Patents by Inventor Massimiliano Tomasulo

Massimiliano Tomasulo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240301131
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Application
    Filed: May 14, 2024
    Publication date: September 12, 2024
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • Publication number: 20240270971
    Abstract: The present disclosure provides UV-absorbing polymer dyes and methods for detecting an analyte in a sample by using a binding partner conjugated to a UV-absorbing polymer dye. Compositions comprising UV-absorbing polymer dyes, UV-absorbing tandem dyes, or quenched UV polymer dyes are provided.
    Type: Application
    Filed: May 3, 2022
    Publication date: August 15, 2024
    Inventors: Arunkumar Easwaran, Massimiliano Tomasulo, Sergei Gulnik, Boi Hoa San
  • Patent number: 12018117
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Grant
    Filed: January 6, 2023
    Date of Patent: June 25, 2024
    Assignee: Beckman Coulter, Inc.
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • Publication number: 20240125773
    Abstract: The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.
    Type: Application
    Filed: February 4, 2022
    Publication date: April 18, 2024
    Inventors: Frederic MONSONIS, Boi Hoa SAN, Arunkumar EASWARAN, Massimiliano TOMASULO, Sergei GULNIK, Rajesh VENKATESH, Shiva Ranjini SRINIVASAN
  • Publication number: 20230399565
    Abstract: The present disclosure provides fused dihydrophenanthrene (DHP) monomers and fluorescent fused DHP polymers, water-soluble fluorescent polymers and copolymers, water-soluble fluorescent polymer complexes, and their use in methods for detecting an analyte in a sample.
    Type: Application
    Filed: June 9, 2023
    Publication date: December 14, 2023
    Inventors: Massimiliano Tomasulo, Mukesh Mudgal, Arunkumar Easwaran, Sergei Gulnik
  • Publication number: 20230192943
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Application
    Filed: January 6, 2023
    Publication date: June 22, 2023
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • Patent number: 11584825
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: February 21, 2023
    Assignee: Beckman Coulter, Inc.
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • Patent number: 11453654
    Abstract: The present invention relates to photochromic indeno fused phenanthrenopyran compounds represented by the following Formula (I). With some embodiments, the photochromic compounds represented by Formula (I) include at least one lengthening group (e.g., R6 and/or R7 each independently being a lengthening group) and the compounds of the present invention are photochromicdichroic compounds. The present invention also relates to photochromic compositions and photochromic articles, such as photochromic ophthalmic articles that include one or more photochromic compounds represented by Formula (I).
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: September 27, 2022
    Assignee: Transitions Optical, Ltd.
    Inventors: Anil Kumar, Darrin R. Dabideen, Shengwen Yuan, Massimiliano Tomasulo
  • Publication number: 20200190253
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Application
    Filed: December 11, 2019
    Publication date: June 18, 2020
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • Publication number: 20200048216
    Abstract: The present invention relates to photochromic indeno fused phenanthrenopyran compounds represented by the following Formula (I). With some embodiments, the photochromic compounds represented by Formula (I) include at least one lengthening group (e.g., R6 and/or R7 each independently being a lengthening group) and the compounds of the present invention are photochromicdichroic compounds. The present invention also relates to photochromic compositions and photochromic articles, such as photochromic ophthalmic articles that include one or more photochromic compounds represented by Formula (I).
    Type: Application
    Filed: May 10, 2017
    Publication date: February 13, 2020
    Inventors: Anil Kumar, Darrin R. Dabideen, Shengwen Yuan, Massimiliano Tomasulo
  • Patent number: 10501477
    Abstract: The present invention relates to photochromic compounds, such as thienochromene compounds represented by the following Formulas (1a) and/or (1b). The present invention also relates to photochromic compositions and articles containing one or more such photochromic thienochromene compounds.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: December 10, 2019
    Assignee: Transitions Optical, Inc.
