Patents by Inventor Masayasu Inoue

Masayasu Inoue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5414089
    Abstract: Provided is a long chain carboxylic acid imide ester (I) represented by the following general formula (I) ##STR1## wherein W is a divalent long chain hydrocarbon group which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom, and a group of --N(R.sup.1)-- (R.sup.1 being a lower alkyl group) and X represents a divalent hydrocarbon group which may optionally be substituted, or salts thereof. The above long chain carboxylic acid imide ester or its salts is useful for modifying enzymes or proteins having biological activities to give their derivatives which have, while retaining most of the original biological activities, an extremely prolonged plasma half-life as compared with the proteins and have no antigenecities and can be administered to animals.
    Type: Grant
    Filed: August 16, 1993
    Date of Patent: May 9, 1995
    Assignee: Kuraray Co., Ltd.
    Inventors: Iwao Ebashi, Tetsuo Takigawa, Masayasu Inoue
  • Patent number: 5360914
    Abstract: Provided are novel superoxide dismutase derivatives represented by the following general formula (I) ##STR1## wherein [SOD] is a superoxide dismutase residue derived by removal of two mercapto groups, and W is a divalent long chain hydrocarbon residue which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of -N(R)- (R being a lower alkyl group). The SOD derivatives retain most of the enzymatic activities of unmodified SOD and have much longer plasma half-life than unmodified SOD. They are effective for treating various diseases caused by active oxygen species.Also provided are chemical modifiers to prepare the above SOD derivatives.
    Type: Grant
    Filed: May 11, 1993
    Date of Patent: November 1, 1994
    Assignees: Kuraray Co., Ltd., Masayasu Inoue
    Inventors: Masayasu Inoue, Iwao Ebashi, Tetsuo Takigawa
  • Patent number: 5336782
    Abstract: Provided is a long chain carboxylic acid imide ester (I) represented by the following general formula (I) ##STR1## wherein W is a divalent long chain hydrocarbon group which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of --N(R.sup.1)-- (R.sup.1 being a lower alkyl group) and X represents a divalent hydrocarbon group which may optionally be substituted, or salts thereof. The above long chain carboxylic acid imide ester or its salts is useful for modifying enzymes or proteins having biological activities to give their derivatives which have, while retaining most of the original biological activities, an extremely prolonged plasma half-life as compared with the proteins and have no antigenecities and can be administered to animals.
    Type: Grant
    Filed: April 23, 1992
    Date of Patent: August 9, 1994
    Assignee: Kuraray Co., Ltd.
    Inventors: Iwao Ebashi, Tetsuo Takigawa, Masayasu Inoue
  • Patent number: 5238837
    Abstract: Provided are novel superoxide dismutase derivatives represented by the following general formula (I) ##STR1## wherein [SOD] is a superoxide dismutase residue derived by removal of two mercapto groups, and W is a divalent long chain hydrocarbon residue which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of --N(R)-- (R being a lower alkyl group). The SOD derivatives retain most of the enzymatic activities of unmodified SOD and have much longer plasma half-life than unmodified SOD. They are effective for treating various diseases caused by active oxygen species.Also provided are chemical modifiers to prepare the above SOD derivatives.
    Type: Grant
    Filed: December 6, 1991
    Date of Patent: August 24, 1993
    Assignees: Kuraray Co., Ltd., Masayasu Inoue
    Inventors: Masayasu Inoue, Iwao Ebashi, Tetsuo Takigawa
  • Patent number: 4968616
    Abstract: Novel superoxide dismutase derivatives are provided in which the enzymatic activity of superoxide dismutase capable of decomposing superoxide, a substance harmful to living organisms, is for the most part maintained with the plasma half-life being significantly prolonged as compared with superoxide dismutase itself. They have pharmacological activities such as anti-inflammatory, anti-ischemic and cerebral edema-preventing activities. Also provided are a method of producing such superoxide dismutase derivatives and medicinal uses of them.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: November 6, 1990
    Assignees: Masayasu Inoue, Kuraray Co., Ltd.
    Inventors: Masayasu Inoue, Tetsuya Ogino, Yoshimasa Morino, Masahiko Hirota
  • Patent number: 4968495
    Abstract: A bilirubin oxidase derivative resulting from chemical modification of a water-soluble polymeric substance. The chemically modified bilirubin oxidase is useful as a drug for treating jaundice.
    Type: Grant
    Filed: July 29, 1988
    Date of Patent: November 6, 1990
    Assignee: Amano Pharmaceutical Co., Ltd.
    Inventors: Masayasu Inoue, Hiroshi Maeda
  • Patent number: RE36359
    Abstract: Provided is a long chain carboxylic acid imide ester (I) represented by the following general formula (I) ##STR1## wherein W is a divalent long chain hydrocarbon group which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen, atom, a sulfur atom, and a group of --N(R.sup.1)-- (R.sup.1 being a lower alkyl group) and X represents a divalent hydrocarbon group which may optionally be substituted, or salt thereof. The above long chain carboxylic acid imide ester or its salts is useful for modifying enzymes or proteins having biological activities to give their derivatives which have, while retaining most of the original biological activities, an extremely prolonged plasma half-life as compared with the proteins and have no antigenecities and can be administered to animals.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: October 26, 1999
    Assignee: Kuraray Co., Ltd.
    Inventors: Iwao Ebashi, Tetsuo Takigawa, Masayasu Inoue