Patents by Inventor Masatsugu Ozasa

Masatsugu Ozasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220170841
    Abstract: A detection method according to one or more embodiments may include transporting a rack holding a reaction vessel along a first axis toward a sample dispensing position, linearly moving the sample dispensing pipette above the rack along a second axis intersecting the first axis and dispensing a sample into the reaction vessel located at the sample dispensing position, transporting the rack along the first axis toward a reagent dispensing position; linearly moving a reagent dispensing pipette above the rack along a third axis intersecting the first axis, and dispensing a reagent into the reaction vessel located at the reagent dispensing position, and detecting a detection target in a measurement specimen prepared from the sample and the reagent.
    Type: Application
    Filed: November 29, 2021
    Publication date: June 2, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Masatsugu OZASA, Daiki FUJIWARA, Daiki MITA, Takaaki OKAJIMA, Hideki HIRAYAMA
  • Patent number: 10309877
    Abstract: Disclosed is a method for analyzing atypical cells in urine including: mixing urine, a diluent containing a surfactant, and a nucleic acid staining reagent to prepare a measurement specimen; irradiating the measurement specimen with light to detect scattered light and fluorescence light emitted from cells whose nucleic acids are stained; and detecting atypical cells contained in the measurement specimen distinguishably from white blood cells depending on a first characteristic parameter based on the scattered light and a second characteristic parameter based on the fluorescence light.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: June 4, 2019
    Assignee: Sysmex Corporation
    Inventors: Shota Tateyama, Masanori Kawano, Masatsugu Ozasa
  • Patent number: 9835559
    Abstract: A urine specimen analysis device includes a specimen drawing portion, a sample preparing portion, a measurement portion, and an information processing portion. The specimen drawing portion draws a first aliquot and a second aliquot from a urine specimen. The sample preparing portion prepares a first measurement sample by mixing the first aliquot and a first staining dye that stains red blood cells, and a second measurement sample by mixing the second aliquot and a second staining dye that stains nucleic acids. The measurement portion measures fluorescence emitted from the first measurement sample prepared by the sample preparing portion, and fluorescence emitted from the second measurement sample prepared by the sample preparing portion.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: December 5, 2017
    Assignee: Sysmex Corporation
    Inventors: Masatsugu Ozasa, Kanako Nagaoka, Akinori Kawai, Masanori Kawano
  • Patent number: 9719123
    Abstract: Disclosed is a urine sample analyzer for analyzing particles contained in a urine sample and outputting analytical results. The analyzer includes a flow cell that accepts a measurement specimen, the measurement specimen comprising a urine sample mixed with a reagent, a light irradiation unit positioned to irradiate the flowing measurement specimen with light, a light detector that detects light from individual particles in the flowing measurement specimen, and a data processor that receives signal from the light detector, processes the signal to obtain parameter information corresponding to a length of a cell cluster, and classifies fungi in the measurement specimen into groups by using the parameter information.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: August 1, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Shota Tateyama, Masanori Kawano, Masatsugu Ozasa
  • Patent number: 9664669
    Abstract: Disclosed is a urine specimen analyzing method which improves the detection of casts in a urine specimen by flowing a measurement sample containing a urine specimen through a flow cell, irradiating light on the measurement sample flowing through the flow cell, generating a signal waveform indicating a temporal change of intensity of light given off by the measurement sample, and detecting casts distinguishably from mucus threads contained in the urine specimen, based on information related to respective slope at both end sides of the signal waveform corresponding to each formed element contained in the urine specimen.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: May 30, 2017
    Assignee: Sysmex Corporation
    Inventors: Masatsugu Ozasa, Keisuke Tsutsumida, Kenji Hanamura, Kunio Ueno
  • Patent number: 9551657
    Abstract: Disclosed is a sample analyzer which comprises: a sample preparing section configured to prepare a measurement sample by mixing a sample and a nucleic acid staining reagent; an optical detector configured to irradiate light on cells contained in the measurement sample, receive fluorescent light given off by the irradiated cells, and output fluorescent light signals; a signal processing section which obtains fluorescent light intensity and fluorescence pulse area of the cells from the fluorescent light signals output by the optical detector; and an information processing section configured to detect white blood cells contained in the measurement sample based on the fluorescence pulse area, and detect bacteria contained in the measurement sample based on the fluorescent light intensity.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: January 24, 2017
