Abstract: An object to be achieved by the present invention is to provide a method for determining the amount of a component contained in a specific lipoprotein fraction in a biological sample using an automatic analyzer, without the requirement of a step of fractionating a sample by centrifugation. The present invention provides a method for separating a target component in a biological sample, which comprises the steps of: (1) causing a biological sample to come into contact with independently dispersed magnetic nanoparticles having a particle size of 50 nm or less, which have anionic functional groups on their surfaces, so as to form an agglutinate of the magnetic nanoparticles and biomolecules capable of interacting with the magnetic nanoparticles; and (2) collecting the agglutinate by an external magnetic field.

Abstract: A fastener element for a concealed type slide fastener having a substantially U shaped section including a side edge portion mounting groove for a fastener tape, comprising: a C shaped base portion; flat first and second tape nipping portions extended substantially in parallel from respective front ends of the C shaped base portion; and a coupling portion integrated with an engaging face side on the opposite side to a tape nipping face of the second tape nipping portion, wherein the first tape nipping portion has expanded portions expanded back and forth in a coupling direction, and a front end face of the first tape nipping portion is formed wider than a front end face of the second tape nipping portion, thereby having excellent concealed property and coupling strength and capable of preventing generation of a gap between right and left fastener tapes even if pulling stress is applied.

Abstract: A magnetic composite body comprising magnetic nanoparticles having a number average particle diameter of 1 to 50 nm and having a compound represented by formula (I) fixed on their surfaces, and a method comprising bringing the magnetic composite body into contact with a test piece followed by magnetic separation: R1O—(CH(R2)CH2O)n-L-X ??Formula (I) wherein R1 represents a hydrogen atom, an alkyl or alkenyl group having a carbon chain length of 1 to 20, or a substituted or unsubstituted, aryl or heterocyclic group; R2 represents a hydrogen atom or a methyl group; L may be present or not present, and, when L is present, L represents an alkylene or alkenylene group having a carbon chain length of 1 to 10 which may have a branched chain or a substituent; X represents a hydrogen atom, a carboxylic acid group, a phosphoric acid group, or a sulfonic acid group; and n represents an integer of 1 to 10

Abstract: A slider for a concealed type slide fastener for securing a smooth sliding operation even if a strong laterally pulling force is applied when the slide fastener is closed. The slider includes: a lower plate having a pair of flanges each having an inverted L shaped section, the flanges erected along right and left side edges perpendicular to a sliding direction of the slider; a diamond erected toward a gap between upper plate portions of the pair of flanges from a central portion of the lower plate; and element guide portions expanded outwardly toward inside end faces of the upper plate portions from an outer periphery of the diamond, wherein the front ends of the upper plate portion in an engagement direction of the fastener elements are extended forward compared with front end of the element guide portion.

Abstract: Two or more target substances are simply and efficiently detected using one type of nanoparticle. Two or more target substances contained in one sample are labeled with two or more fluorescent dyes each capable of binding to the respective target substance and each of which emit light at wavelengths different from each other, combination is made with a phosphor nano-particle capable of binding to each of the two or more fluorescent dyes, subsequently irradiation is undertaken with an excitation light which excites the phosphor nano-particle to emit light, and the two or more fluorescent dyes are caused to emit fluorescence using the light from the phosphor nano-particle as an excitation light.

Abstract: The invention provides a fluorescence detecting method, comprising irradiating an excitation light in the UV range on a sample containing a nanoparticle fluorescent material having an emission half-value width of 50 nm to 200 nm as the fluorescent material and detecting the fluorescence emitted from the sample in the visible range.

Abstract: An object of the present invention is to provide a microorganism which has a high ability of producing docosahexaenoic acid. The present invention provides a Thraustochytrium strain which has an ability of producing docosahexaenoic acid, and use thereof.

Abstract: According to an aspect of the invention, there is provided a method for detecting a target compound including: injecting a test liquid containing a target compound into a colloid solution of magnetic nano-particles having an average particle diameter of 50 nm or less to allow the target compound to bind to the magnetic nano-particles, thereby forming bound magnetic nano-particles having a diameter of 100 nm or more; and bringing a dispersion liquid containing the bound magnetic nano-particles in proximity to a magnetic sensor including at least a magnetoresistive (MR) element and a permanent magnet while measuring the change in magnetic resistance to selectively detect the bound magnetic nano-particles, thereby indirectly detecting the target compound.

Abstract: An object of the present invention is to provide a microorganism which has a high ability of producing docosahexaenoic acid. The present invention provides a Thraustochytrium strain which has an ability of producing docosahexaenoic acid, and use thereof.

Abstract: A fastener element for a concealed type slide fastener having a substantially U shaped section including a side edge portion mounting groove for a fastener tape, comprising: a C shaped base portion; flat first and second tape nipping portions extended substantially in parallel from respective front ends of the C shaped base portion; and a coupling portion integrated with an engaging face side on the opposite side to a tape nipping face of the second tape nipping portion, wherein the first tape nipping portion has expanded portions expanded back and forth in a coupling direction, and a front end face of the first tape nipping portion is formed wider than a front end face of the second tape nipping portion, thereby having excellent concealed property and coupling strength and capable of preventing generation of a gap between right and left fastener tapes even if pulling stress is applied.

