Abstract: [Problem] It is desired to develop an antibody-drug conjugate capable of being systemically administered and delivering a STING agonist specifically to a target cells or organ (for example, a tumor lesion), and a therapeutic agent and/or therapeutic method using the antibody-drug conjugate for diseases related to STING agonist activity, for example, diseases (for example, cancers) to which immunostimulation therapy can be applied. [Solution] The present invention provides a novel antibody-CDN derivative conjugate which can be systemically administered and exhibits an antitumor effect against an antigen-expressing tumor.

Abstract: Desired is development of novel CDN derivatives having STING agonist activity; and a therapeutic agents and/or therapeutic methods using the novel CDN derivatives for diseases associated with STING agonist activity. Further desired is development of a therapeutic agents and/or therapeutic methods capable of delivering the novel CDN derivatives specifically to targeted cells and organs for diseases associated with STING agonist activity. The present invention provides novel CDN derivatives having potent STING agonist activity, and antibody-CDN derivative conjugates including the novel CDN derivatives.

Abstract: A wireless sensor network system includes: sensor terminals and a management terminal. A sensor terminal sends a join request at a first transmission power; and the management terminal calculates the traffic load of nodes on the reception path of the join request. If the number of hops and the traffic load are both within respective permissible ranges, the management terminal sets the reception path as the communication route of the sensor terminal. If the number of hops and/or the load is not within the permissible rage, the management terminal reconstructs the communication path by outputting an instruction to the sensor terminal to make direct connection to the management terminal or a specified node with a low traffic load, at a second transmission power greater than the first transmission power. When receiving the instruction, the sensor terminal transmits to the management terminal or the specified node at the second transmission power.

Abstract: A wireless sensor network system includes: sensor terminals and a management terminal. A sensor terminal sends a join request at a first transmission power; and the management terminal calculates the traffic load of nodes on the reception path of the join request. If the number of hops and the traffic load are both within respective permissible ranges, the management terminal sets the reception path as the communication route of the sensor terminal. If the number of hops and/or the load is not within the permissible rage, the management terminal reconstructs the communication path by outputting an instruction to the sensor terminal to make direct connection to the management terminal or a specified node with a low traffic load, at a second transmission power greater than the first transmission power. When receiving the instruction, the sensor terminal transmits to the management terminal or the specified node at the second transmission power.

Abstract: A wireless sensor network system includes: sensor terminals and a management terminal. A sensor terminal sends a join request at a first transmission power; and the management terminal calculates the traffic load of nodes on the reception path of the join request. If the number of hops and the traffic load are both within respective permissible ranges, the management terminal sets the reception path as the communication route of the sensor terminal. If the number of hops and/or the load is not within the permissible rage, the management terminal reconstructs the communication path by outputting an instruction to the sensor terminal to make direct connection to the management terminal or a specified node with a low traffic load, at a second transmission power greater than the first transmission power. When receiving the instruction, the sensor terminal transmits to the management terminal or the specified node at the second transmission power.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Abstract: A wireless sensor network system includes: sensor terminals and a management terminal. A sensor terminal sends a join request at a first transmission power; and the management terminal calculates the traffic load of nodes on the reception path of the join request. If the number of hops and the traffic load are both within respective permissible ranges, the management terminal sets the reception path as the communication route of the sensor terminal. If the number of hops and/or the load is not within the permissible rage, the management terminal reconstructs the communication path by outputting an instruction to the sensor terminal to make direct connection to the management terminal or a specified node with a low traffic load, at a second transmission power greater than the first transmission power. When receiving the instruction, the sensor terminal transmits to the management terminal or the specified node at the second transmission power.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Abstract: The number of wasteful attempts at wireless data transmission to any wireless terminal with which communication is impossible is to be reduced. The wireless terminal constantly monitors the state of communication between wireless terminals and, when any change in the state of communication is found, one set or plural sets of data awaiting wireless transmission are checked to see whether or not they are destined for any wireless terminal with which communication is possible, the data being discarded if wireless communication is determined to be impossible. The number of wasteful attempts at wireless data transmission can be thereby reduced.

Abstract: A digital broadcast signal distribution system includes subscriber terminals each of which includes a distribution plan storage for retaining channel distribution plans, one representing distribution setting information of each of the plural distribution centers; a distribution center discriminating section for discriminating the one distribution center that has created a digital broadcast distribution signal received in the subscriber terminal; and a receiving section for changing, if the one distribution center is discriminated not to be a predetermined distribution center, NIT information of the first-named digital broadcast distribution signal based on the channel distribution plans of the one distribution center and the predetermined distribution center, and receiving the digital broadcast distribution signal. Whereupon the system can always distribute a good digital broadcast distribution signal and can be constructed at a low cost.

