Patents by Inventor Masayuki Towatari

Masayuki Towatari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for screening candidate compounds for antitumor drug
    Patent number: 8426131
    Abstract: Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: April 23, 2013
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hitoshi Kiyoi, Tomoki Naoe, Masayuki Towatari, Toshio Kitamura
  • Method for screening candidate compounds for antitumor drug
    Publication number: 20110257366
    Abstract: Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
    Type: Application
    Filed: November 12, 2010
    Publication date: October 20, 2011
    Inventors: Hitoshi Kiyoi, Tomoki Naoe, Masayuki Towatari, Toshio Kitamura
  • Method for screening candidate compounds for antitumor drug
    Patent number: 7858333
    Abstract: Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: December 28, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hitoshi Kiyoi, Tomoki Naoe, Masayuki Towatari, Toshio Kitamura
  • Method for screening candidate compounds for antitumor drug
    Publication number: 20070009973
    Abstract: Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
    Type: Application
    Filed: September 15, 2006
    Publication date: January 11, 2007
    Inventors: Hitoshi Kiyoi, Tomoki Naoe, Masayuki Towatari, Toshio Kitamura
  • Method and screening candidate compounds for drug against tumor
    Patent number: 7125659
    Abstract: Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: October 24, 2006
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hitoshi Kiyoi, Tomoki Naoe, Masayuki Towatari, Toshio Kitamura