Patents by Inventor Masayuki Inui

Masayuki Inui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190119664
    Abstract: Provided is a microorganism that is able to efficiently produce protocatechuic acid or a salt thereof by using a saccharide as a raw material, and a method of efficiently producing protocatechuic acid or a salt thereof by using the microorganism. Provided is a transformant having protocatechuic acid producing ability, subjected to modifications (A), (B), and (C) below: (A) enhancement of 3-dehydroshikimate dehydratase activity; (B) enhancement of chorismate pyruvate lyase activity; and (C) enhancement of 4-hydroxybenzoate hydroxylase activity. Also provided is a method of producing protocatechuic acid or a salt thereof, including the step of culturing the transformant in a reaction solution containing a saccharide so as to cause the transformant to produce protocatechuic acid or a salt thereof.
    Type: Application
    Filed: February 24, 2017
    Publication date: April 25, 2019
    Applicants: RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH, SUMITOMO BAKELITE CO., LTD.
    Inventors: Masayuki INUI, Kazumi HIRAGA, Masako SUDA, Takahisa KOGURE
  • Patent number: 10221409
    Abstract: The mutant chorismate-pyruvate lyase (A) or (B) as described below is capable of producing 4-hydroxybenzoic acid or a salt thereof with sufficient practical efficiency. (A) A mutant chorismate-pyruvate lyase obtained by replacing the valine at position 80 in a chorismate-pyruvate lyase (ubiC) from Pantoea ananatis consisting of the amino acid sequence of SEQ ID NO: 1 with one or more other amino acids. (B) A mutant chorismate-pyruvate lyase obtained by replacing an amino acid in another chorismate-pyruvate lyase, the amino acid being at a position enzymologically homologous with that of the above valine, with one or more other amino acids.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: March 5, 2019
    Assignee: GREEN CHEMICALS CO., LTD.
    Inventors: Hideaki Yukawa, Masayuki Inui, Kazumi Hiraga, Masako Suda, Ryoma Hashimoto
  • Patent number: 10208313
    Abstract: A coryneform bacterium transformant engineered by the following (A) to (D): (A) enhancement of 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase activity; (B) prevention, inhibition, or reduction of intracellular sugar uptake mediated by phosphotransferase system (PTS); (C) enhancement of intracellular sugar uptake activity mediated by a sugar transporter different from phosphotransferase system and enhancement of glucokinase activity; and (D) enhancement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity is capable of efficiently producing shikimic acid or the like from a sugar.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: February 19, 2019
    Assignee: RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH
    Inventors: Masayuki Inui, Masako Suda, Kazumi Hiraga, Takahisa Kogure
  • Patent number: 10195561
    Abstract: A steam supply system that can reheat CO2 absorbing liquid without lowering performance of a reboiler by decompressing a condensed water drum is provided. This system includes a reboiler that raises the temperature of absorbing liquid contacted with exhaust gas discharged from a boiler to absorb CO2 in the exhaust gas and heated to eliminate CO2. The reboiler includes a heat exchanger tube to which steam for heating is supplied and a condensed water drum that recovers condensed water of the steam introduced from the heat exchanger tube as steam drain, and the condensed water drum is provided with decompression unit that lowers pressure in the condensed water drum.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: February 5, 2019
    Assignee: MITSUBISHI HEAVY INDUSTRIES ENGINEERING, LTD.
    Inventors: Koji Nakayama, Takahito Yonekawa, Masayuki Inui, Tatsuya Tsujiuchi, Osamu Miyamoto, Yoshiki Sorimachi
  • Patent number: 10017791
    Abstract: A transformant constructed by introducing a gene which encodes an enzyme having chorismate-pyruvate lyase activity into a coryneform bacterium as a host is capable of efficiently producing 4-hydroxybenzoic acid or a salt thereof from a sugar. When the transformant is cultured under aerobic conditions where the transformant does not grow, 4-hydroxybenzoic acid or a salt thereof can be produced in a particularly efficient manner.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: July 10, 2018
    Assignee: GREEN CHEMICALS CO., LTD.
