Abstract: Signal components of different physiological origins are accurately separated and information about each component is provided, even when a signal change related to local neuronal activity and signal fluctuations related to other physiological origins coexist. It is achieved by a method for separating and extracting information on physiological functions, wherein a mathematical model is built to describe an input/output relationship for functional measurement data on a pixel or channel basis, and information on signal components of various physiological origins is separated and extracted from the functional measurement data.