Abstract: A safety insert for an extra-corporeal circuit includes a first half-shell and a second half-shell forming a shell defining an inner duct, at least part of the second half-shell being made with a translucent material; a first connector to be connected to the extra-corporeal circuit, and a second connector to be connected to a transducer; and a first hydrophobic semi-permeable membrane having a first area A1 and a second hydrophobic semi-permeable membrane having a second area A2, with the two membranes being arranged in series along the inner duct. In a front view, the extent of an overlapping area A12 of the membranes is between 0% and 50% of the smaller of the two areas A1, A2. An extra-corporeal circuit includes the safety insert.

Abstract: A membrane for a pressure dome is configured to cooperate with a pressure sensor, and includes a resilient circular wall and a circular rim. The resilient circular wall is configured to close one side of the pressure dome so as to define a partition between the inside of the pressure dome and the outside. The circular rim is configured to be housed in a main body of the pressure dome. The membrane is configured such that the resilient circular wall, when there is no difference between the pressures acting respectively on the inner surface and on the outer surface, has an outwardly convex form.

Abstract: The present invention relates to the invention relates to an assembly of a dual lumen tubing as described above and a dual bore connector as described above having a first flow conduit along the first lumen and the first bore, and having a second flow conduit from the second bore, via a circumferential groove and along the second lumen. Such an assembly may be used in connection with an extracorporeal circuit of a haemodialysis machine or an infusion set.

Abstract: The present invention relates to a device designed to promote heat exchange to/from a medical liquid ML. The device comprises an inlet, an outlet and a duct adapted to contain a flow of the medical liquid ML. The duct is enclosed between two walls, has a planar development defining a mean plane ?, and comprises means for promoting turbulence in the flow of the liquid ML. At least one wall of the duct is suitable to allow a heat exchange with the flow of the liquid ML. The means for promoting turbulence comprises a plurality of fins, wherein each fin has a lenticular cross section and defines its own mean plane ?n substantially perpendicular to plane ?. The invention also relates to a disposable cassette for use in a PD/APD treatment, comprising a polymeric structure defining a first part, suitable for pumping and distributing the medical liquid ML, SML, and a second part comprising a device similar to the one described above.

Abstract: The present invention relates to a novel type of tubular insert for connecting an extra-corporeal circuit to a peristaltic pump. This tubular insert comprises a loop formed by a tube portion; the loop comprises a curve which extends around an axis X. The tube which forms the curve has an oval cross-section with a major axis M and a minor axis m perpendicular to each other, where the major axis M is longer than the minor axis m. Finally, in the tubular insert according to the invention, the minor axis m of each cross-section of the tube along the curve is parallel to the axis X The invention further relates to a method for producing the tubular insert and to a peristaltic pump suitable for operating with tubular inserts according both to the invention and to the prior art.

Abstract: A reactor has a reactor unit with a first chamber and a second chamber, with the first chamber being formed by the interior of a housing and the second chamber being formed by the interior of a plurality of hollow fibers arranged in the housing. The hollow fibers are arranged in the housing such that their density in at least one region of the first chamber does not exceed 10 fibers/mm2, based on the cross-sectional area of the first chamber. The reactor unit can include two casting compounds, in which a portion of the hollow fibers are embedded and between which another portion of the hollow fibers extends. The length of at least some or all of the hollow fibers is at least 0.5% greater than the distance of the casting compounds.

Abstract: The invention relates to an insert and a vial for the infusion of a liquid. The vial comprises a hollow body, a grasp portion and a head. The head comprises a delivery opening defining an axis X; a septum for closing the opening; and at least one circumferential push surface next to the head and firmly connected to the grasp portion. The insert is suitable to deliver the liquid and to receive the vial along axis X. The insert comprises a main body with lower ducts, an inner part and a piercing spike. The inner part defines a seat for the vial head, and comprises one slit for engaging the circumferential push surface. The spike is suitable to pierce the vial septum and defines upper ducts. The inner part is able to rotate inside the main body between a fluidly open configuration and a fluidly closed configuration.

Abstract: The present invention refers to a disposable connector 20 suitable for engagement on the substitution port 180 of a hemo filtration machine 18. The connector 20 comprises: a rigid main body 22 defining a duct 220; and a soft element 24 fitted on an end of the main body 22. In the connector 20 according to the invention, the soft element 24 comprises a membrane 240 occluding the duct 220 and performing a valve function; and a seal portion 242 radially expanding outward of the duct 220.

Abstract: The present invention refers to a tubing set suitable for use in co-operation with a medical liquid delivery device. The tubing set comprises: a delivery tube suitable for supplying a medical liquid or blood to a patient; and a vial gate for the connection of vials containing drugs to be delivered into the medical liquid or blood. The vial gate comprises a delivery lumen, suitable for delivering the drug from the vial to the delivery tube; and a vent lumen, suitable for providing a replacement fluid from a location inside the tubing set to the inside of the vial in order to replace the delivered drug. The vial gate according to the invention further comprises at least one one-way valve placed along said vent lumen or said delivery lumen.

