Abstract: A compound of formula (I) or a salt thereof, and medical use thereof (the symbols in the formula are as described in the specification). The compound of formula (I) has CCR4 antagonistic activity, and therefore is useful as a preventive and/or therapeutic agent for diseases associated with CCR4, i.e., CCR4-mediated diseases such as inflammatory and/or allergic diseases [e.g., systemic inflammatory response syndrome (SIRS), anaphylaxis or anaphylaxis-like reaction, allergic vasculitis, reject reaction for graft organ, hepatitis, nephritis, nephrosis, pancreatitis, rhinitis, arthritis, inflammatory ocular diseases, inflammatory bowel diseases, diseases in cerebro and/or circulatory system, respiratory diseases, dermatic diseases, autoimmune diseases, etc.], and the like.

Abstract: A nonvolatile semiconductor memory device has a plurality of word lines, a plurality of bit lines, a plurality of nonvolatile memory cells, and a source power supply circuit. Each of the nonvolatile memory cells is formed of a MIS transistor disposed at each intersection of the word lines and the bit lines, and a threshold voltage of the MIS transistor is externally electrically controllable. The source power supply circuit, which is connected to sources of the nonvolatile memory cells, is used to apply a first voltage to the sources of the nonvolatile memory cells to negate an influence caused by an over-erase phenomenon at the time of a reading operation.