Abstract: Provided are an aqueous liquid preparation showing improved stability of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide or a salt thereof in the aqueous liquid preparation, a method of stabilizing the compound in an aqueous liquid, and a stabilizer of the compound in an aqueous liquid. An aqueous liquid preparation containing the above-mentioned compound and ethylenediaminetetraacetic acid (EDTA) or a salt thereof or a hydrate thereof; a stabilizing method of the compound in an aqueous liquid, including adding the compound and EDTA or a salt thereof or a hydrate thereof to the aqueous liquid; a stabilizer of the above-mentioned compound in an aqueous liquid, which contains EDTA or a salt thereof or a hydrate thereof; and a stabilizer of the compound in an aqueous liquid, which contains EDTA or a salt thereof or a hydrate thereof, and castor oil in combination.

Abstract: The present invention relates to an emulsion composition containing difluprednate and zinc. The present invention also relates to a method of stabilizing an emulsion composition containing difluprednate, the method includes preparing an emulsion composition comprising difluprednate and zinc. According to the present invention, a difluprednate-containing emulsion composition having excellent preservative efficacy and excellent stability (photostability and heat stability) can be provided.

Abstract: The present invention provides a difluprednate emulsion composition showing immediate effectiveness of preservative efficacy. The immediate effectiveness of preservative efficacy is achieved by adding an antimicrobial metal (excluding zinc). The present invention also provides a method of conferring immediate effectiveness of the preservative efficacy to an emulsion composition comprising difluprednate, the method includes preparing an emulsion composition comprising difluprednate and an antimicrobial metal (excluding zinc).

Abstract: A solid dispersion comprising ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester made amorphous in the presence of a water-soluble cellulosic polymer has improved storage stability. The solid dispersion also has improved solubility for an improved bioavailability.

Abstract: A solid dispersion comprising ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester made amorphous in the presence of a water-soluble cellulosic polymer has improved storage stability. The solid dispersion also has improved solubility for an improved bioavailability.

Abstract: The present invention provides a preparation containing a compound of the formula (I) wherein R1 is an alkyl group having 1 to 4 carbon atoms or an optionally substituted aryl group having 6 to 10 carbon atoms; R2 and R3 are the same or different and each is hydrogen or an alkyl group having 1 to 4 carbon atoms, or R2 and R3 in combination form a ring having 3 to 7 carbon atoms; and R4 is a lower alkyl group optionally substituted by aryl, cycloalkyl or aromatic heterocyclic residue, or a pharmaceutically acceptable salt thereof together with a lipid. The preparation shows improved stability and improved absorption and penetration into tissue.

Abstract: The present invention provides a preparation containing a compound of the formula (I) 1

Abstract: A preservative for emulsion, comprising sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid; an emulsion comprising sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid; an emulsion comprising the preservative; a method for preserving an emulsion comprising adding sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid, at a concentration pharmaceutically acceptable and effective for the preservation of the emulsion; use of sorbic acid or a pharmaceutically acceptable salt thereof for the production of an emulsion or preservative for emulsion; and the use comprising adding, where necessary, sodium edetate and boric acid.

Abstract: A preservative for emulsion, comprising sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid; an emulsion comprising sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid; an emulsion comprising the preservative; a method for preserving an emulsion comprising adding sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid, at a concentration pharmaceutically acceptable and effective for the preservation of the emulsion; use of sorbic acid or a pharmaceutically acceptable salt thereof for the production of an emulsion or preservative for emulsion; and the use comprising adding, where necessary, sodium edetate and boric acid.

Abstract: The present invention relates to a liquid composition comprising difluprednate, oil, water and an emulsifier. The composition of the present invention has superior antiinflammatory action and antiallergic action. The composition of the present invention shows superior transfer to a lesion and uniform drug distribution upon administration, as compared to conventional preparations containing difluprednate, so that it shows sufficient efficacy in a smaller dose. The inventive composition is associated with extremely less uncomfortable feeling and foreign sensation upon administration, as compared to conventional preparations containing difluprednate, and it can be administered easily to local sites of eye, nose, ear and the like.