Abstract: The present invention relates to a membrane for a pressure dome suitable for cooperation with a pressure sensor. The membrane comprises a resilient circular wall suitable for closing one side of the pressure dome so as to define a partition between the inside of the pressure dome and the outside; and a circular rim suitable for being joined to a main body of the pressure dome. The membrane is characterized in that the resilient circular wall, when there is no difference between the pressures acting respectively on the inner surface and on the outer surface, has an outwardly convex form. The invention also relates to a pressure dome comprising the membrane.

Abstract: The present invention relates to an insert for the infusion of drugs. The insert is suitable for connection to a vial and preferably to a circuit or an infusion line. Moreover the insert comprises a main body, a resilient element and a piercing spike. The piercing spike has an axis X and defines a first channel and a second channel and is movable relative to the main body along the axis X between a first closed position A and a second open position B. Moreover the resilient element presses against the piercing spike so as to keep it in the first closed position A when no external forces are applied.

Abstract: The present invention refers to a tubing set (12) suitable for use in co-operation with a hemodialysis machine (10). The tubing set comprises: an out-tube (14) for supplying the blood from the patient to a filter (16) of the machine; an in-tube (18) for supplying the blood from the filter back to the patient; a drip chamber (20) placed along one of said tubes, adapted to let the blood drip through an air buffer (22); and a vial gate (24) for the connection of vials (26) containing drugs to be delivered into the blood. The vial gate (24) according to the invention comprises a delivery lumen (28), suitable for delivering the drug (30) from the vial to the drip chamber, and a vent lumen (32), suitable for providing air (34) inside the vial in order to replace the delivered drug.

Abstract: For the administering of medicaments, an adapter is provided for connection to a haemodialysis tube set, which makes possible the direct connection of a standard injection vial to the extracorporeal circuit, avoiding the introduction of air into the circuit. The adapter has two conduit pathways. The conduit pathway for the application of medicament contains a gas-blocking element. The second conduit pathway serves for the aeration of the injection vial.

Abstract: The present invention refers to a tubing set (126) suitable for use in co-operation with a machine (100) for carrying out a hemodialysis treatment of a patient's blood. The tubing set comprises: a blood out-tube (102) for supplying the blood from the patient to a filter (106) of said machine; a blood in-tube (114) for supplying the blood from the filter back to the patient; and a substitution tube (116) connected to one of said blood in-tube or blood out-tube suitable for providing a substitution fluid in the patient's blood. According to the invention, the substitution tube comprises an insert (30) for the infusion of drugs. The invention further refers to the insert and to a vial (34) suitable to co-operate with the insert. The invention finally refers to a method for delivering drugs.

Abstract: The invention relates to a circuit for promoting heat exchange to/from a fluid. The circuit comprises two walls sealed to form a duct able to contain a flow of fluid. Each wall comprises, during use, a pattern of corrugations having, at least along sections, a preferential direction. The pattern of corrugations of one wall is positioned to be superimposed at least partially on the one of the other wall so as to form an angle ? between the preferential directions, ? ranging between 70° and 110°. At least one wall is designed to transfer heat to/from the liquid. The invention relates moreover to a device for use with the heat exchange circuit. The device comprises two plates, at least one of which is thermally active and which are shaped to obtain intimate contact with the walls of the circuit, at least in the zones with the corrugations.

Abstract: The present invention relates to a safety insert 20 for an extra-corporeal circuit 19. The safety insert, comprises: a first half-shell 21 and a second half-shell 22 forming a shell 212 defining an inner duct 221, at least part of the second half-shell being made with a translucent or transparent material; a first tubular connector 25 adapted to be connected to a branch pipe 27 from the extra-corporeal circuit, and a second tubular connector 26 defined by the first half-shell and adapted to be connected to a transducer 28; and a first hydrophobic semi-permeable membrane 23 having a first membrane area A1 and a second hydrophobic semi-permeable membrane 24 having a second membrane area A2, said two membranes being arranged in series along said inner duct 221. In a front view, the extent of an overlapping area A12 of said membranes is comprised between 0% and 50% of the smaller of said two membrane areas A1, A2. The inventions further relates to an extra-corporeal circuit 19 comprising the above safety insert.

Abstract: This invention relates to a reactor unit with a first chamber and a second chamber, wherein the first chamber is formed by the interior of a housing and wherein the second chamber is formed by the interior of a plurality of hollow fibers arranged in the housing. The hollow fibers are arranged in the housing such that their density in at least one region of the first chamber does not exceed 10 fibers/mm2, based on the cross-sectional area of the first chamber. In accordance with another aspect of the invention it is provided that in the reactor unit two casting compounds are arranged, in which a portion of the hollow fibers is embedded and between which another portion of the hollow fibers extends, wherein the length of at least some or all hollow fibers is at least 0.5% greater than the distance of the casting compounds.

Abstract: The face or nose mask (1) includes a mask body (2) with an inlet (3). The mask body (2) includes a sealing element with a first chamber (10), and a second chamber (11) which can be connected by connectors (12, 13) to a source of pressurized air.

Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.

Abstract: A device for passive humidification of tracheostomized or intubated patients, comprising an outer body which forms an opening for connection to the patient and is connected to at least one seat of a filtering element which is connected to the outside, the device further comprising, on the outer body, a coupling for connection to at least one oxygen delivery duct which ends proximate to the outer part of the filtering element.