Abstract: This application is directed to an at least two-way catheter comprising: a first balloon (110, 210) near the end of the catheter; a second balloon (120, 220) at a distance from the first balloon between 0 mm and 6 mm; wherein the first (140, 240) and second tube (150, 250) are coaxial, and the first tube is internal to the second tube, and wherein a drug is present on the surface of the second balloon, wherein the drug is selected from the group consisting of paclitaxel and derivatives thereof, rapamicyn and derivatives thereof, and mixtures thereof.