Patents by Inventor Masayuki Okue
Masayuki Okue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11414429Abstract: Provided are 2-(piperidin-1-yl)pyrimidin-4(3H)-ones or pharmaceutically acceptable salts thereof, each characterized by having a 1,8-diazaspiro[4.5]deca-3-ene, 1-oxa-8-azaspiro[4.5]deca-3-ene, 2,8-diazaspiro[4.5]deca-3-ene, 2-oxa-8-azaspiro[4.5]deca-3-ene, 2,9-diazaspiro[5.5]undeca-3-ene, 1-oxa-9-azaspiro[5.5]undeca-3-ene, 1,9-diazaspiro[5.5]undeca-4-ene, or 3,9-diazaspiro[5.Type: GrantFiled: June 30, 2017Date of Patent: August 16, 2022Assignees: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCH, KABUSHIKI KAISHA YAKULT HONSHAInventors: Minoru Yoshida, Hiroyuki Seimiya, Masayuki Okue, Yoko Yashiroda, Fumiyuki Shirai, Takeshi Tsumura, Yuko Kano, Kenichi Washizuka, Nobuko Yoshimoto, Yasuko Kouda, Takehiro Fukami, Tsubasa Chikada, Takashi Watanabe
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Publication number: 20200172554Abstract: Provided are 2-(piperidin-1-yl)pyrimidin-4(3H)-ones or pharmaceutically acceptable salts thereof, each characterized by having a 1,8-diazaspiro[4.5]deca-3-ene, 1-oxa-8-azaspiro[4.5]deca-3-ene, 2,8-diazaspiro[4.5]deca-3-ene, 2-oxa-8-azaspiro[4.5]deca-3-ene, 2,9-diazaspiro[5.5]undeca-3-ene, 1-oxa-9-azaspiro[5.5]undeca-3-ene, 1,9-diazaspiro[5.5]undeca-4-ene, or 3,9-diazaspiro[5.Type: ApplicationFiled: June 30, 2017Publication date: June 4, 2020Applicants: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCHInventors: Minoru YOSHIDA, Hiroyuki SEIMIYA, Masayuki OKUE, Yoko YASHIRODA, Fumiyuki SHIRAI, Takeshi TSUMURA, Yuko KANO, Kenichi WASHIZUKA, Nobuko YOSHIMOTO, Yasuko KOUDA, Takehiro FUKAMI, Tsubasa CHIKADA, Takashi WATANABE
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Patent number: 9676777Abstract: An optically active (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid compound defined by the following formula (F): wherein R1 represents CO2R, CO2M, or CONH2, wherein R represents an allyl group or a benzyl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R2 represents a benzyl group or an allyl group.Type: GrantFiled: January 27, 2016Date of Patent: June 13, 2017Assignee: MEIJI SEIKA PHARMA CO., LTD.Inventors: Takao Abe, Masayuki Okue, Yoshiaki Sakamaki
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Publication number: 20160137645Abstract: An optically active (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid compound defined by the following formula (F): wherein R1 represents CO2R, CO2M, or CONH2, wherein R represents an allyl group or a benzyl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R2 represents a benzyl group or an allyl group.Type: ApplicationFiled: January 27, 2016Publication date: May 19, 2016Applicant: Meiji Seika Pharma Co., Ltd.Inventors: Takao ABE, Masayuki OKUE, Yoshiaki SAKAMAKI
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Patent number: 9284273Abstract: A compound of the following compound (B): wherein tBu represents a tert-butyl group. A compound of the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.Type: GrantFiled: April 1, 2015Date of Patent: March 15, 2016Assignee: MEIJI SEIKA PHARMA CO., LTD.Inventors: Takao Abe, Masayuki Okue, Yoshiaki Sakamaki
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Publication number: 20150239840Abstract: A compound of the following compound (B): , wherein tBu represents a tert-butyl group. A compound of the following compound (C): , wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.Type: ApplicationFiled: April 1, 2015Publication date: August 27, 2015Applicant: Meiji Seika Pharma Co., Ltd.Inventors: Takao ABE, Masayuki OKUE, Yoshiaki SAKAMAKI
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Patent number: 9035062Abstract: A process for preparing the compound of the following formula (E): wherein Bn represents a benzyl group, and tBu represents a tert-butyl group, the process including: (a) subjecting the following compound (B) to trifluoroacetylation, wherein tBu represents a tert-butyl group to produce the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; (b) reacting the compound (C) with benzyloxyamine in the presence of a hydroxyl group activating agent to produce the following compound (D): wherein Bn represents a benzyl group, tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; and (c) subjecting the compound (D) to detrifluoroacetylation.Type: GrantFiled: May 27, 2014Date of Patent: May 19, 2015Assignee: MEIJI SEIKA PHARMA CO., LTD.Inventors: Takao Abe, Masayuki Okue, Yoshiaki Sakamaki
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Publication number: 20140303375Abstract: A process for preparing the compound of the following formula (E): wherein Bn represents a benzyl group, and tBu represents a tert-butyl group, the process including: (a) subjecting the following compound (B) to trifluoroacetylation, wherein tBu represents a tert-butyl group to produce the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; (b) reacting the compound (C) with benzyloxyamine in the presence of a hydroxyl group activating agent to produce the following compound (D): wherein Bn represents a benzyl group, tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; and (c) subjecting the compound (D) to detrifluoroacetylation.Type: ApplicationFiled: May 27, 2014Publication date: October 9, 2014Applicant: Meiji Seika Pharma. Co., Ltd.Inventors: Takao ABE, Masayuki OKUE, Yoshiaki SAKAMAKI
