Patents by Inventor Masayuki Matsukura
Masayuki Matsukura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7468380Abstract: A compound represented by the general formula: wherein X1 represents a nitrogen atom or a group represented by the formula —CR10?; X2 represents a nitrogen atom or a group represented by the formula —CR11?; Y represents an oxygen atom or the like; R1 represents a C1-6 alkoxy group, an optionally substituted C6-10 aryloxy group, a group represented by the formula —NR12aR12b or the like; R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like; R3, R4, R5, R6, R7, R8, R10 and R11 each independently represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or the like; R9 represents a group represented by the formula —NR16aR16b or the like; and R12a, R12b, R16a and R16b each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, a salt thereof, or a hydrate of the foregoing.Type: GrantFiled: August 18, 2006Date of Patent: December 23, 2008Assignee: Eisai R&D Management Co., Ltd.Inventors: Akihiko Tsuruoka, Tomohiro Matsushima, Masayuki Matsukura, Kazuki Miyazaki, Keiko Takahashi, Junichi Kamata, Yoshio Fukuda
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Publication number: 20080275244Abstract: There is provided a heterocycle-substituted pyridine derivative's salt or a crystal thereof. The present invention provides an acid addition salt of 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine or a crystal thereof as well as process for producing the same.Type: ApplicationFiled: April 25, 2008Publication date: November 6, 2008Inventors: Jun Niijima, Kazutaka Nakamoto, Masayuki Matsukura, Keigo Tanaka, Eiichi Yamamoto, Takuma Minamisono
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Patent number: 7253286Abstract: Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—, Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.Type: GrantFiled: April 18, 2003Date of Patent: August 7, 2007Assignee: Eisai Co., LtdInventors: Yasuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken-ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui, Kenji Matsui, Takako Yoshiba, Yasuyuki Suzuki, Itaru Arimoto
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Publication number: 20070105904Abstract: An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability.Type: ApplicationFiled: October 30, 2006Publication date: May 10, 2007Applicant: Eisai R&D Management Co., Ltd.Inventors: Keigo Tanaka, Satoshi Inoue, Norio Murai, Masayuki Matsukura, Kazutaka Nakamoto, Shuji Shirotori, Shinya Abe
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Publication number: 20070105943Abstract: The present invention provides an antifungal agent represented by the formula: [wherein A1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X1 represents a group represented by the formula —NH—C(?O)—, a group represented by the formula —C(?O)—NH—, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A1 may have 1 to 3 substituents, and E has one or two substituents].Type: ApplicationFiled: September 27, 2004Publication date: May 10, 2007Inventors: Kazutaka Nakamoto, Itaru Tsukada, Keigo Tanaka, Masayuki Matsukura, Toru Haneda, Satoshi Inoue, Norihiro Ueda, Shinya Abe, Katsura Hata, Naoaki Watanabe
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Publication number: 20070004764Abstract: A compound represented by the general formula: wherein X1 represents a nitrogen atom or a group represented by the formula —CR10?; X2 represents a nitrogen atom or a group represented by the formula —CR11?; Y represents an oxygen atom or the like; R1 represents a C1-6 alkoxy group, an optionally substituted C6-10 aryloxy group, a group represented by the formula —NR12aR12b or the like; R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like; R3, R4, R5, R6, R7, R8, R10 and R11 each independently represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or the like; R9 represents a group represented by the formula —NR16aR16b or the like; and R12a, R12b, R16a and R16b each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, a salt thereof, or a hydrate of the foregoing.Type: ApplicationFiled: August 18, 2006Publication date: January 4, 2007Inventors: Akihiko Tsuruoka, Tomohiro Matsushima, Masayuki Matsukura, Kazuki Miyazaki, Keiko Takahashi, Junichi Kamata, Yoshio Fukuda
