Patent number: 9808443
Abstract: Cyclooxygenase inhibitors include compounds of the formula: where R represents phenyl, nitrophenyl, 2-nitrophenyl, 3-nitrophenyl, 4-nitrophenyl, 4-chlorophenyl, 2,4-dichlorophenyl, 3,4-dimethoxyphenyl, 2-methoxyphenyl, 4-hydroxyphenyl, dimethylaminophenyl, 3-methoxyphenyl, 4-ethoxyphenyl, 2,4,5-trimethoxyphenyl, 3,4,5-trimethoxyphenyl, 2,4,6-trimethoxyphenyl, and 2,4-dimethoxyphenyl, 3-hydroxyphenyl, 4-dimethylaminophenyl, or 2,3,4-trimethoxyphenyl.
Type:
Grant
Filed:
November 28, 2016
Date of Patent:
November 7, 2017
Assignee:
KING SAUD UNIVERSITY
Inventors:
Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Mohammad Raish, Mushtaq Ahmad Ansari, Hatem A. Abuelizz
Patent number: 9119856
Abstract: A method of treating cancer using a dihydropyrimidine derivative includes administering to a patient a therapeutically effective amount of a dihydropyrimidine derivative having the following formula: wherein: R2 is S or O and R, R1, R3, and R4 each independently represent hydrogen, optionally substituted straight-chain or branched C1 to C7 alkyl, halogen, optionally substituted haloalkyl, alkoxy or haloalkoxy in which the alkyl is straight-chain or branched C1-C4 alkyl and the halo derivatives are mono, di, tri or poly halosubstituted, the optional substituents including halogen, amino, substituted amino, C1-C4 alkyl, halo (C1-C4) alkyl, alkoxy or haloalkoxy having C1-C4 alkyl group, or R, R1, R3, and R4 each independently represent aryl, substituted aryl, heteroaryl, or substituted heteroaryl, the substituents including halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylamino, aryl, heteroaryl, aryloxy, haloaryloxy, arylthio, or arylamino; or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
March 23, 2015
Date of Patent:
September 1, 2015
Assignees:
KING SAUD UNIVERSITY, KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER
Inventors:
Abdullah Omar Al-Dhfyan, Mashooq Ahmad Bhat