Abstract: A slider for a concealed type slide fastener for securing a smooth sliding operation even if a strong laterally pulling force is applied when the slide fastener is closed. The slider includes: a lower plate having a pair of flanges each having an inverted L shaped section, the flanges erected along right and left side edges perpendicular to a sliding direction of the slider; a diamond erected toward a gap between upper plate portions of the pair of flanges from a central portion of the lower plate; and element guide portions expanded outwardly toward inside end faces of the upper plate portions from an outer periphery of the diamond, wherein the front ends of the upper plate portion in an engagement direction of the fastener elements are extended forward compared with front end of the element guide portion.

Abstract: It is an object of the present invention to provide a nanoparticle fluorescent material for detecting cancer with which cancer can be detected with high sensitivity, using highly safe and broad light emission on a simple device. The present invention provides a nanoparticle fluorescent material which comprises a metal-oxide or metal-sulfide nanoparticle fluorescent material whose surface is modified by a surface modifying agent and whose half bandwidth of light emission is between 50 and 200 nm, wherein an antibody that recognizes cancer antigen is bound to the surface modifying agent.

Abstract: According to the present invention, there is provided a fluorescent nucleotide represented by the formula: A-B-C, wherein A represents a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue; B represents a divalent linking group or a single bond; and C represents a monovalent group derived from a fluorescent dye having 0 or 1 sulfonic acid group or phosphoric acid group in a molecule. The present invention provides useful fluorescent nucleotides for labeling nucleic acids, specifically, fluorescent nucleotides of which uptake ratio is high in synthetic reaction of nucleic acids.

Abstract: The present invention provides a method of controlling aggregation and dispersion of magnetic nano particles, the method including changing, in a sample liquid containing independently dispersed magnetic nano particles having a particle size of 1 to 50 nm, at least one condition selected from the type of a salt present as a medium, the concentration of the salt, and the pH of the sample liquid to thereby control aggregation and dispersion of the magnetic nano particles.

Abstract: Fluorescent nucleotides useful for labeling nucleic acids which are represented by the formula: X—Y—Z wherein X represents a residue of natural or non-natural nucleotide and the like and binds to Y at a basic moiety of the residue; Y represents a divalent bridging group or a single bond; Z represents a monovalent group derived from a compound represented by the formula (I) wherein R1 to R4 represent an alkyl group; V1 to V6 represent a hydrogen atom or a substituent; L1 to L7 represent a methine group; W represents an oxygen atom, a sulfur atom, —C(R3)(R4)— or —N(R5)— wherein R3 to R5 represents an alkyl group; Q represents a nitrogen atom or —C(V7)— wherein V7 represents a hydrogen atom or a monovalent substituent; M represents a counter ion; m represents a number required to neutralize the charge of the molecule; s, t and u represent 0 or 1 or the like, and binds to Y at a reactive group existing in R1 or R2

Abstract: An object of the present invention is to provide a microorganism which has a high ability of producing docosahexaenoic acid. The present invention provides a Thraustochytrium strain which has an ability of producing docosahexaenoic acid, and use thereof.

Abstract: The present invention provides a fluorescent substance which is represented by a formula: A-B-C wherein A is a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue, or A is a residue of avidin or streptavidin; B is a divalent linking group or a single bond; and C is a monovalent group derived from a general formula (I) and binds to B at a reactive group present in R1 or R2: wherein R1 and R2 each independently represent an alkyl group that may be substituted with a reactive group capable of covalently bonding to A-B-; R3, R4, R5, and R6 each independently represent an alkyl group, and R3 and R4, and/or R5 and R6 may bind to each other to form a saturated carbon-ring together with a carbon atom(s) to which they bind; V1, V2, V3, V4, V5, V6, V7, V8, V9 and V10 each independently represent a hydrogen atom or a monovalent substituent, and two adjacent groups thereof may bind to form a ring; L1, L2,

Abstract: A method for detecting a hybrid multi-stranded nucleic acid sample nucleic acid, which comprises the step of allowing the sample nucleic acid to interact with a probe nucleic acid to form a hybrid multi-stranded nucleic acid by hybridization of the probe nucleic acid and the sample nucleic acid, which further comprises the steps of allowing two or more kinds of compounds with affinity to multi-stranded nucleic acids, each having a different luminescent characteristic, to interact with the hybrid multi-stranded nucleic acid, and then detecting luminescence generated as a result of an energy transfer between the two or more kinds of the compounds with affinity to multi-stranded nucleic acids.

Abstract: Fluorescent nucleotides useful for labeling nucleic acids which are represented by the formula: X—Y—Z wherein X represents a residue of natural or non-natural nucleotide and the like and binds to Y at a basic moiety of the residue; Y represents a divalent bridging group or a single bond; Z represents a monovalent group derived from a compound represented by the formula (I) wherein R1 to R4 represent an alkyl group; V1 to V6 represent a hydrogen atom or a substituent; L1 to L7 represent a methine group; W represents an oxygen atom, a sulfur atom, —C(R3)(R4)— or —N(R5)— wherein R3 to R5 represents an alkyl group; Q represents a nitrogen atom or —C(V7)— wherein V7 represents a hydrogen atom or a monovalent substituent; M represents a counter ion; m represents a number required to neutralize the charge of the molecule; s, t and u represent 0 or 1 or the like, and binds to Y at a reactive group existing in R1 or R2.