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Publication number: 20060247259Abstract: Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—, Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.Type: ApplicationFiled: December 2, 2005Publication date: November 2, 2006Inventors: Yasuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken-ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui, Kenji Matsui, Takako Yoshiba, Yasuyuki Suzuki, Itaru Arimoto
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Patent number: 7109219Abstract: A compound represented by the general formula: wherein X1 represents a nitrogen atom or a group represented by the formula —CR10?; X2 represents a nitrogen atom or a group represented by the formula —CR11?; Y represents an oxygen atom or the like; R1 represents a C1-6 alkoxy group, an optionally substituted C6-10 aryloxy group, a group represented by the formula —NR12aR12b or the like; R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like; R3, R4, R5, R6, R7, R8, R10 and R11 each independently represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or the like; R9 represents a group represented by the formula —NR12aR12b or the like; and R12a and R12b each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, a salt thereof, or a hydrate of the foregoing.Type: GrantFiled: August 29, 2003Date of Patent: September 19, 2006Assignee: Eisai Co., Ltd.Inventors: Akihiko Tsuruoka, Tomohiro Matsushima, Masayuki Matsukura, Kazuki Miyazaki, Keiko Takahashi, Junichi Kamata, Yoshio Fukuda
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Publication number: 20060160832Abstract: Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—, Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.Type: ApplicationFiled: February 3, 2006Publication date: July 20, 2006Inventors: Yosuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken-ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui, Kenji Matsui, Takako Yoshiba, Yasuyuki Suzuki, Itaru Arimoto
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Publication number: 20050187236Abstract: A compound represented by the general formula: wherein X1 represents a nitrogen atom or a group represented by the formula —CR10?; X2 represents a nitrogen atom or a group represented by the formula —CR11?; Y represents an oxygen atom or the like; R1 represents a C1-6 alkoxy group, an optionally substituted C6-10 aryloxy group, a group represented by the formula —NR12aR12b or the like; R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like; R3, R4, R5, R6, R7, R8, R10 and R11 each independently represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or the like; R9 represents a group represented by the formula —NR16aR16b or the like; and R12a, R12b, R16a and R16b each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, a salt thereof, or a hydrate of the foregoing.Type: ApplicationFiled: August 29, 2003Publication date: August 25, 2005Inventors: Akihiko Tsuruoka, Tomohiro Matsushima, Masayuki Matsukura, Kazuki Miyazaki, Keiko Takahashi, Junichi Kamata, Yoshio Fukuda
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Patent number: 6784192Abstract: The present invention provides a novel compound having a superior Na+ channel inhibitory activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the ring A represents a ring represented by the formula: (wherein R1 represents a hydrogen atom etc.; and R2 represents indicates a hydrogen atom and the like) etc.; W represents an optionally substituted C1-6 alkylene group etc.; Z represents an optionally substituted C6-14 aromatic hydrocarbon cyclic group etc.; and l represents an integer from 0 to 6.Type: GrantFiled: July 19, 2002Date of Patent: August 31, 2004Assignee: Eisai Co., Ltd.Inventors: Fumihiro Ozaki, Toshihiko Kaneko, Mutsuko Tabata, Yoshinori Takahashi, Kazuki Miyazaki, Junichi Kamata, Ichiro Yoshida, Masayuki Matsukura, Hiroyuki Suzuki, Takashi Yoshinaga, Hiroki Ishihara, Hiroshi Katoh, Kohei Sawada, Tatsuhiro Onogi, Kiyoaki Kobayashi, Miyuki Ohkubo
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Publication number: 20040053908Abstract: Compounds represented by the following general formula: 1Type: ApplicationFiled: April 18, 2003Publication date: March 18, 2004Inventors: Yasuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken-ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui, Kenji Matsui, Takako Yoshiba, Yasuyuki Suzuki, Itaru Arimoto
