Patents by Inventor Massimo Amicosante

Massimo Amicosante has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM
    Publication number: 20220128558
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Application
    Filed: January 14, 2022
    Publication date: April 28, 2022
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • Use of amino acid sequences from or corresponding nucleic acids for diagnosis and prevention of tubercular infection, diagnostic kit and vaccine therefrom
    Patent number: 11275086
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: March 15, 2022
    Assignee: Cellestis Limited
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM
    Publication number: 20200386755
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Application
    Filed: August 21, 2020
    Publication date: December 10, 2020
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • Use of amino acid sequences from or corresponding nucleic acids for diagnosis and prevention of tubercular infection, diagnostic kit and vaccine therefrom
    Patent number: 10788491
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 29, 2020
    Assignee: Cellestis Limited
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM
    Publication number: 20190383812
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Application
    Filed: August 30, 2019
    Publication date: December 19, 2019
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • Use of amino acid sequences from or corresponding nucleic acids for diagnosis and prevention of tubercular infection, diagnostic kit and vaccine therefrom
    Patent number: 10408833
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: September 10, 2019
    Assignee: CELLESTIS LIMITED
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • proteins
    Patent number: 10295538
    Abstract: The present invention relates to Mycobacterium tuberculosis (M tuberculosis) proteins and immunologically active fragments (peptides or mimotope peptides) thereof. In particular, the invention relates to a group of M. tuberculosis proteins and peptides thereof that are both highly antigenic and characteristic of clinical strains of M. tuberculosis. Accordingly, the further relates to the use of these M. tuberculosis proteins or peptides in diagnosing, treating or preventing M. tuberculosis complex infection.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: May 21, 2019
    Assignee: Oxford Immunotec Limited
    Inventors: Massimo Amicosante, Ian Durrant, Scott Tasker
  • USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM
    Publication number: 20180224450
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Application
    Filed: October 25, 2017
    Publication date: August 9, 2018
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • Use of amino acid sequences from or corresponding nucleic acids for diagnosis and prevention of tubercular infection, diagnostic kit and vaccine therefrom
    Patent number: 9829490
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: November 28, 2017
    Assignee: Cellestis Limited
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • MYCOBACTERIUM TUBERCULOSIS PROTEINS
    Publication number: 20170234871
    Abstract: The present invention relates to Mycobacterium tuberculosis (M tuberculosis) proteins and immunologically active fragments (peptides or mimotope peptides) thereof. In particular, the invention relates to a group of M. tuberculosis proteins and peptides thereof that are both highly antigenic and characteristic of clinical strains of M. tuberculosis. Accordingly, the further relates to the use of these M. tuberculosis proteins or peptides in diagnosing, treating or preventing M. tuberculosis complex infection.
    Type: Application
    Filed: August 14, 2015
    Publication date: August 17, 2017
    Inventors: Massimo Amicosante, Ian Durrant, Scott Tasker
  • USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM
    Publication number: 20150309023
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Application
    Filed: July 13, 2015
    Publication date: October 29, 2015
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • Use of amino acid sequences from mycobacterium tuberculosis or corresponding nucleic acids for diagnosis and prevention of tubercular infection, diagnostic kit and vaccine therefrom
    Patent number: 9110061
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: August 18, 2015
    Assignee: Cellestis Limited
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM
    Publication number: 20130252260
    Abstract: The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
    Type: Application
    Filed: July 25, 2011
    Publication date: September 26, 2013
    Inventors: Francesca Mariani, Massimo Amicosante, Vittorio Colizzi, Cesare Saltini
  • Immune diagnostic assay to diagnose and monitor tuberculosis infection
    Patent number: 7785607
    Abstract: The present invention relates to a method of diagnosing and monitoring various distinct presentations of tuberculosis: active tuberculosis disease, latent tuberculosis infection and recent tuberculosis infection. The rapid immune assay is based on the evaluation of the frequency of Interferon (IFN) gamma-producing antigen-specific T lymphocytes responding to selected peptide sequences from Mycobacterium tuberculosis, selected for their immunogenicity. The invention concerns also immunogenic and vaccine compositions based on these specific peptide sequences.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: August 31, 2010
    Assignee: Istituto Nazionale Delle Malattie Infettive “Lazzaro Spallanzani” IRCCS
    Inventors: Delia Goletti, Donatella Vincenti, Stefania Carrara, Enrico Girardi, Fabrizio Poccia, Rita Casetti, Massimo Amicosante
  • Immune diagnostic assay to diagnose and monitor tuberculosis infection
    Publication number: 20070196878
    Abstract: The present invention relates to a method of diagnosing and monitoring various distinct presentations of tuberculosis: active tuberculosis disease, latent tuberculosis infection and recent tuberculosis infection. The rapid immune assay is based on the evaluation of the frequency of Interferon (IFN) gamma-producing antigen-specific T lymphocytes responding to selected peptide sequences from Mycobacterium tuberculosis, selected for their immunogenicity. The invention concerns also immunogenic and vaccine compositions based on these specific peptide sequences.
    Type: Application
    Filed: February 18, 2005
    Publication date: August 23, 2007
    Applicant: Istituto Nazionale Delle Malattie Infettive "Lazzaro Spallanzani"
    Inventors: Delia Goletti, Donatella Vincenti, Stefania Carrara, Enrico Girardi, Frabrizio Poccia, Rita Casetti, Massimo Amicosante
  • Method and diagnostic tests based on flow cytometric analysis of antigen-specific t lymphocytes
    Publication number: 20070178533
    Abstract: The present invention provides a method for the immuno-diagnosis of diseases with different aetiology (infectious diseases, tumors etc) by measurement of the T cell response J, B and NK lymphocytes) induced by a set of diseasespecific antigens. The method is based on the quantitative determination of antigenspecific T lymphocytes (referred as Ag-Sp), stimulated by using a newly devised pathology-specific antigen or epitope compositions which represent further embodiments of the invention. After stimulation, the selective measurement of the Ag-Sp T lymphocytes is performed by: A) monoclonal antibodies recognizing membrane structures of T lymphocytes and of their sub-populations; B) monoclonal antibodies binding to cytokines accumulating at intracellular level after the stimulation with the antigen; or C) mixtures of A) and B).
    Type: Application
    Filed: August 5, 2004
    Publication date: August 2, 2007
    Inventors: Fabrizio Poccia, Christiana Gioia, Chiara Agrati, Carla Montesano, Massimo Amicosante, Rita Casetti, Gianpiero D'Offizi, Douglas Horejsh, Federico Martini, Maria Capobianchi, Leopoldo Pucillo, Raffaele Perrone Donnorso, Giuseppe Ippolito