Masatsugu Hori, Takenobu Kamada, Hiroshi Nakajima, Akihiro Sekine, Tetsuaki Yamaura