Abstract: An object of the present invention is to develop a device and a method by which cargo handling is automatically performed to eliminate overlaps among articles. When loaded with a plurality of articles M, a cargo handling device eliminates overlaps among the articles M. The cargo handling device has an article placement surface on which the articles M are placed. The cargo handling device performs a cargo handling operation that turns and/or rotates the articles M on the article placement surface to eliminate the overlaps among the articles M.

Abstract: An object of the present invention is to develop a device and a method by which cargo handling is automatically performed to eliminate overlaps among articles. When loaded with a plurality of articles M, a cargo handling device eliminates overlaps among the articles M. The cargo handling device has an article placement surface on which the articles M are placed. The cargo handling device performs a cargo handling operation that turns and/or rotates the articles M on the article placement surface to eliminate the overlaps among the articles M.

Abstract: A developing device includes a first developer transport path, called as first path hereinafter; a first transport screw that transports a developer in the first path; a first conveyance roller that is thicker than a shaft of the first transport screw, attracts by magnetic force the developer at a downstream end portion of a second developer transport path arranged next to the first path, and conveys the developer to an upper portion located upstream of the first path; a first scraping wall that scrapes and sends the attracted developer; and a first guide columnar body that is adjacent to the first conveyance roller, has a peripheral surface continuous to the first conveyance roller, receives, using the peripheral surface, and guides the sent developer to an upstream end portion of the first path, and has a length that the guided developer is not attracted by the magnetic force.

Abstract: A developing device includes a first developer transport path, called as first path hereinafter; a first transport screw that transports a developer in the first path; a first conveyance roller that is thicker than a shaft of the first transport screw, attracts by magnetic force the developer at a downstream end portion of a second developer transport path arranged next to the first path, and conveys the developer to an upper portion located upstream of the first path; a first scraping wall that scrapes and sends the attracted developer; and a first guide columnar body that is adjacent to the first conveyance roller, has a peripheral surface continuous to the first conveyance roller, receives, using the peripheral surface, and guides the sent developer to an upstream end portion of the first path, and has a length that the guided developer is not attracted by the magnetic force.

Abstract: The present invention provides an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress metastasis of a cancer cell that expresses human ADAM28. The antibody of the present invention can be a human antibody.

Abstract: An object of the present invention is to develop a conveying device capable of carrying out an object in multiple directions. The conveying device includes a plurality of conveying cells 1 that move the object, and the plurality of conveying cells 1 are arranged in plane. The conveying cell 1 includes a conveying direction changing unit that changes a conveying direction and a controller. An address is given to the conveying cell 1, and based on a conveying destination of the object carried in the conveying cell 1 and an own address of the conveying cell 1, the controller determines a carrying-out direction of the conveying cell 1 such that the object approaches the conveying destination.

Abstract: The present invention provides an antibody having an activity to specifically bind to human membrane-anchored form ADAM28 at an epitope in a region of the 524th-659th amino acids in the amino acid sequence shown in SEQ ID NO: 2. In addition, the present invention provides a drug delivery vehicle for delivering a drug to a cell or tissue that expresses human membrane-anchored form ADAM28, which contains the antibody.

Abstract: An object of the present invention is to develop a conveying device capable of carrying out an object in multiple directions. The conveying device includes a plurality of conveying cells 1 that move the object, and the plurality of conveying cells 1 are arranged in plane. The conveying cell 1 includes a conveying direction changing unit that changes a conveying direction and a controller. An address is given to the conveying cell 1, and based on a conveying destination of the Object carried in the conveying cell 1 and an own address of the conveying cell 1, the controller determines a carrying-out direction of the conveying cell 1 such that the object approaches the conveying destination.

Abstract: Provided is a developing system including a developing device that includes a replenishing unit that replenishes toner into an accommodating portion of a developer including toner and a carrier, via a replenishing port, a receiving unit that includes a transport member that transports received toner to a discharge port, a connecting member that has an internal space that is formed with an inlet connected with the discharge port and an outlet connected with the replenishing port, and a rotating member that is rotated in the internal space, and includes a blocking surface portion that closes the inlet and the outlet while passing over the inlet and the outlet, and a transport surface portion that receives or discharges the toner while passing over the inlet and the outlet.

