Patents by Inventor Masayuki Shibasaki

Masayuki Shibasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient
    Patent number: 8835474
    Abstract: (R)-2-(2-aminothiazol-4-yl)-4?-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for overactive bladder.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: September 16, 2014
    Assignee: Astellas Pharma Inc.
    Inventors: Toshiyuki Takasu, Shuichi Sato, Masashi Ukai, Tatsuya Maruyama, Masayuki Shibasaki
  • Histidine derivatives as superior renin inhibitors
    Patent number: 4904660
    Abstract: Novel compounds of the following formula (I) and their salts: A compound of the formula (I) ##STR1## These compounds are expected to be useful for renin inhibitors. Thus, the compounds are useful medical agents, in particular, anti-hypertensive agents.
    Type: Grant
    Filed: February 25, 1988
    Date of Patent: February 27, 1990
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kohji Nakano, Takashi Fujikura, Ryuichiro Hara, Masato Ichihara, Yukiko Fukunaga, Masayuki Shibasaki
  • Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient
    Patent number: RE44872
    Abstract: (R)-2-(2-aminothiazol-4-yl)-4?-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for ovaractive bladder.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: April 29, 2014
    Assignee: Astellas Pharma Inc.
    Inventors: Toshiyuki Takasu, Shuichi Sato, Masashi Ukai, Tatsuya Maruyama, Masayuki Shibasaki