Patents by Inventor Massimo Ferrari

Massimo Ferrari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10973868
    Abstract: The present disclosure relates to a composition comprising a carnosine-magnesium complex. The composition is designed to be applied to the skin and causes an increase in carnosine levels in the body. The topical 5 composition comprising a carnosine-magnesium complex has the effect of improving an athlete's physical performance and may be effective for the treatment of a variety of medical conditions. Also disclosed is a method for preparing the carnosine-magnesium complex.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: April 13, 2021
    Inventors: Chad Macias, Tim Sharpe, Massimo Ferrari
  • Patent number: 10844047
    Abstract: The invention relates to a process for preparation of the compound 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole 5, an intermediate for the synthesis of bazedoxifene and bazedoxifene acetate.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: November 24, 2020
    Assignee: ERREGIERRE S.p.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Stefano Vezzosi, Paolo Belotti
  • Publication number: 20190389842
    Abstract: The invention relates to a process for preparation of the compound 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole 5, an intermediate for the synthesis of bazedoxifene and bazedoxifene acetate.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 26, 2019
    Applicant: ERREGIERRE S.p.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Stefano Vezzosi, Paolo Belotti
  • Publication number: 20190216880
    Abstract: The present disclosure relates to a composition comprising a carnosine-magnesium complex. The composition is designed to be applied to the skin and causes an increase in carnosine levels in the body. The topical 5 composition comprising a carnosine-magnesium complex has the effect of improving an athlete's physical performance and may be effective for the treatment of a variety of medical conditions. Also disclosed is a method for preparing the carnosine-magnesium complex.
    Type: Application
    Filed: February 17, 2017
    Publication date: July 18, 2019
    Inventors: Chad MACIAS, Tim SHARPE, Massimo FERRARI
  • Patent number: 10005071
    Abstract: New sulfide metal catalysts are described, containing Ni, Mo and W, an element Z selected from Si, Al and mixtures thereof, and possibly an organic residue, obtained by sulfidation of mixed oxide precursors, also new, characterized in that they comprise an amorphous phase and a wolframite iso structural crystalline phase, the crystallinity degree of said mixed oxides being higher than 0 and lower than 100%, preferably higher than 0 and lower than 70%. The catalysts of the invention are useful as hydrotreatment catalysts, and in particular as hydrodesulfurization, hydrodenitrogenation and/or hydrodearomatization catalysts.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: June 26, 2018
    Assignee: ENI S.P.A.
    Inventors: Angela Carati, Maria Federica Gagliardi, Marco Massimo Ferrari, Stefano Zanardi, Marcello Marella, Michele Tomaselli
  • Patent number: 9802906
    Abstract: Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N?-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III) wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 31, 2017
    Assignee: ERREGIERRE S.P.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • Publication number: 20170291880
    Abstract: Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N?-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III) wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 12, 2017
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • Publication number: 20170136446
    Abstract: New sulfide metal catalysts are described, containing Ni, Mo and W, an element Z selected from Si, Al and mixtures thereof, and possibly an organic residue, obtained by sulfidation of mixed oxide precursors, also new, characterized in that they comprise an amorphous phase and a wolframite iso structural crystalline phase, the crystallinity degree of said mixed oxides being higher than 0 and lower than 100%, preferably higher than 0 and lower than 70%. The catalysts of the invention are useful as hydrotreatment catalysts, and in particular as hydrodesulfurization, hydrodenitrogenation and/or hydrodearomatization catalysts.
    Type: Application
    Filed: November 21, 2016
    Publication date: May 18, 2017
    Inventors: Angela Carati, Maria Federica Gagliardi, Marco Massimo Ferrari, Stefano Zanardi, Marcello Marella, Michele Tomaselli
  • Publication number: 20170079264
    Abstract: The invention relates to an aqueous composition useful for producing antimicrobic polymer films, comprising at least an anionic silver complex, one or more cationic organic components with microbicidal activity, a solvent and a polymeric component. Said antimicrobic films can be obtained by depositing the aqueous composition of the invention on the surface to be treated, possibly followed by a thermosetting or photocuring treatment. The antimicrobic polymer films can be produced on surfaces of containers made of plastic, glass, ceramic or metallic material, thereby ensuring a barrier effect which protects the treated surface from invasions of external microbial agents borne by the air or hands of workers who use such containers.
    Type: Application
    Filed: May 27, 2014
    Publication date: March 23, 2017
    Inventors: Massimo FERRARI, Carlo Alberto BIGNOZZI, Giuliana DI LALLO, Valeria DISSETTE
  • Patent number: 9522394
    Abstract: New sulfide metal catalysts are described, containing Ni, Mo and W, an element Z selected from Si, Al and mixtures thereof, and possibly an organic residue, obtained by sulfidation of mixed oxide precursors, also new, characterized in that they comprise an amorphous phase and a wolframite isostructural crystalline phase, the crystallinity degree of said mixed oxides being higher than 0 and lower than 100%, preferably higher than 0 and lower than 70%. The catalysts of the invention are useful as hydrotreatment catalysts, and in particular as hydrodesulfurization, hydrodenitrogenation and/or hydrodearomatization catalysts.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: December 20, 2016
    Assignee: ENI S.P.A.
    Inventors: Angela Carati, Maria Frederica Gagliardi, Marco Massimo Ferrari, Stefano Zanardi, Marcello Marella, Michele Tomaselli
  • Publication number: 20160235704
    Abstract: The present invention generally relates to Titanium dioxide derivatives of formula TiO2-[L]-Ag+, functionalized with silver cations by a bifunctional mercapto alkylsilane ligand. The present derivatives are useful e.g. as antimicrobic, antiseptic and/or antiviral agent, in particular in the form of pharmaceutical compositions for topical use.