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Publication number: 20030220368Abstract: The present invention provides a novel compound having a superior Na+ channel inhibition activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them.Type: ApplicationFiled: July 19, 2002Publication date: November 27, 2003Inventors: Fumihiro Ozaki, Toshihiko Kaneko, Mutsuko Tabata, Yoshinori Takahashi, Kazuki Miyazaki, Junichi Kamata, Ichiro Yoshida, Masayuki Matsukura, Hiroyuki Suzuki, Takashi Yoshinaga, Hiroki Ishihara, Hiroshi Katoh, Kohei Sawada, Tatsuhiro Onogi, Kiyoaki Kobayashi, Miyuki Ohkubo
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Patent number: 6218392Abstract: A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as “cGMP-PDE”). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma.Type: GrantFiled: September 29, 1998Date of Patent: April 17, 2001Assignee: Eisai Co., Ltd.Inventors: Nobuhisa Watanabe, Yasuhiro Kabasawa, Yasutaka Takase, Fumihiro Ozaki, Keiji Ishibashi, Kazuki Miyazaki, Masayuki Matsukura, Shigeru Souda, Kazutoshi Miyake, Hiroki Ishihara, Kohtaro Kodama, Hideyuki Adachi
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Patent number: 5849741Abstract: A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE").The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma.Type: GrantFiled: April 9, 1996Date of Patent: December 15, 1998Assignee: Eisai Co., Ltd.Inventors: Nobuhisa Watanabe, Yasuhiro Kabasawa, Yasutaka Takase, Fumihiro Ozaki, Keiji Ishibashi, Kazuki Miyazaki, Masayuki Matsukura, Shigeru Souda, Kazutoshi Miyake, Hiroki Ishihara, Kohtaro Kodama, Hideyuki Adachi
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Patent number: 5606073Abstract: Propenoic acid derivatives of the formula: ##STR1## where R.sup.15 and R.sup.17 are aryl or heteroalkyl groups and R.sup.16 and R.sup.18 are hydrogen, a lower alkyl or the like are intermediates used to prepare pharmaceutically active diazole propenoic acid compounds.Type: GrantFiled: April 11, 1995Date of Patent: February 25, 1997Assignee: Eisai Co., Ltd.Inventors: Masayuki Matsukura, Keizoh Satoh, Naoki Yoneda, Makoto Kaino, Kazutoshi Miyake, Yoshiharu Daiku, Naoya Kishi, Fusayo Yoshida, Kenichi Nomoto, Toshiaki Ogawa, Tadanobu Takamura, Koichi Nose, Mikio Tomimatsu, Masanori Mizuno, Shigeto Negi, Shigeru Souda
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Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility
Patent number: 5541213Abstract: A novel propenoic acid derivative which exhibits adenosine A1 antagonism is defined by the general formula (I): ##STR1## (wherein A represents an aromatic ring; R.sup.1 represents aryl or the like; R.sup.2, R.sup.3 and R.sup.4 each represent hydrogen, lower alkyl or the like; and R.sup.7 and R.sup.8 each represent lower alkyl or the like) or a pharmacologically acceptable salt thereof.Type: GrantFiled: June 10, 1994Date of Patent: July 30, 1996Assignee: Eisai Co., Ltd.Inventors: Masayuki Matsukura, Keizoh Satoh, Naoki Yoneda, Makoto Kaino, Kazutoshi Miyake, Yoshiharu Daiku, Naoya Kishi, Fusayo Yoshida, Kenichi Nomoto, Toshiaki Ogawa, Tadanobu Takamura, Koichi Nose, Mikio Tomimatsu, Masanori Mizuno, Shigeto Negi, Shigeru Souda -
Patent number: 5506238Abstract: The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1=A2--A3=A4-- is --CH=CH--CH=CH--, --N=CH--CH=CH--, --CH=N--CH=CH--, --CH=CH--N=CH--, --CH=CH--CH=N-- or --CH=N--CH=N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.Type: GrantFiled: May 1, 1992Date of Patent: April 9, 1996Assignee: Eisai Co., Ltd.Inventors: Kazutoshi Miyake, Masayuki Matsukura, Naoki Yoneda, Osamu Hiroshima, Nobuyuki Mori, Hiroki Ishihara, Takashi Musha, Toshiyuki Matsuoka, Sachiyuki Hamano, Norio Minami
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Patent number: 5328911Abstract: The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is --CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.Type: GrantFiled: September 13, 1990Date of Patent: July 12, 1994Assignee: Eisai Co., Ltd.Inventors: Kazutoshi Miyake, Masayuki Matsukura, Naoki Yoneda, Osamu Hiroshima, Nobuyuki Mori, Hiroki Ishihara, Takashi Musha, Toshiyuki Matsuoka, Sachiyuki Hamano, Norio Minami
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Patent number: 5298518Abstract: The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.Type: GrantFiled: March 6, 1992Date of Patent: March 29, 1994Assignee: Eisai Co., Ltd.Inventors: Kazutoshi Miyake, Masayuki Matsukura, Naoki Yoneda, Osamu Hiroshima, Nobuyuki Mori, Hiroki Ishihara, Takashi Musha, Toshiyuki Matsuoka, Sachiyuki Hamano, Norio Minami