Abstract: The present invention provides an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress metastasis of a cancer cell that expresses human ADAM28. The antibody of the present invention can be a human antibody.

Abstract: The present invention provides an antibody having an activity to specifically bind to human membrane-anchored form ADAM28 at an epitope in a region of the 524th-659th amino acids in the amino acid sequence shown in SEQ ID NO: 2. In addition, the present invention provides a drug delivery vehicle for delivering a drug to a cell or tissue that expresses human membrane-anchored form ADAM28, which contains the antibody.

Abstract: Provided is a developing system including a developing device that includes a replenishing unit that replenishes toner into an accommodating portion of a developer including toner and a carrier, via a replenishing port, a receiving unit that includes a transport member that transports received toner to a discharge port, a connecting member that has an internal space that is formed with an inlet connected with the discharge port and an outlet connected with the replenishing port, and a rotating member that is rotated in the internal space, and includes a blocking surface portion that closes the inlet and the outlet while passing over the inlet and the outlet, and a transport surface portion that receives or discharges the toner while passing over the inlet and the outlet.

Abstract: The present invention provides an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress metastasis of a cancer cell that expresses human ADAM28. The antibody of the present invention can be a human antibody.

Abstract: The present invention provides an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress metastasis of a cancer cell that expresses human ADAM28. The antibody of the present invention can be a human antibody.

Abstract: The introduction of the human NeuroD1 gene into human non-endocrine pancreatic epithelial cells (NEPECs) for producing insulin producing cells in vitro is described herein. Cytokeratin19 (CK19) positive NEPECs were transfected with plasmids encoding human NeuroD1 gene under human CK19 promoter. On characterization following the induction it was found that NEPEC+ND strongly expressed NeuroD1 and insulin mRNA. The ratio of NeuroD1 and human insulin positive cells in NEPEC+ND was significantly higher than NEPEC. Human insulin and C-peptide levels in culture media in NEPEC+ND were significantly higher than NEPEC. The findings demonstrate that human NeuroD1 under control of the CK19 promoter induces the differentiation of CK19 positive NEPECs into insulin producing cells.

Abstract: An ultrasound-mediated gene transfer method named Ultrasound Targeted Microbubble Destruction (UTMD) for the delivery of human vascular endothelial growth factor (hVEGF) gene to transplanted islets and the surrounding tissue is described herein. The delivery of hVEGF promotes islet revascularization and survival. The inventors, first transplanted human islets were transplanted into diabetic nude mice liver followed by the induction of non-viral plasmid vectors encoding hVEGF or Green Fluorescent Protein (GFP) gene in the host liver by UTMD. Transplantation without gene delivery was also performed as a control. Blood glucose, serum human insulin, C-peptide levels and the revascularization in graft islets were evaluated. The findings of the method of the present invention indicated that hVEGF gene delivery to host liver using UTMD promoted islet revascularization after islet transplantation and improved the restoration of euglycemia.

Abstract: A power-driven grass mower includes an operation division having a grass cutter; a motor division having an electric motor and a power-source division having a battery, wherein the operation division is provided with a first means for watching if the motor division is locked for some reason or other, and a second means for putting the motor division into the inching operation in response to any signal from the first means indicating that the motor division is in a locking condition.

Abstract: The present invention includes a method of isolating pancreatic islets by density centrifugation wherein the pancreatic islets are loaded in a solution comprising pancreatic islets with the density gradient and the islets are isolated by centrifuging the vessel wherein the pressure on the pancreatic islets is less than 50 Pa and wherein the pancreatic islets are isolated from the gradient, the improvement comprising creating a continuous density gradient in a vessel comprising at least 100 milliliters with a bend tube that reduces convection currents that disrupt the gradient.

Abstract: A power-driven grass mower includes an operation division having a grass cutter; a motor division having an electric motor and a power-source division having a battery, wherein the operation division is provided with a first means for watching if the motor division is locked for some reason or other, and a second means for putting the motor division into the inching operation in response to any signal from the first means indicating that the motor division is in a locking condition.