Patents by Inventor Masuharu Hirano
Masuharu Hirano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240051971Abstract: Provided is a pharmaceutical composition for enhancing intracellular ATP, including a compound represented by General Formula (I) wherein R1 represents an unsubstituted or substituted phenyl group, R2 represents a cyano group or a nitro group, R3 represents a hydrogen atom or a hydroxyl group, X represents an oxygen atom or —S(O)n—, n represents an integer of 0 to 2, and Y represents an oxygen atom or a sulfur atom, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 8, 2021Publication date: February 15, 2024Inventors: Miki Hiraoka, Ken Okamoto, Masuharu Hirano
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Publication number: 20220323441Abstract: The present invention provides a pharmaceutical composition for treating or preventing gout or hyperuricemia, the pharmaceutical composition including a compound represented by General Formula (I): wherein R1 represents an unsubstituted or substituted phenyl group, R2 represents a cyano group or a nitro group, R3 represents a hydrogen atom or a hydroxyl group, X represents an oxygen atom or —S(O)n—, n represents an integer of 0 to 2, and Y represents an oxygen atom or a sulfur atom, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 4, 2020Publication date: October 13, 2022Inventors: Shiro Kobayashi, Eri Miyayama, Masuharu Hirano, Takashi Ohta
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Publication number: 20220323442Abstract: The present invention provides an enteric-coated preparation, including: a compound represented by General Formula (I) wherein R1 is an unsubstituted phenyl group or a phenyl group substituted with a substituent, the substituent being at least one group selected from the group consisting of an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with a halogen atom, an alkoxy group having 1 to 8 carbon atoms, an alkoxycarbonyl group having 2 to 8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a phenyl group and a phenoxy group, R2 is a cyano group or a nitro group, R3 is a hydrogen atom or a hydroxyl group, X is an oxygen atom or —S(O)n—, n is an integer of 0 to 2, and Y is an oxygen atom or a sulfur atom, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 4, 2020Publication date: October 13, 2022Applicants: Nippon Chemiphar Co., Ltd., Nippon Chemiphar Co., Ltd.Inventors: Masuharu Hirano, Takashi Ohta
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Patent number: 11278528Abstract: There is provided an activator of peroxisome proliferator-activated receptor ? which contains: a compound represented by the following Formula (I); a tautomer or stereoisomer of the compound; or a pharmaceutically acceptable salt or solvate thereof (where, in a case where R1, R2, R3, and R8 do not constitute a ring, in the Formula, R1, R2, R3, R6, R7, and R8 may be the same as or different from each other and represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a hydroxy group, an amino group, a carboxyl group, a mercapto group, an alkylsulfanyl group having 1 to 8 carbon atoms, a nitro group, or a cyano group).Type: GrantFiled: November 14, 2018Date of Patent: March 22, 2022Assignee: Nippon Chemiphar Co., Ltd.Inventors: Masuharu Hirano, Takafumi Muto
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Patent number: 11234984Abstract: The present invention relates to a solid dispersion containing a compound represented by General Formula (I): wherein R1 is an unsubstituted phenyl group or a phenyl group substituted with a substituent; the substituent is an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with a halogen atom, an alkoxy group having 1 to 8 carbon atoms, an alkoxycarbonyl group having 2 to 8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a phenyl group or a phenoxy group; R2 is a cyano group or a nitro group; R3 is a hydroxyl group; X is an oxygen atom or —S(O)n—; n is an integer of 0 to 2; Y is an oxygen atom or a sulfur atom, or a pharmaceutically acceptable salt thereof and a hypromellose derivative.Type: GrantFiled: November 28, 2018Date of Patent: February 1, 2022Assignees: Shizuoka Prefectural University Corporation, Nippon Chemiphar Co., Ltd.Inventors: Shigeru Itai, Shuji Noguchi, Yasunori Iwao, Masuharu Hirano, Takashi Ohta, Tomio Yamakawa
