Patents by Inventor Massoud Motamedi

Massoud Motamedi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11965881
    Abstract: Methods and devices for microfluidic detection of a biological maker in a biospecimen collected from a subject are disclosed. The microfluidic devices include nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker. Also disclosed are particular nanosensors for detecting cytokines, and other proteins based upon supramolecular recognition without chemical modification or enzymatic cleavage.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: April 23, 2024
    Assignees: Kansas State University Research Foundation, Board of Regents of The University of Texas System
    Inventors: Massoud Motamedi, Allan R. Brasier, Stefan H. Bossmann, Christopher T. Culbertson, Deryl Troyer
  • Publication number: 20240125800
    Abstract: Nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker, and methods for rapid diagnosis of lung conditions using specified panels of target biomarkers.
    Type: Application
    Filed: December 29, 2021
    Publication date: April 18, 2024
    Inventors: Stefan H. BOSSMANN, Obdulia COVARRUBIAS-ZAMBRANO, Sumia EHSAN, Kayla ESCHLIMAN, Massoud MOTAMEDI, Raul NERI, Jose COVARRUBIAS
  • Publication number: 20240102995
    Abstract: The present invention relates in general to the field of rapid detection and quantification of tissue/organ injury, and more particularly, to a novel platform for monitoring and quantification of circulating cell-free DNA including within extracellular vesicles, together with extracellular vesicles specific markers, and extracellular vesicles sizes also in combination with PCR-related technologies in biospecimens, and liquid biopsies for the assessment and prediction of severity of tissue/organ injury, monitoring of disease progression as well as the assessment of the response to therapeutic interventions.
    Type: Application
    Filed: September 15, 2023
    Publication date: March 28, 2024
    Inventors: Bartosz Szczesny, Massoud Motamedi, Stefan H. Bossmann
  • Publication number: 20200300849
    Abstract: Methods and devices for microfluidic detection of a biological maker in a biospecimen collected from a subject are disclosed. The microfluidic devices include nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker. Also disclosed are particular nanosensors for detecting cytokines, and other proteins based upon supramolecular recognition without chemical modification or enzymatic cleavage.
    Type: Application
    Filed: March 24, 2017
    Publication date: September 24, 2020
    Inventors: Massoud Motamedi, Allan R. Brasier, Stefan H. Bossmann, Christopher T. Culbertson, Deryl Troyer
  • Patent number: 7863038
    Abstract: A new class of biosensors and methods for making and using same are disclosed. The biosensors are multi-layered membrane composites, where at least one layer is prepared by the layer-by-layer process and at least one layer is responsive to changes is a property of a biological system such as changes in the concentration of an atom, ion, molecule or molecular assembly. Because the biosensors are multi-layered, a single biosensor is capable monitor a number of different properties of a biological system simultaneously. The biosensors are monitored by systems that impinge an excitation waveform on the biosensors and analyze a reflected and/or a transmitted resultant waveform. Additionally, the biosensors can be associated with field activated electronic components so that implantable, self-contained analytical devices can be constructed and monitored by field generators, where data is transmitted to an analyzer after field activation.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: January 4, 2011
    Assignee: Board of Regents, The University of Texas System
    Inventors: Massoud Motamedi, Nicholas A. Kotov, James P. Wicksted, Rinat Esenaliev
  • Publication number: 20070232872
    Abstract: New optical coherence tomography (OCT) techniques are disclosed which are designed to improve OCT glucose concentration measure accuracy and are capable of being performed on a continuous basis. New multi-wavelength optical coherence tomography (OCT) techniques are also disclosed and designed to reduce artifacts do to water. New optical coherence tomography (OCT) techniques are also disclosed for determining local profusion rates, local analyte transport rates and tissue analyte transport rates as a measure of tissue health, disease progression and state and tissue transplantation effectiveness.
    Type: Application
    Filed: March 13, 2007
    Publication date: October 4, 2007
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Donald Prough, Rinat Esenaliev, Massoud Motamedi
  • Patent number: 7074233
    Abstract: Disclosed is a method for delivering energy to a tissue. The method includes providing an apparatus which includes an energy delivery component and an inflatable member disposed around the energy delivery component. At a minimum, the inflatable member is constructed of a flexible inner wall and a flexible outer wall, which, taken together, enclose a cavity therebetween. The inflatable member is expanded such that the inflatable member's outer wall contacts the tissue's surface. Cooling fluid is disposed in the cavity, and energy is delivered to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member's inner wall, through the cooling fluid disposed in the cavity, through the inflatable member's outer wall, and into the tissue.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: July 11, 2006
    Assignees: Board of Regents, The University of Texas System, BioTex, Inc.
