Abstract: This invention provides methods for inhibiting or reducing thalamic damage in a subject comprising administering to the subject an amount of laquinimod, wherein the subject is a human patient afflicted with a form of multiple sclerosis or presenting a clinically isolated syndrome who has been determined to have thalamic damage at baseline, a subject afflicted with a disease or disorder other than a form of multiple sclerosis or a clinically isolated syndrome, or a subject not afflicted with a form of multiple sclerosis or a presenting clinically isolated syndrome, and laquinimod and laquinimod pharmaceutical compositions for use thereof. This invention also provides methods for inhibiting or reducing tremor or spasticity in a subject afflicted by tremor or spasticity, comprising administering to the subject an amount of laquinimod, and laquinimod and laquinimod pharmaceutical compositions for use thereof.

Abstract: This invention provides methods for inhibiting or reducing thalamic damage in a subject comprising administering to the subject an amount of laquinimod, wherein the subject is a human patient afflicted with a form of multiple sclerosis or presenting a clinically isolated syndrome who has been determined to have thalamic damage at baseline, a subject afflicted with a disease or disorder other than a form of multiple sclerosis or a clinically isolated syndrome, or a subject not afflicted with a form of multiple sclerosis or a presenting clinically isolated syndrome, and laquinimod and laquinimod pharmaceutical compositions for use thereof. This invention also provides methods for inhibiting or reducing tremor or spasticity in a subject afflicted by tremor or spasticity, comprising administering to the subject an amount of laquinimod, and laquinimod and laquinimod pharmaceutical compositions for use thereof.

Abstract: A method of allowing control of a vehicle with at least two-wheels in case of puncture of a tire, each wheel including a rim and a tire associated therewith, includes the steps of: inflating each tire to an operating pressure; admitting a fluid compressed to a first pressure higher than the operating pressure of the tire into at least one tank associated with at least one of the rims; bringing the tire into communication with the tank when the inner pressure of the tire is lower than a predetermined first threshold value; detecting a variation of an inner pressure of the tank; activating a pressure measuring device when the inner pressure variation corresponds to a reduction and is higher than a first predetermined value; measuring the inner pressure of the tank with a predetermined frequency by means of (through) the pressure measuring device; calculating a variation in the inner pressure in a time unit; generating an alarm signal when the calculated inner pressure variation corresponds to a reduction and is

Abstract: A wheel having a controlled and compensated pressure includes a rim associated with a tank adapted to be filled with a fluid to a first pressure; a tyre mounted on the rim and having an inner volume inflated to an operating pressure, the operating pressure being lower than the first pressure; at least one valve adapted to regulate a communication between the tank and the inner volume of the tyre, the valve having at least one elastic element operatively associated with a closure member designed to open and close a port of the valve to bring the tank into communication with the tyre when the pressure of the tyre is lower than the operating pressure, the elastic element having an elastic constant showing a variation of 10% to 40% within a temperature range of about ?50° C. to about 50° C.

Abstract: A method of allowing control of a vehicle with at least two-wheels in case of puncture of a tyre, each wheel including a rim and a tyre associated therewith, includes the steps of: inflating each tyre to an operating pressure; admitting a fluid compressed to a first pressure higher than the operating pressure of the tyre into at least one tank associated with at least one of the rims; bringing the tyre into communication with the tank when the inner pressure of the tyre is lower than a predetermined first threshold value; detecting a variation of an inner pressure of the tank; activating a pressure measuring device when the inner pressure variation corresponds to a reduction and is higher than a first predetermined value; measuring the inner pressure of the tank with a predetermined frequency by means of (through) the pressure measuring device; calculating a variation in the inner pressure in a time unit; generating an alarm signal when the calculated inner pressure variation corresponds to a reduction and is

Abstract: Method of allowing control of a vehicle provided with at least two wheels in case of puncture of a tire, each wheel having a rim and a tire associated therewith, including the steps of inflating each tire to an operating pressure at a reference temperature; admitting a fluid compressed to a first pressure higher than the operating pressure of the tire at the reference temperature into at least one tank associated with at least one of the rims; bringing the tire into communication with the tank when the inner pressure of the tire is lower than the operating pressure by a predetermined first threshold value; measuring the inner pressure of the tire with a predetermined frequency; calculating a variation of the inner pressure in the time unit; generating an alarm signal when the variation of the inner pressure corresponds to a reduction and is higher than a predetermined value; and transmitting the alarm signal to the driver.

Abstract: Method of allowing control of a vehicle provided with at least two wheels in case of puncture of a tire, each wheel having a rim and a tire associated therewith, including the steps of inflating each tire to an operating pressure at a reference temperature; admitting a fluid compressed to a first pressure higher than the operating pressure of the tire at the reference temperature into at least one tank associated with at least one of the rims; bringing the tire into communication with the tank when the inner pressure of the tire is lower than the operating pressure by a predetermined first threshold value; measuring the inner pressure of the tire with a predetermined frequency; calculating a variation of the inner pressure in the time unit; generating an alarm signal when the variation of the inner pressure corresponds to a reduction and is higher than a predetermined value; and transmitting the alarm signal to the driver.

Abstract: A wheel having a controlled and compensated pressure includes a rim associated with a tank adapted to be filled with a fluid to a first pressure; a tyre mounted on the rim and having an inner volume inflated to an operating pressure, the operating pressure being lower than the first pressure; at least one valve adapted to regulate a communication between the tank and the inner volume of the tyre, the valve having at least one elastic element operatively associated with a closure member designed to open and close a port of the valve to bring the tank into communication with the tyre when the pressure of the tyre is lower than the operating pressure, the elastic element having an elastic constant showing a variation of 10% to 40% within a temperature range of about ?50° C. to about 50° C.