Abstract: A sound focusing mechanism for generating a focused source of sound, which can be used to identify the transmission loss of an object or identify areas of acoustic or thermal leakage is disclosed. The sound focusing mechanism includes a housing having at least one wall formed from a material having high sound insulating properties. A sound generating device for generating a sound is located with a central cavity within the housing. An actuator assembly is operatively connected to the sound generating device for selectively operating the sound generating device for selectively operating the sound generating device. The wall is configured to limit the transmission of the sound there through such that a focused beam or pulse sound is emitted from the mechanism through the opening.

Abstract: Stem-cell derived human neuronal models that mimic human Alzheimer's disease, including hereditary and sporadic Alzheimer's disease, comprising neural stem cells derived from human induced pluripotent stem cells. Also provided are purified human neurons developed from the neural stem cells that carry genomes from the Alzheimer's disease patients. The human neuronal models are neuronal models for hereditary and sporadic Alzheimer's disease, and are suitable for measurement of key behaviors of the Alzheimer's disease, providing further diagnostic tools for the development of sporadic Alzheimer's disease, and assisting in drug testing for the therapeutic treatment of Alzheimer's disease.

Abstract: A sound focusing mechanism for generating a focused source of sound, which can be used to identify the transmission loss of an object or identify areas of acoustic or thermal leakage is disclosed. The sound focusing mechanism includes a housing having at least one wall formed from a material having high sound insulating properties. A sound generating device for generating a sound is located with a central cavity within the housing. An actuator assembly is operatively connected to the sound generating device for selectively operating the sound generating device for selectively operating the sound generating device. The wall is configured to limit the transmission of the sound there through such that a focused beam or pulse sound is emitted from the mechanism through the opening.

Abstract: A sound focusing mechanism for generating a focused source of sound, which can be used to identify the transmission loss of an object or identify areas of acoustic leakage is disclosed. The sound focusing mechanism includes a housing having at least one wall formed from a material having high sound insulating properties. A sound generating device for generating a sound is located within a central cavity within the housing. An actuator assembly is operatively connected to the sound generating device for selectively operating the sound generating device. The wall is configured to limit the transmission of the sound there through such that a focused beam or pulse sound is emitted from the mechanism through the opening.

Abstract: A sound focusing mechanism for generating a focused source of sound, which can be used to identify the transmission loss of an object or identify areas of acoustic leakage is disclosed. The sound focusing mechanism includes a housing having at least one wall formed from a material having high sound insulating properties. A sound generating device for generating a sound is located within a central cavity within the housing. An actuator assembly is operatively connected to the sound generating device for selectively operating the sound generating device. The wall is configured to limit the transmission of the sound there through such that a focused beam or pulse sound is emitted from the mechanism through the opening.