    Inventors: Ashok Gowda, Roger J. McNichols, Massoud Motamedi, Pankaj J. Pasricha
  • Publication number: 20050101030
    Abstract: The present invention relates to methods for detecting the presence of TRAIL in cells. The invention also provides methods for identifying dysplastic or cancer cells, methods of identifying substances for use in treating dysplastic or cancer cells, as well as methods for making compounds that are useful in treating dysplastic or cancer cells.
    Type: Application
    Filed: March 14, 2003
    Publication date: May 12, 2005
    Inventors: Pankaj Pasricha, Nikolay Popnikolov, Massoud Motamedi, Zoran Gatalica
  • Patent number: 6755849
    Abstract: Disclosed is a method for delivering energy to a tissue. The method includes providing an apparatus which includes an energy delivery component and an inflatable member disposed around the energy delivery component. At a minimum, the inflatable member is constructed of a flexible inner wall and a flexible outer wall, which, taken together, enclose a cavity therebetween. The inflatable member is expanded such that the inflatable member's outer wall contacts the tissue's surface. Cooling fluid is disposed in the cavity, and energy is delivered to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member's inner wall, through the cooling fluid disposed in the cavity, through the inflatable member's outer wall, and into the tissue.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: June 29, 2004
    Assignees: Board of Regents, The University of Texas System, BioTex, Inc.
    Inventors: Ashok Gowda, Roger J. McNichols, Massoud Motamedi, Pankaj J. Pasricha
  • Patent number: 6751490
    Abstract: An optoacoustic apparatus is disclosed which includes a radiation source of pulsed optical radiation and a probe having a front face to be placed in contact with a tissue site of an animal body. The probe further includes an optical fiber terminating at the surface of the front face of the probe and connected to a pulsed laser. The front face of the probe also has mounted therein or thereon a piezoelectric transducer for detecting an acoustic response to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of hemoglobin concentration and/or hematocrit of blood.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: June 15, 2004
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Rinat Esenaliev, Massoud Motamedi, Donald Prough
  • Patent number: 6736808
    Abstract: A catheter capable of both sensing myocardial electrical activity and delivering ablating energy within myocardial tissue is disclosed. The catheter comprises electrodes on the outer sheath and contains a movable fiber optic cable that can be percutaneously advanced beyond the catheter body and into the myocardium for myocardial heating and coagulation, or modification of tissues responsible for cardiac arrhythmias. The fiber optic tip is designed to diffuse ablating energy radially to ablate a larger volume of tissue than is possible with a bare fiber optic tip. In addition, the tip is treated so that energy is not propagated in a forward direction, thus helping to prevent unwanted perforation of the heart tissue. Also disclosed is a method of cardioprotection from ischemia comprising inducing local hyperthermia in heart tissue.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: May 18, 2004
    Inventors: Massoud Motamedi, David L. Ware
  • Patent number: 6725073
    Abstract: Methods for measuring analyte concentration within a tissue using optical coherence tomography (OCT). Radiation is generated, and a first portion of the radiation is directed to the tissue to generate backscattered radiation. A second portion of the radiation is directed to a reflector to generate reference radiation. The backscattered radiation and the reference radiation is detected to produce an interference signal. The analyte concentration is calculated using the interference signal.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: April 20, 2004
    Assignee: Board of Regents, The University of Texas System
    Inventors: Massoud Motamedi, Rinat O. Esenaliev
  • Publication number: 20040054268
    Abstract: An optoacoustic apparatus is disclosed which includes a radiation source of pulsed radiation and a probe having a front face to be placed in contact with a tissue site of an animal body. The probe further includes an optical fiber terminating at the surface of the front face of the probe and connected at their other end to a pulsed laser. The front face of the probe also has mounted therein or thereon a piezoelectric transducer for detecting an acoustic response to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of hemoglobin concentration and/or hematocrit of blood.