    Type: Application
    Filed: September 24, 2013
    Publication date: August 18, 2016
    Applicant: PAVIA FARMACEUTICI S.R.L.
    Inventors: Massimo FERRARI, Carlo Alberto BIGNOZZI, Valeria DISSETTE, Giuliana DI LALLO
  • Publication number: 20160130234
    Abstract: The present invention generally relates to silver complexes of formula (I) and (II), having high stability and showing antimicrobial activity. The invention also relies on compositions containing said photochemically stable silver complexes of formula (I) and (II), optionally admixed with at least another antimicrobial agent, thus enhancing their antimicrobic activity.
    Type: Application
    Filed: June 6, 2013
    Publication date: May 12, 2016
    Inventor: Massimo FERRARI
  • Publication number: 20160122367
    Abstract: The present invention relates to a dioxide silicon or titanium derivative of formula (I): (MO2)?(Am+)y, as active ingredient for the preparation of a composition having antibacterial properties useful, e.g. for topical administration. The dioxide derivatives of the present invention comprises anionic silica (SiO2)n? or anionic titanium dioxide particles (TiO2)n?, adsorbed with at least one cationic pharmaceutical active moiety (Am+), which may include, for instance, known antibacterial agents such as chlorexidine and the like. Furthermore, the invention relates to a composition for topical use, which may form an efficacious barrier against external microbes, substantially avoiding any infection on the affected skin.
    Type: Application
    Filed: June 6, 2013
    Publication date: May 5, 2016
    Inventor: Massimo FERRARI
  • Patent number: 9206220
    Abstract: The present invention describes a process for the synthesis of ursodeoxycholic acid wherein the purification of the crude ursodeoxycholic acid (containing approximately 13-15% of chenodeoxycholic acid impurity) takes place first passing through a salification with imidazole and a subsequent purification via “methyl ester”, which allows a finished product with an extremely low content of known “cheno and “litho” impurities to be obtained. The present invention also describes the recovery steps of cholic acid and 3?-hydroxy-7-ketocholanic acid from the mother liquors of process intermediates.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: December 8, 2015
    Assignee: Erregierre S.p.A.
    Inventors: Massimo Ferrari, Fabrizio Zinetti
  • Publication number: 20150291651
    Abstract: The present invention describes a process for the synthesis of ursodeoxycholic acid wherein the purification of the crude ursodeoxycholic acid (containing approximately 13-15% of chenodeoxycholic acid impurity) takes place first passing through a salification with imidazole and a subsequent purification via “methyl ester”, which allows a finished product with an extremely low content of known “cheno and “litho” impurities to be obtained. The present invention also describes the recovery steps of cholic acid and 3?-hydroxy-7-ketocholanic acid from the mother liquors of process intermediates.
    Type: Application
    Filed: July 30, 2013
    Publication date: October 15, 2015
    Inventors: Massimo Ferrari, Fabrizio Zinetti
  • Publication number: 20140323291
    Abstract: New sulfide metal catalysts are described, containing Ni, Mo and W, an element Z selected from Si, Al and mixtures thereof, and possibly an organic residue, obtained by sulfidation of mixed oxide precursors, also new, characterized in that they comprise an amorphous phase and a wolframite iso structural crystalline phase, the crystallinity degree of said mixed oxides being higher than 0 and lower than 100%, preferably higher than 0 and lower than 70%. The catalysts of the invention are useful as hydrotreatment catalysts, and in particular as hydrodesulfurization, hydrodenitrogenation and/or hydrodearomatization catalysts.
    Type: Application
    Filed: March 22, 2012
    Publication date: October 30, 2014
    Applicant: Eni S.P.A.
    Inventors: Angela Carati, Maria Frederica Gagliardi, Marco Massimo Ferrari, Stefano Zanardi, Marcello Marella, Michele Tomaselli
  • Patent number: 8802851
    Abstract: The present invention relates, in a first aspect, to a process preparing vilazodone hydrochloride that comprises the reaction of 3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile with 5-piperazin-1-yl-benzofuran-2-carboxylate methyl hydrochloride with the formation of a 1,4-piperazine, with subsequent dehydration, hydrogenation and treatment with ammonia, to obtain vilazodone in free base form that is then converted into the hydrochloride thereof.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: August 12, 2014
    Assignee: Erregierre S.p.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • Publication number: 20140163227
    Abstract: The present invention relates, in a first aspect, to a process preparing vilazodone hydrochloride that comprises the reaction of 3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile with 5-piperazin-1-yl-benzofuran-2-carboxylate methyl hydrochloride with the formation of a 1,4-piperazine, with subsequent dehydration, hydrogenation and treatment with ammonia, to obtain vilazodone in free base form that is then converted into the hydrochloride thereof.
    Type: Application
    Filed: April 2, 2013
    Publication date: June 12, 2014
    Applicant: Erregierre S.p.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • Patent number: 8742172
    Abstract: Crystalline polymorphic forms of a compound of formula N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide are described. The two polymorphic forms, named polymorphic Form A and polymorphic Form B, can be used in the treatment of drug addiction and alcoholism and have very good stability. Methods for preparing the polymorphic forms are also described.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: June 3, 2014
    Assignee: Laboratorio Farmaceutico C.T. S.R.L.
    Inventors: Roberto Cacciaglia, Massimo Ferrari
  • Patent number: RE47078
    Abstract: Crystalline polymorphic forms of a compound of formula N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide are described. The two polymorphic forms, named polymorphic Form A and polymorphic Form B, can be used in the treatment of drug addiction and alcoholism and have very good stability. Methods for preparing the polymorphic forms are also described.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: October 9, 2018
    Assignee: LABORATORIO FARMACEUTICO C.T. S.R.L.
    Inventors: Roberto Cacciaglia, Massimo Ferrari