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Publication number: 20200306251Abstract: The present invention relates to a solid dispersion containing a compound represented by General Formula (1): wherein R1 is an unsubstituted phenyl group or a phenyl group substituted with a substituent; the substituent is an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with a halogen atom, an alkoxy group having 1 to 8 carbon atoms, an alkoxycarbonyl group having 2 to 8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a phenyl group or a phenoxy group; R2 is a cyano group or a nitro group; R3 is a hydroxyl group; X is an oxygen atom or —S(O)n—; n is an integer of 0 to 2; Y is an oxygen atom or a sulfur atom, or a pharmaceutically acceptable salt thereof and a hypromellose derivative.Type: ApplicationFiled: November 28, 2018Publication date: October 1, 2020Inventors: Shigeru Itai, Shuji Noguchi, Yasunori Iwao, Masuharu Hirano, Takashi Ohta, Tomio Yamakawa
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Publication number: 20200268719Abstract: There is provided an activator of peroxisome proliferator-activated receptor ? which contains: a compound represented by the following Formula (I); a tautomer or stereoisomer of the compound; or a pharmaceutically acceptable salt or solvate thereof (where, in a case where R1, R2, R3, and R8 do not constitute a ring, in the Formula, R1, R2, R3, R6, R7, and R8 may be the same as or different from each other and represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a hydroxy group, an amino group, a carboxyl group, a mercapto group, an alkylsulfanyl group having 1 to 8 carbon atoms, a nitro group, or a cyano group).Type: ApplicationFiled: November 14, 2018Publication date: August 27, 2020Inventors: Masuharu Hirano, Takafumi Muto
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Patent number: 10173990Abstract: Provided are a compound represented by the following Formula (III), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt or solvate thereof used as a therapeutic agent for gout or hyperuricemia.Type: GrantFiled: December 28, 2015Date of Patent: January 8, 2019Assignees: Nippon Chemiphar Co., Ltd., J-Pharma Co., Ltd., DeThree Res. Lab. Inc.Inventors: Tsuyoshi Endo, Kunio Kobayashi, Hiroto Tanaka, Daisuke Saito, Masuharu Hirano, Hitoshi Endou, Naohiko Anzai
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Patent number: 8314085Abstract: An agent comprising, as an active ingredient, a xanthine oxidase inhibitor such as 2-[3-cyano-4-(4-fluorophenoxy)phenyl]-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-[3-cyano-4-(4-fluorophenoxy)phenyl]thiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-(3-cyano-4-phenoxyphenyl)thiazolo[5,4-d]pyrimidine, TMX-67, and FYX-051, which can be used as an agent for overcoming anti-cancer agent resistance.Type: GrantFiled: June 27, 2011Date of Patent: November 20, 2012Assignee: Nippon Chemiphar Co., Ltd.Inventors: Masuharu Hirano, Tomio Yamakawa, Toshihisa Ishikawa, Hikaru Saito
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Publication number: 20110257201Abstract: An agent comprising, as an active ingredient, a xanthine oxidase inhibitor such as 2-[3-cyano-4-(4-fluorophenoxy)phenyl]-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-[3-cyano-4-(4-fluorophenoxy)phenyl]thiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-(3-cyano-4-phenoxyphenyl)thiazolo[5,4-d]pyrimidine, TMX-67, and FYX-051, which can be used as an agent for overcoming anti-cancer agent resistance.Type: ApplicationFiled: June 27, 2011Publication date: October 20, 2011Applicant: NIPPON CHEMIPHAR CO., LTD.Inventors: Masuharu HIRANO, Tomio YAMAKAWA, Toshihisa ISHIKAWA, Hikaru SAITO
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Publication number: 20100234399Abstract: An agent comprising, as an active ingredient, a xanthine oxidase inhibitor such as 2-[3-cyano-4-(4-fluorophenoxy)phenyl]-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-[3-cyano-4-(4-fluorophenoxy)phenyl]thiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-(3-cyano-4-phenoxyphenyl)thiazolo[5,4-d]pyrimidine, TMX-67, and FYX-051, which can be used as an agent for overcoming anti-cancer agent resistance.Type: ApplicationFiled: June 22, 2007Publication date: September 16, 2010Applicant: NIPPON CHEMIPHAR CO., LTD.Inventors: Masuharu Hirano, Tomio Yamakawa, Toshihisa Ishikawa, Hikaru Saito