    Assignee: Sysmex Corporation
    Inventors: Masatsugu Ozasa, Mitsumasa Sakamoto, Masanori Kawano
  • Patent number: 9417231
    Abstract: Disclosed is a urine sample analyzing method comprising: flowing a measurement specimen prepared by mixing a urine sample and reagent through a flow cell; irradiating epithelial cells in the measurement specimen flowing through the flow cell with linearly polarized light and thereby producing scattered light; detecting a change of polarization condition of the scattered light produced by each of the epithelial cells; and classifying the epithelial cells into at least two types based on the change of polarization condition.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: August 16, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Mitsumasa Sakamoto, Masatsugu Ozasa
  • Patent number: 9354161
    Abstract: Disclosed is a sample analyzing method comprising: flowing a measurement specimen prepared by mixing a sample and reagent through a flow cell; irradiating particles in the measurement specimen flowing through the flow cell with linearly polarized light and thereby producing scattered light; detecting a change of polarization condition of the scattered light produced by the particles; and discriminating erythrocytes from crystals in the measurement specimen based on the change of polarization condition.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: May 31, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Mitsumasa Sakamoto, Masatsugu Ozasa
  • Patent number: 9329133
    Abstract: An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: May 3, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Yousuke Tanaka, Junya Inoue, Masatsugu Ozasa, Yasuyuki Kawashima
  • Publication number: 20160054222
    Abstract: Disclosed is a method for analyzing atypical cells in urine including: mixing urine, a diluent containing a surfactant, and a nucleic acid staining reagent to prepare a measurement specimen; irradiating the measurement specimen with light to detect scattered light and fluorescence light emitted from cells whose nucleic acids are stained; and detecting atypical cells contained in the measurement specimen distinguishably from white blood cells depending on a first characteristic parameter based on the scattered light and a second characteristic parameter based on the fluorescence light.
    Type: Application
    Filed: August 20, 2015
    Publication date: February 25, 2016
    Inventors: Shota TATEYAMA, Masanori KAWANO, Masatsugu OZASA
  • Publication number: 20150369741
    Abstract: A urine specimen analysis device includes a specimen drawing portion, a sample preparing portion, a measurement portion, and an information processing portion. The specimen drawing portion draws a first aliquot and a second aliquot from a urine specimen. The sample preparing portion prepares a first measurement sample by mixing the first aliquot and a first staining dye that stains red blood cells, and a second measurement sample by mixing the second aliquot and a second staining dye that stains nucleic acids. The measurement portion measures fluorescence emitted from the first measurement sample prepared by the sample preparing portion, and fluorescence emitted from the second measurement sample prepared by the sample preparing portion.
    Type: Application
    Filed: August 27, 2015
    Publication date: December 24, 2015
    Inventors: Masatsugu OZASA, Kanako NAGAOKA, Akinori KAWAI, Masanori KAWANO
  • Publication number: 20150276592
    Abstract: Disclosed is a urine specimen analyzing method which improves the detection of casts in a urine specimen by flowing a measurement sample containing a urine specimen through a flow cell, irradiating light on the measurement sample flowing through the flow cell, generating a signal waveform indicating a temporal change of intensity of light given off by the measurement sample, and detecting casts distinguishably from mucus threads contained in the urine specimen, based on information related to respective slope at both end sides of the signal waveform corresponding to each formed element contained in the urine specimen.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 1, 2015
    Inventors: Masatsugu OZASA, Keisuke TSUTSUMIDA, Kenji HANAMURA, Kunio UENO
  • Publication number: 20150247802
    Abstract: Disclosed is a sample analyzer which comprises: a sample preparing section configured to prepare a measurement sample by mixing a sample and a nucleic acid staining reagent; an optical detector configured to irradiate light on cells contained in the measurement sample, receive fluorescent light given off by the irradiated cells, and output fluorescent light signals; a signal processing section which obtains fluorescent light intensity and fluorescence pulse area of the cells from the fluorescent light signals output by the optical detector; and an information processing section configured to detect white blood cells contained in the measurement sample based on the fluorescence pulse area, and detect bacteria contained in the measurement sample based on the fluorescent light intensity.
