Patents by Inventor Massimo Malago

Massimo Malago has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human liver scaffolds
    Patent number: 10688221
    Abstract: This invention relates to methods for decellularising human liver tissue to produce human hepatic extracellular matrix (ECM) scaffolds, for example for use in therapy or disease modelling. The methods involve mechanically damaging cells in the tissue, for example by freeze thaw, and then subjecting the liver tissue to multiple cycles of osmotic stress, detergent treatment and protease and/or DNAase treatment to produce a decellularised human ECM scaffold.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: June 23, 2020
    Assignee: UCL BUSINESS PLC
    Inventors: Giuseppe Mazza, Massimo Malago, Paolo de Coppi, Massimo Pinzani
  • HUMAN LIVER SCAFFOLDS
    Publication number: 20170112967
    Abstract: This invention relates to methods for decellularising human liver tissue to produce human hepatic extracellular matrix (ECM) scaffolds, for example for use in therapy or disease modelling. The methods involve mechanically damaging cells in the tissue, for example by freeze thaw, and then subjecting the liver tissue to multiple cycles of osmotic stress, detergent treatment and protease and/or DNAase treatment to produce a decellularised human ECM scaffold.
    Type: Application
    Filed: June 2, 2015
    Publication date: April 27, 2017
    Inventors: Giuseppe Mazza, Massimo Malago, Paolo de Coppi, Massimo Pinzani