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Patent number: 8772490Abstract: Provided are an optically active diazabicyclooctane derivative defined by formula (F) below, which is useful as a pharmaceutical intermediate for ?-lactamase inhibitor, and a process for preparing the same. In formula (F) above, R1 represents CO2R, CO2M, or CONH2, wherein R represents a methyl group, a tert-butyl group, an allyl group, a benzyl group, or a 2,5-dioxopyrrolidin-1-yl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R2 represents a benzyl group or an allyl group.Type: GrantFiled: June 30, 2011Date of Patent: July 8, 2014Assignee: Meiji Seika Pharma Co., Ltd.Inventors: Takao Abe, Masayuki Okue, Yoshiaki Sakamaki
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Publication number: 20120165533Abstract: Provided are an optically active diazabicyclooctane derivative defined by formula (F) below, which is useful as a pharmaceutical intermediate for ?-lactamase inhibitor, and a process for preparing the same. In formula (F) above, R1 represents CO2R, CO2M, or CONH2, wherein R represents a methyl group, a tert-butyl group, an allyl group, a benzyl group, or a 2,5-dioxopyrrolidin-1-yl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R2 represents a benzyl group or an allyl group.Type: ApplicationFiled: June 30, 2011Publication date: June 28, 2012Applicant: MEIJI SEIKA PHARMA CO., LTD.Inventors: Takao ABE, Masayuki Okue, Yoshiaki Sakamaki
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Patent number: 6689798Abstract: The present invention provides novel benzofuran derivatives represented by the following formula (I) or salts thereof: wherein Py is a 2-, 3-, or 4-pyridyl group and R is a substituted or unsubstituted phenyl group or a substituted or unsubstituted aromatic heterocyclic group. The present invention also relates to inhibitors of steroid 17&agr;-hydroxylase and/or steroid C17-20 lyase and pharmaceutical compositions containing a benzofuran derivative of the above formula (I), or the salt.Type: GrantFiled: November 18, 2002Date of Patent: February 10, 2004Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Shin'ichi Shimada, Shin Nomoto, Masayuki Okue, Ken'ichi Kimura, Junji Nakamura, Yoshikazu Ikeda, Takeko Takada
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Publication number: 20030149079Abstract: The present invention provides novel benzofuran derivatives represented by the following formula (I) or salts thereof: 1Type: ApplicationFiled: November 18, 2002Publication date: August 7, 2003Applicant: Daiichi Pharmaceutical Co., Ltd.Inventors: Shin?apos;ichi Shimada, Shin Nomoto, Masayuki Okue, Ken?apos;ichi Kimura, Junji Nakamura, Yoshikazu Ikeda, Takeko Takada
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Publication number: 20030130340Abstract: The present invention relates to novel benzothiophene derivatives represnted by the following formula (I) or salts thereof, inhibitors of steroid 17&agr;-hydroxylase and/or C17-20 lyase, and pharmaceutical compositions containing the benzothiophene derivative or the salt.Type: ApplicationFiled: November 18, 2002Publication date: July 10, 2003Applicant: Daiichi Pharmaceutical Co. Ltd.Inventors: Shin?apos;ichi Shimada, Shin Nomoto, Masayuki Okue, Ken?apos;ichi Kimura, Junji Nakamura, Yoshikazu Ikeda, Takeko Takada
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Patent number: 5959107Abstract: New isoquinoline derivatives and pharmaceutically acceptable acid addition salts represented by the following general formula (I) ##STR1## wherein Ar is an aromatic ring which may be substituted, and n shows 0, 1 or 2, have an inhibitory activity against apoptotic neuronal cell death. These compounds are useful for agents of prevention and treatment of neuronal neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosis, cerebral ischemic injury such as stroke, and peripheral neuropathy in diabetes mellitus.Type: GrantFiled: May 28, 1998Date of Patent: September 28, 1999Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Susumu Ishiguro, Shinichi Shimada, Motohide Seya, Masayuki Okue, Yuzo Yagi, Nobuo Ogane, Yasunari Saitou
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Patent number: 5563137Abstract: Particular hexahydropyrano [3,2-b] [1,4] benzothiazine derivatives represented by the following general formula (I) or pharmaceutically acceptable acid-addition salts thereof. ##STR1## The compounds can facilitate the metabolic turnover of inositol phospholipids at a hippocampus playing an important part in memory, and improve cerebral function leading the memory. The compounds can be utilized as agents for activating brain metabolism and improving cerebral function.Type: GrantFiled: March 8, 1995Date of Patent: October 8, 1996Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Susumu Ishiguro, Shinichi Shimada, Motohide Seya, Yuzo Yagi, Naomi Kito, Noboru Kawaguchi, Masamichi Nakakoshi, Kunio Tomitsuka, Shin Nomoto, Masayuki Okue, Nobuo Ogane, Yasunari Saito