    Type: Application
    Filed: February 27, 2015
    Publication date: September 3, 2015
    Inventors: Masatsugu OZASA, Mitsumasa SAKAMOTO, Masanori KAWANO
  • Publication number: 20150118706
    Abstract: Disclosed is a urine sample analyzer for analyzing particles contained in a urine sample and outputting analytical results. The analyzer includes a flow cell that accepts a measurement specimen, the measurement specimen comprising a urine sample mixed with a reagent, a light irradiation unit positioned to irradiate the flowing measurement specimen with light, a light detector that detects light from individual particles in the flowing measurement specimen, and a data processor that receives signal from the light detector, processes the signal to obtain parameter information corresponding to a length of a cell cluster, and classifies fungi in the measurement specimen into groups by using the parameter information.
    Type: Application
    Filed: October 27, 2014
    Publication date: April 30, 2015
    Inventors: Shota TATEYAMA, Masanori KAWANO, Masatsugu OZASA
  • Publication number: 20150060647
    Abstract: Disclosed is a urine sample analyzing method comprising: flowing a measurement specimen prepared by mixing a urine sample and reagent through a flow cell; irradiating epithelial cells in the measurement specimen flowing through the flow cell with linearly polarized light and thereby producing scattered light; detecting a change of polarization condition of the scattered light produced by each of the epithelial cells; and classifying the epithelial cells into at least two types based on the change of polarization condition.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 5, 2015
    Inventors: Mitsumasa SAKAMOTO, Masatsugu OZASA
  • Publication number: 20150064742
    Abstract: Disclosed is a sample analyzing method comprising: flowing a measurement specimen prepared by mixing a sample and reagent through a flow cell; irradiating particles in the measurement specimen flowing through the flow cell with linearly polarized light and thereby producing scattered light; detecting a change of polarization condition of the scattered light produced by the particles; and discriminating erythrocytes from crystals in the measurement specimen based on the change of polarization condition.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 5, 2015
    Inventors: Mitsumasa SAKAMOTO, Masatsugu OZASA
  • Patent number: 8772738
    Abstract: A particle analyzing apparatus, comprising: a flow cell which forms a specimen flow including particles; first and second light sources; an irradiation optical system which applies lights emitted from the first and second light sources so that the lights are applied to the specimen flow; a detector which detects forward scattered light, the forward scattered light being emitted from the first light and scattered by the particle in the specimen flow, and generates a signal according to the detected scattered light; a light blocking member disposed between the flow cell and the detector; a controller which obtains characteristic parameters of the particle based on the signal from the detector; and an imaging device which captures an image of the particle in the specimen flow using the light from the second light source is disclosed. Particle imaging method is also disclosed.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: July 8, 2014
    Assignee: Sysmex Corporation
    Inventors: Masatsugu Ozasa, Hiroyuki Kobayashi
  • Patent number: 8675196
    Abstract: An analyzer comprises: a sample stream forming section for forming a sample stream including particles; a light source; an optical fiber bundle formed by a plurality of optical fibers, into which light from the light source enters, and which emits light onto the sample stream; and an imaging device for imaging a particle in the irradiated sample stream.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: March 18, 2014
    Assignee: Sysmex Corporation
    Inventor: Masatsugu Ozasa
  • Publication number: 20130316444
    Abstract: An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.
    Type: Application
    Filed: August 5, 2013
    Publication date: November 28, 2013
    Applicant: SYSMEX CORPORATION
    Inventors: Yousuke TANAKA, Junya Inoue, Masatsugu Ozasa, Yasuyuki Kawashima
  • Patent number: 8501482
    Abstract: An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: August 6, 2013
    Assignee: Sysmex Corporation
    Inventors: Yousuke Tanaka, Junya Inoue, Masatsugu Ozasa, Yasuyuki Kawashima