    Inventors: Jun Deng, Brian R. Stepp, Eric Spitler, Wenjing Xiao, Massimiliano Tomasulo, Robert W. Walters
  • Patent number: 10423061
    Abstract: A multilayer photochromic article can include a photochromic substrate, which may include a first photochromic layer defining a surface of the substrate, and a second photochromic layer positioned between the surface of the photochromic substrate and a source of actinic radiation, and in which the photochromic substrate and the second photochromic layer are selected such that the fade half-life of the photochromic substrate or the half-life of the first photochromic layer defining the surface of the substrate are greater than the fade half-life of the second photochromic layer.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: September 24, 2019
    Assignee: Transitions Optical, Inc.
    Inventors: Massimiliano Tomasulo, Cory Brown, Elizabeth Ann Zezinka
  • Publication number: 20180210330
    Abstract: A multilayer photochromic article can include a photochromic substrate, which may include a first photochromic layer defining a surface of the substrate, and a second photochromic layer positioned between the surface of the photochromic substrate and a source of actinic radiation, and in which the photochromic substrate and the second photochromic layer are selected such that the fade half-life of the photochromic substrate or the half-life of the first photochromic layer defining the surface of the substrate are greater than the fade half-life of the second photochromic layer.
    Type: Application
    Filed: September 3, 2015
    Publication date: July 26, 2018
    Inventors: Massimiliano Tomasulo, Cory Brown, Elizabeth Ann Zezinka
  • Patent number: 9630902
    Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: April 25, 2017
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar
  • Publication number: 20160060205
    Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.
    Type: Application
    Filed: November 10, 2015
    Publication date: March 3, 2016
    Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar
  • Patent number: 9206151
    Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: December 8, 2015
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar
  • Patent number: 9051332
    Abstract: The present invention relates to photochromic indeno-fused ring pyran compounds represented by the following Formula (I-A): The present invention also relates to photochromic dichroic compounds, such as represented by Formula (I-A), in which (i) Z2 is a group N—R13 in which R13 is a group L, and (ii) optionally at least one R1 independently for each n is selected from a group L, in which the group L independently in each case is a lengthening group that provides the photochromic compound with dichroic properties, in accordance with some embodiments. The present invention also relates to photochromic articles, such as photochromic ophthalmic articles, that include one or more photochromic compounds according to the present invention, such as represented by Formula (I-A).
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: June 9, 2015
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Massimiliano Tomasulo, Anil Kumar
  • Publication number: 20150141663
    Abstract: The present invention relates to intermediate compounds represented by the following Formula (I-A), The intermediate compounds of the present invention, such as represented by Formula (I-A), can be used to prepare photochromic compounds, such as photochromic fused ring indenopyran compounds, including but not limited to photochromic fused ring indeno-naphtho-pyran compounds.
    Type: Application
    Filed: November 20, 2013
    Publication date: May 21, 2015
    Applicant: Transitions Optical, Inc.
    Inventors: Meng He, Massimiliano Tomasulo, Anil Kumar
  • Publication number: 20150141661
    Abstract: The present invention relates to photochromic indeno-fused ring pyran compounds represented by the following Formula (I-A): The present invention also relates to photochromic dichroic compounds, such as represented by Formula (I-A), in which (i) Z2 is a group N—R13 in which R13 is a group L, and (ii) optionally at least one R1 independently for each n is selected from a group L, in which the group L independently in each case is a lengthening group that provides the photochromic compound with dichroic properties, in accordance with some embodiments. The present invention also relates to photochromic articles, such as photochromic ophthalmic articles, that include one or more photochromic compounds according to the present invention, such as represented by Formula (I-A).
    Type: Application
    Filed: November 20, 2013
    Publication date: May 21, 2015
    Applicant: Transitions Optical, Inc.
    Inventors: Meng He, Massimiliano Tomasulo, Anil Kumar
  • Publication number: 20150141662
    Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.
    Type: Application
    Filed: November 20, 2013
    Publication date: May 21, 2015
    Applicant: Transitions Optical, Inc.
    Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar