Patents by Inventor Masuo Morisaki

Masuo Morisaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1.alpha., 25-dihydroxy-2.beta.-fluorovitamin D.sub.3
    Patent number: 4307025
    Abstract: The invention provides new derivatives of vitamin D.sub.3, specifically, 1.alpha.,25-dihydroxy-2.beta.-fluorocholecalciferol.The compound is characterized by vitamin D-like activity as measured by its ability to stimulate intestinal calcium transport, mobilization of calcium from bone, increase serum inorganic phosphorous and in their antirachitic activity. The compound, could, therefore, find ready application as a substitute for vitamin D in its various known applications and in the treatment of various metabolic bone diseases.
    Type: Grant
    Filed: February 17, 1981
    Date of Patent: December 22, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Nobuo Ikekawa, Yoko Tanaka, Masuo Morisaki, Jun-ichi Oshida
  • 1.alpha.-Hydroxy-2.beta.-fluorocholecalciferol
    Patent number: 4254045
    Abstract: The invention provides new derivatives of vitamin D.sub.3, specifically, 1.alpha.-hydroxy-2.beta.-fluorocholecalciferol.The compound is characterized by vitamin D-like activity as measured by its ability to stimulate intestinal calcium transport, mobilize calcium from bone, increase serum inorganic phosphorous and in their antirachitic acitivity. The compound could, therefore, find ready application as a substitute for vitamin D in its various known applications and in the treatment of various metabolic bone diseases.
    Type: Grant
    Filed: April 21, 1980
    Date of Patent: March 3, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Nobuo Ikekawa, Yoko Tanaka, Masuo Morisaki, Jun-ichi Oshida
  • Novel 1.alpha.,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them
    Patent number: 4022891
    Abstract: Novel 1.alpha., 24-dihydroxycholecalciferol and derivatives thereof which are useful with reduced side-effects for the treatment of abnormal metabolism of calcium and phosphorus caused by liver failure, renal failure, gastrointestinal tract failure and parathyroid failure, and related bone diseases. Preparation of the novel 1.alpha., 24-dihydroxycholecalciferol and their derivatives starts from 1.alpha., 24-dihydroxycholesterol prepared by reacting 1.alpha., 2.alpha.-epoxy-24-keto-cholesta-4,6-dien-3-one with an alkali metal and a proton donor in the presence of liquid ammonia or a liquid amine. Reaction of the 1.alpha., 24-dihydroxycholesterol with an allylic brominating agent, followed by contacting with a dehydrobrominating agent, affords 1.alpha.,3.beta., 24-trihydroxycholesta-5,7-diene derivative, which can then be converted to 1.alpha., 24-dihydroxycholocalciferol by ultraviolet irradiation in a organic solvent, followed by isomerization. Processes are also provided for separating 1.alpha.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: May 10, 1977
    Assignee: Teijin Limited
    Inventors: Toru Takeshita, Yoshinobu Hashimoto, Hiroyuki Kawashima, Sachio Ishimoto, Nobuo Ikekawa, Masuo Morisaki