    Inventors: Hideaki Yukawa, Masayuki Inui, Kazumi Hiraga, Masako Suda, Ryoma Hashimoto
  • Publication number: 20180117524
    Abstract: Included are a CO2 absorber for removing CO2 from a CO2-containing flue gas with a CO2 absorbent, an absorbent regenerator for regenerating the absorbent, a rich solution supply line for supplying the rich solution from the absorber to a rich solution supply portion of the regenerator, a rich/lean solution heat exchanger for exchanging heat between the rich solution and the lean solution, a first rich solution dividing line for dividing the rich solution at a first dividing portion in the rich solution supply line and supplying the divided rich solution at a first supply position on a side wall of the regenerator, a first rich solution heat exchanger for preheating the divided rich solution, and a first flow rate control device for controlling a flow rate of the divided rich solution such that the rich solution is preheated to a predetermined temperature in the first rich solution heat exchanger.
    Type: Application
    Filed: November 1, 2016
    Publication date: May 3, 2018
    Applicant: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Tatsuya Tsujiuchi, Takashi Kamijo, Masayuki Inui, Osamu Miyamoto
  • Publication number: 20180044688
    Abstract: A coryneform bacterium transformant engineered by the following (A) to (D): (A) enhancement of 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase activity; (B) prevention, inhibition, or reduction of intracellular sugar uptake mediated by phosphotransferase system (PTS); (C) enhancement of intracellular sugar uptake activity mediated by a sugar transporter different from phosphotransferase system and enhancement of glucokinase activity; and (D) enhancement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity is capable of efficiently producing shikimic acid or the like from a sugar.
    Type: Application
    Filed: August 20, 2015
    Publication date: February 15, 2018
    Applicant: RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH
    Inventors: Masayuki INUI, Masako SUDA, Kazumi HIRAGA, Takahisa KOGURE
  • Patent number: 9803223
    Abstract: An objective of the present invention is to provide a microorganism capable of efficiently producing aniline from aminobenzoic acid, and a process for efficiently producing aniline from aminobenzoic acid. To achieve the objective, provided is an aniline-producing transformant constructed by introducing a gene which encodes an enzyme having aminobenzoate decarboxylase activity into a coryneform bacterium as a host, characterized in that the enzyme having aminobenzoate decarboxylase activity is composed of an amino acid sequence which is the same as that represented by SEQ ID NO: 2 except for having a mutation of at least proline (P) at position 309 from the N terminus.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: October 31, 2017
    Assignees: RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH, SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Keitarou Fujikura, Kazumi Hiraga, Masayuki Inui, Hideaki Yukawa
  • Publication number: 20170114374
    Abstract: A transformant constructed by introducing a gene which encodes an enzyme having chorismate-pyruvate lyase activity into a coryneform bacterium as a host is capable of efficiently producing 4-hydroxybenzoic acid or a salt thereof from a sugar. When the transformant is cultured under aerobic conditions where the transformant does not grow, 4-hydroxybenzoic acid or a salt thereof can be produced in a particularly efficient manner.
    Type: Application
    Filed: April 7, 2015
    Publication date: April 27, 2017
    Applicant: GREEN PHENOL DEVELOPMENT CO., LTD.
    Inventors: Hideaki YUKAWA, Masayuki INUI, Kazumi HIRAGA, Masako SUDA, Ryoma HASHIMOTO
  • Patent number: 9623366
    Abstract: A CO2 recovery system includes an absorption apparatus that brings a CO2 absorption liquid into contact with an exhaust gas treated by a pre-treatment apparatus so that CO2 in the exhaust gas is absorbed into the CO2 absorption liquid; a regeneration apparatus that separates CO2 from the CO2 absorption liquid; an absorption liquid circulation path that circulates the CO2 absorption liquid between the absorption apparatus and the regeneration apparatus; and an impurity removal unit that removes impurities having a high concentration in the absorption liquid circulation path, in the absorption liquid circulation path and/or in the pre-treatment apparatus in advance.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: April 18, 2017
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Tatsuya Tsujiuchi, Takahito Yonekawa, Shintaro Honjo, Masayuki Inui, Koji Nakayama, Takashi Kamijo, Hiromitsu Nagayasu
  • Publication number: 20170073658
    Abstract: The mutant chorismate-pyruvate lyase (A) or (B) as described below is capable of producing 4-hydroxybenzoic acid or a salt thereof with sufficient practical efficiency. (A) A mutant chorismate-pyruvate lyase obtained by replacing the valine at position 80 in a chorismate-pyruvate lyase (ubiC) from Pantoea ananatis consisting of the amino acid sequence of SEQ ID NO: 1 with one or more other amino acids. (B) A mutant chorismate-pyruvate lyase obtained by replacing an amino acid in another chorismate-pyruvate lyase, the amino acid being at a position enzymologically homologous with that of the above valine, with one or more other amino acids.