    Type: Application
    Filed: March 1, 2001
    Publication date: March 18, 2004
    Inventors: Rinat Esenaliev, Massoud Motamedi, Donald Prough
  • Publication number: 20040023317
    Abstract: A new class of biosensors and methods for making and using same are disclosed. The biosensors are multi-layered membrane composites, where at least one layer is prepared by the layer-by-layer process and at least one layer is responsive to changes is a property of a biological system such as changes in the concentration of an atom, ion, molecule or molecular assembly. Because the biosensors are multi-layered, a single biosensor is capable monitor a number of different properties of a biological system simultaneously. The biosensors are monitored by systems that impinge an excitation waveform on the biosensors and analyze a reflected and/or a transmitted resultant waveform. Additionally, the biosensors can be associated with field activated electronic components so that implantable, self-contained analytical devices can be constructed and monitored by field generators, where data is transmitted to an analyzer after field activation.
    Type: Application
    Filed: March 31, 2003
    Publication date: February 5, 2004
    Applicants: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, OKLAHOMA STATE UNIVERSITY
    Inventors: Massoud Motamedi, Nicholas A. Kotov, James P. Wicksted, Rinat Esenaliev
  • Patent number: 6507747
    Abstract: An optical imaging probe for providing information representative of morphological arid biochemical properties of a sample is provided. The optical imaging probe includes a spectroscopic imaging probe element and an OCT imaging probe element.
    Type: Grant
    Filed: November 26, 1999
    Date of Patent: January 14, 2003
    Assignees: Board of Regents, The University of Texas System, BioTex, Inc.
    Inventors: Ashok Gowda, Roger McNichols, Massoud Motamedi
  • Patent number: 6498942
    Abstract: An optoacoustic apparatus is disclosed which includes a radiation source of pulsed radiation and a probe having a front face to be placed in close proximity to or in contact with a tissue site of an animal body. The probe further includes a plurality of optical fibers terminating at the surface of the front face of the probe and connected at their other end to a pulsed laser. The front face of the probe also has mounted therein or thereon a transducer for detecting an acoustic response from blood in the tissue site to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of venous blood oxygenation.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: December 24, 2002
    Assignee: The University of Texas System
    Inventors: Rinat O. Esenaliev, Massoud Motamedi, Donald S. Prough, Alexander A. Oraevsky
  • Patent number: 6309352
    Abstract: The present invention is directed to a method/system of for monitoring tissue properties in real time during treatment using optoacoustic imaging system. Optoacoustic monitoring provides a control of the extent of abnormal tissue damage and assures minimal damage to surrounding normal tissues. Such technique can be applied for monitoring and controlling during surgical, therapeutic, and cosmetic procedures performed in various tissues and organs.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: October 30, 2001
    Assignee: Board of Regents, The University of Texas System
    Inventors: Alexander A. Oraevsky, Rinat O. Esenaliev, Massoud Motamedi, Alexander A. Karabutov
  • Patent number: 6143019
    Abstract: A catheter capable of both sensing myocardial electrical activity and delivering ablating energy within myocardial tissue is disclosed. The catheter comprises electrodes on the outer sheath and contains a movable fiber optic cable that can be percutaneously advanced beyond the catheter body and into the myocardium for myocardial heating and coagulation, or modification of tissues responsible for cardiac arrhythmias. The fiber optic tip is designed to diffuse ablating energy radially to ablate a larger volume of tissue than is possible with a bare fiber optic tip. In addition, the tip is treated so that energy is not propagated in a forward direction, thus helping to prevent unwanted perforation of the heart tissue. Also disclosed is a method of cardioprotection from ischemia comprising inducing local hyperthermia in heart tissue.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: November 7, 2000
    Assignee: Board of Regents, The University of Texas System
    Inventors: Massoud Motamedi, David L. Ware
  • Patent number: 5824005
    Abstract: A catheter capable of both sensing myocardial electrical activity and delivering ablating energy within myocardial tissue is disclosed. The catheter comprises electrodes on the outer sheath and contains a movable fiber optic cable that can be percutaneously advanced beyond the catheter body and into the myocardium for myocardial heating and coagulation, or modification of tissues responsible for cardiac arrhythmias. The fiber optic tip is designed to diffuse ablating energy radially to ablate a larger volume of tissue than is possible with a bare fiber optic tip. In addition, the tip is treated so that energy is not propagated in a forward direction, thus helping to prevent unwanted perforation of the heart tissue.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: October 20, 1998
    Assignee: Board of Regents, The University of Texas System
    Inventors: Massoud Motamedi, David L. Ware