Patents by Inventor Masha V. Poyurovsky

Masha V. Poyurovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of Rho associated coiled-coil containing protein kinase
    Patent number: 11926596
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2 having the formula I: Also provided are methods of inhibiting ROCK1 and/or ROCK2 useful for the treatment of disease.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: March 12, 2024
    Assignee: Kadmon Corporation, LLC
    Inventors: Eduardas Skucas, Kevin G. Liu, Ji-In Kim, Masha V. Poyurovsky, Rigen Mo, Jingya Zhang
  • Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase
    Publication number: 20230174519
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
    Type: Application
    Filed: February 1, 2023
    Publication date: June 8, 2023
    Applicant: Kadmon Corporation, LLC
    Inventors: Eduardas Skucas, Kevin G. Liu, Ji-In Kim, Masha V. Poyurovsky, Rigen Mo
  • Inhibitors of RHO associated coiled-coil containing protein kinase
    Patent number: 11613531
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: March 28, 2023
    Assignee: Kadmon Corporation, LLC
    Inventors: Eduardas Skucas, Kevin G. Liu, Ji-In Kim, Masha V. Poyurovsky, Rigen Mo
  • Glucose Uptake Inhibitors
    Publication number: 20220363648
    Abstract: This invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUTS3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are useful for treating diseases, including cancer, autoimmune diseases and inflammation, infectious diseases, and metabolic diseases.
    Type: Application
    Filed: June 25, 2019
    Publication date: November 17, 2022
    Inventors: Kevin G. Liu, Kellen L. Olszewski, Ji-in Kim, Masha V. Poyurovsky, Koi Morris, Xuemei Yu, Christopher Lamarque
  • Inhibitors of Rho associated coiled-coil containing protein kinase
    Patent number: 11479533
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: October 25, 2022
    Assignee: Kadmon Corporation, LLC
    Inventors: Eduardas Skucas, Kevin G. Liu, Ji-In Kim, Masha V. Poyurovsky, Rigen Mo, Jingya Zhang
  • Treatment of inflammatory conditions and autoimmune diseases with glucose uptake inhibitors
    Patent number: 11071735
    Abstract: This invention provides methods of treating inflammatory conditions and autoimmune diseases in a mammal, comprising administering to the mammalian subject in need thereof a therapeutically effective amount of a compound, or pro-drug thereof, or pharmaceutically acceptable salt or ester of said compound or pro-drug, wherein the compound is an inhibitor of glucose uptake. In particular aspects, the present invention provides a method of treating inflammatory conditions and autoimmune diseases in a mammal, and preferably a human, in which the glucose uptake inhibitor modulates the glucose transport of GLUT1 and GLUT3.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: July 27, 2021
    Assignee: KADMON CORPORATION, LLC
    Inventors: Ji-In Kim, Kellen L. Olszewski, Anthony M. Barsotti, Masha V. Poyurovsky, Kevin G. Liu, Koi Morris, Xuemei Yu
  • INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE
    Publication number: 20210163421
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
    Type: Application
    Filed: July 23, 2018
    Publication date: June 3, 2021
    Inventors: Eduardas Skucas, Kevin G. Liu, Ji-In Kim, Masha V. Poyurovsky, Rigen Mo, Jingya Zhang
  • RHO KINASE INHIBITORS
    Publication number: 20210147391
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2.
    Type: Application
    Filed: June 26, 2020
    Publication date: May 20, 2021
    Inventors: Masha V. Poyurovsky, Ji-In Kim, Kevin G. Liu, Alexandra Zanin-Zhorov
  • Glucose uptake inhibitors
    Patent number: 10988484
    Abstract: Provided herein are compounds that modulate glucose uptake activity and are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and the known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: wherein the variables have the values disclosed herein.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: April 27, 2021
    Assignee: Kadmon Corporation, LLC
    Inventors: Kellen L. Olszewski, Ji-In Kim, Masha V. Poyurovsky, Kevin G. Liu, Anthony Barsotti, Koi Morris
  • Rho kinase inhibitors
    Patent number: 10696660
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: June 30, 2020
    Assignee: Kadmon Corporation, LLC
    Inventors: Masha V. Poyurovsky, Ji-In Kim, Kevin G. Liu, Alexandra Zanin-Zhorov
  • Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase
    Publication number: 20200199109
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
    Type: Application
    Filed: June 13, 2018
    Publication date: June 25, 2020
    Inventors: Eduardas Skucas, Kevin G. Liu, Ji-In Kim, Masha V. Poyurovsky, Rigen Mo
  • INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE
    Publication number: 20200165206
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
    Type: Application
    Filed: July 23, 2018
    Publication date: May 28, 2020
    Inventors: Eduardas Skucas, Kevin G. Liu, Ji-In Kim, Masha V. Poyurovsky, Rigen Mo, Jingya Zhang
  • TREATMENT OF INFLAMMATORY CONDITIONS AND AUTOIMMUNE DISEASES WITH GLUCOSE UPTAKE INHIBITORS
    Publication number: 20200046702
    Abstract: This invention provides methods of treating inflammatory conditions and autoimmune diseases in a mammal, comprising administering to the mammalian subject in need thereof a therapeutically effective amount of a compound, or pro-drug thereof, or pharmaceutically acceptable salt or ester of said compound or pro-drug, wherein the compound is an inhibitor of glucose uptake. In particular aspects, the present invention provides a method of treating inflammatory conditions and autoimmune diseases in a mammal, and preferably a human, in which the glucose uptake inhibitor modulates the glucose transport of GLUT1 and GLUT3.
    Type: Application
    Filed: April 27, 2018
    Publication date: February 13, 2020
    Inventors: Ji-In Kim, Kellen L. Olszewski, Anthony M. Barsotti, Masha V. Poyurovsky, Kevin G. Liu, Koi Morris, Xuemei Yu
  • GLUCOSE UPTAKE INHIBITORS
    Publication number: 20190315772
    Abstract: Provided hererin are compounds that modulate glucose uptake activityand are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and the known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: wherein the variables have the values disclosed herein.
    Type: Application
    Filed: April 29, 2019
    Publication date: October 17, 2019
    Inventors: Kellen L. Olszewski, Ji-In Kim, Masha V. Poyurovsky, Kevin G. Liu, Anthony Barsotti, Koi Morris
  • RHO KINASE INHIBITORS
    Publication number: 20190308953
    Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2.
    Type: Application
    Filed: January 18, 2019
    Publication date: October 10, 2019
    Inventors: Masha V. Poyurovsky, Ji-In Kim, Kevin G. Liu, Alexandra Zanin-Zhorov
  • Glucose uptake inhibitors
    Patent number: 10273248
    Abstract: Provided herein are compounds that modulate glucose uptake activity and are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: Formula (I) wherein the variables have the values disclosed herein.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: April 30, 2019
    Assignee: Kadmon Corportion, LLC
    Inventors: Kellen L. Olszewski, Ji-In Kim, Masha V. Poyurovsky, Kevin G. Liu, Anthony Barsotti, Koi Morris