    Type: Application
    Filed: May 13, 2015
    Publication date: March 16, 2017
    Applicant: GREEN PHENOL DEVELOPMENT CO., LTD.
    Inventors: Hideaki YUKAWA, Masayuki INUI, Kazumi HIRAGA, Masako SUDA, Ryoma HASHIMOTO
  • Patent number: 9453248
    Abstract: Provided is an aniline-producing transformant constructed by introducing a gene which encodes an enzyme having aminobenzoate decarboxylase activity into a coryneform bacterium as a host. Also provided is a process for producing aniline, which comprises a step of allowing the transformant to react in a reaction mixture containing aminobenzoic acid, an ester thereof, and/or a salt thereof under reducing conditions, and a step of recovering aniline from the reaction mixture.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: September 27, 2016
    Assignees: RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH, SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Hideaki Yukawa, Masayuki Inui
  • Patent number: 9433890
    Abstract: In a dehydration equipment, a regenerative gas heater heats a portion of CO2 gas dehydrated in an adsorption tower that is performing an adsorption process and supplies the gas to an adsorption tower that is performing a regeneration process. A regenerative gas preheater performs heat exchange between the CO2 gas that will be supplied to a regenerative gas heater and the CO2 gas sent out from the adsorption tower that is performing the regeneration process. Then, in the dehydration equipment, a regenerative gas cooler cools the CO2 gas that has been sent out from the adsorption tower that is performing the regeneration process and exchanged heat, separates water from the cooled CO2 gas, and returns the resulting gas to the adsorption tower. Thus, the dehydration equipment can prevent an increase in utility consumption due to the regeneration process.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: September 6, 2016
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Masayuki Inui, Takahito Yonekawa, Koji Nakayama, Tatsuya Tsujiuchi, Yoshiki Sorimachi
  • Patent number: 9404115
    Abstract: Provided is a phenol-producing transformant constructed by transferring a gene which encodes an enzyme having chorismate-pyruvate lyase activity and a gene which encodes an enzyme having 4-hydroxybenzoate decarboxylase activity into a coryneform bacterium as a host. Also provided is a process for producing phenol, which comprises a step of allowing the transformant to react in a reaction mixture containing a saccharide under reducing conditions, and a step of collecting phenol from the reaction mixture.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: August 2, 2016
    Assignee: GREEN PHENOL DEVELOPMENT CO., LTD.