Abstract: A random-number generator generates first and second title keys on the basis of random numbers. A first DES encryption circuit for the title encrypts input data with the first title key. Initial values of this item of input data are a data identifier (ID) and program clock reference (PCR) that are extracted from a packet header. After completing the encryption of the initial values, a result of an encryption by a second DES encryption circuit for title serves as the input data for the first DES encryption circuit for title. The second DES encryption circuit for title encrypts a value of result of the encryption by the first DES encryption circuit for title with the second title key. An exclusive OR circuit outputs an exclusive OR of the data stored in the packet and a value of result of the encryption by the second DES encryption circuit for title. This exclusive OR turns out encrypted data.

Abstract: The two-way communication system which provides program information distributed in a predetermined broadcasting system from a program information provider for a CATV subscriber through a CATV network, processes return information returned from the CATV subscriber, and transmits the processed information to the program information provider is disclosed.

Abstract: On delivering a program on an On Demand method of a Cable TV, program reservation information is generated for each route of a communication line in a Cable TV center and is provided to a subscriber in order to restrain the number of digital lines in respect of the number of subscribers in a predetermined number and efficiently utilize equipment set in the center's side while maintaining the On Demand service to the subscriber. The subscriber thereby can recognize a reservation status of a program in respect of his or her own route and, if he or she desires simultaneous delivery of a program already reserved, an overlapping reservation of the program a third party reserved can be made. Communication lines can be efficiently utilized by simultaneously transmitting a program to the same communication line in this way.

Abstract: An information center transmits information as the object of sales to each information vending machine in advance through a communication line and stores it in the information storage portion of each information vending machine. Each information vending machine stores correspondence list which specifies the correspondence of each information vending machine with the information as the object of sales which is stored therein. When the information vending machine operated does not store the information requested by a purchaser in the information storage portion thereof, the information vending machine refers to the correspondence list, finds other information vending machine which stores the requested information, receives the information from the other information vending machine through the communication line and copies the information on a recording medium so as to sell the information.

Abstract: An information distribution system for distributing information, containing: a first station for transmitting a first signal carrying information to at least one second station; the at least one second station for receiving the first signal, and transmitting a second signal carrying the information to an area around a place at which the second station is located; and at least one terminal for receiving the second signal, and displaying the information. The second signal is a wireless signal. The at least one terminal contains, a wireless receiver unit for receiving the second signal, a storage unit for storing the information, a display unit for displaying the information stored in the storage unit, a display control unit for controlling the storage unit and the display unit in accordance with a display command, and a unit for inputting the display command for commanding the display control unit how the information stored in the storage unit is to be displayed.

Abstract: A key management unit of a service provider system generates an individual key corresponding to a portable module connected to a service client making an access request and informs an authenticating unit of this individual key. The individual key is stored beforehand also in the portable module. A random-number generator generates a random number, transmits this random number to the portable module and informs the authenticating unit of it. The portable module encrypts the random number with the individual key and sends it back to the service provider system. An encrypting portion of the authenticating unit encrypts the random number with the individual key. A comparator of the authenticating unit compares data encrypted by the encrypting portion with encrypted data transmitted from the portable module and, if the two items of data are coincident with each other, confirms an access request from the portable module.

Abstract: An automatic vending machine for vending information, containing: a receiving unit for receiving a signal carrying first information transmitted from a satellite; a storage unit for storing the first information; a buying request input unit for receiving a request for buying the information; a charge receiving unit for receiving a charge for the first information; and an information output unit for reading the first information requested by the request from the storage unit and outputting the first information when the request and the charge is received.

Abstract: A method of protecting data in an IC memory card (11) having a ROM area (11a) and a RAM area (11b) and used as an external storage medium of a computer system includes storing key data for preventing copying in the ROM area and using the key data to prevent the copying of data stored in the RAM area. For example, when a file is written, second key data (k1, k2, . . . ), which is inserted into the headers (H1, H2, . . . ) of files (11c-1, 11c-2 . . . ), is decided in such a manner that a fixed correlation will exist with respect to first key data (K1, K2, . . . ) stored in the ROM area (11a), and the second key data is written in the RAM area (11b). When a file is read out of the IC memory card, a check is performed to determine whether the fixed correlation holds between the first key data that has been written in the ROM area and the second key data that has been inserting into the header of the file. The file is read out only if the fixed correlation holds.