    Inventors: Hideaki Yukawa, Masayuki Inui
  • Patent number: 9381461
    Abstract: SOx removal equipment 15 which reduces sulfur oxides from flue gas 12 from a boiler 11, a cooler 16 which is provided on the downstream side of the SOx removal equipment 15 so as to reduce the sulfur oxides from the flue gas and decrease a gas temperature, CO2 recovery equipment 17 which includes an absorber for bringing CO2 in the flue gas into contact with a CO2 absorption liquid so as to be reduced and a regenerator for causing the CO2 absorption liquid to emit CO2 so as to recover CO2 and regenerate the CO2 absorption liquid, and ammonia injection equipment 22 for reducing a mist generation material which is a generation source of mist that is generated in the absorber of the CO2 recovery equipment before introducing the flue gas to the CO2 recovery equipment, are included.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: July 5, 2016
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Tatsuto Nagayasu, Takashi Kamijo, Masayuki Inui, Tsuyoshi Oishi, Hiromitsu Nagayasu, Hiroshi Tanaka, Takuya Hirata, Tatsuya Tsujiuchi, Susumu Okino, Naoyuki Kamiyama, Seiji Yoshihara
  • Patent number: 9352273
    Abstract: There is provided a dehydration-compression system 10 in which CO2 loss is suppressed, and a CO2 recovery system including the dehydration-compression system. The dehydration-compression system 10 of the present invention includes multiple compressors 50 and a dehydration device 60. The dehydration device 60 includes: a contactor 62 which removes H2O contained in CO2 by absorbing the H2O into an dehydration solvent; a recovery part 74 which recovers the CO2 from the dehydration solvent discharged from the contactor 62; and a first circulating passage L31 which carries the CO2 released from the recovery part 74 to the upstream side of the contactor 62.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: May 31, 2016
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Masayuki Inui, Takahito Yonekawa, Cole Maas, Tatsuya Tsujiuchi
  • Publication number: 20160130617
    Abstract: Provided is an aniline-producing transformant constructed by introducing a gene which encodes an enzyme having aminobenzoate decarboxylase activity into a coryneform bacterium as a host. Also provided is a process for producing aniline, which comprises a step of allowing the transformant to react in a reaction mixture containing aminobenzoic acid, an ester thereof, and/or a salt thereof under reducing conditions, and a step of recovering aniline from the reaction mixture.
    Type: Application
    Filed: December 29, 2015
    Publication date: May 12, 2016
    Inventors: Hideaki Yukawa, Masayuki Inui
  • Patent number: 9327229
    Abstract: SOx removal equipment 15 which reduces sulfur oxides from flue gas 12 from a boiler 11, a cooler 16 which is provided on the downstream side of the SOx removal equipment 15 so as to reduce the sulfur oxides from the flue gas and decrease a gas temperature, CO2 recovery equipment 17 which includes an absorber for bringing CO2 in the flue gas into contact with a CO2 absorption liquid so as to be reduced and a regenerator for causing the CO2 absorption liquid to emit CO2 so as to recover CO2 and regenerate the CO2 absorption liquid, and ammonia injection equipment 22 for reducing a mist generation material which is a generation source of mist that is generated in the absorber of the CO2 recovery equipment before introducing the flue gas to the CO2 recovery equipment, are included.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: May 3, 2016
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Tatsuto Nagayasu, Takashi Kamijo, Masayuki Inui, Tsuyoshi Oishi, Hiromitsu Nagayasu, Hiroshi Tanaka, Takuya Hirata, Tatsuya Tsujiuchi, Susumu Okino, Naoyuki Kamiyama, Seiji Yoshihara
  • Patent number: 9328361
    Abstract: A phenol-producing transformant is provided which can efficiently produce phenol from a saccharide. A gene which encodes an enzyme having tyrosine phenol-lyase activity is transferred into Corynebacterium glutamicum as a host. A process for producing phenol is provided having a step of reacting the transformant in a reaction mixture containing a saccharide under reducing conditions, and a step of collecting phenol from the reaction mixture.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: May 3, 2016
    Assignee: GREEN PHENOL DEVELOPMENT CO., LTD.
    Inventors: Hideaki Yukawa, Masayuki Inui
  • Patent number: 9290770
    Abstract: A transformant obtainable by introducing one or more of the following DNAs (a), (b), and (c) into a coryneform bacterium as a host. (a) A DNA which encodes acetohydroxy acid synthase derived from Corynebacterium glutamicum and which has a mutation changing the glycine at position 156 to glutamic acid (G156E) in an amino acid sequence encoded by the DNA, or an analog thereof. (b) A DNA which encodes acetohydroxy acid isomeroreductase derived from Corynebacterium glutamicum and which has mutations changing the serine at position 34 to glycine (S34G), the leucine at position 48 to glutamic acid (L48E), and the arginine at position 49 to phenylalanine (R49F) in an amino acid sequence encoded by the DNA, or an analog thereof. (c) A DNA which encodes leucine dehydrogenase derived from Lysinibacillus sphaericus, or an analog thereof.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: March 22, 2016
    Assignee: RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH
    Inventors: Hideaki Yukawa, Masayuki Inui